Results 31 to 40 of about 2,559,828 (152)
Frontiers in Pharmacology, 2021 Aristolactam I (ALI) is an active component derived from some Traditional Chinese medicines (TCMs), and also the important metabolite of aristolochic acid.
Hui-Fang Deng +19 more
doaj +1 more source
Redox Biology, 2016 Early detection is critical in prevention and treatment of kidney disease. However currently clinical laboratory and histopathological tests do not provide region-specific and accurate biomarkers for early detection of kidney disease.
Hua Chen +8 more
doaj +1 more source
CD4+ and CD8+ T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy. [PDF]
Sci Rep, 2018 Experimental aristolochic acid nephropathy is characterized by transient acute proximal tubule necrosis and inflammatory cell infiltrates followed by interstitial fibrosis and tubular atrophy.
Baudoux T +6 more
europepmc +2 more sources
Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis [PDF]
, 2014 Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Schroeder, N +6 more
core +1 more source
Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA [PDF]
, 2010 Ochratoxin A (OTA) is a nephrotoxin and carcinogen that is associated with Balkan endemic nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the liver and kidney DNA of newborns.
Jennings-Gee, Jamie E. +11 more
core +1 more source
Short-term toxicity of aristolochic acid, aristolochic acid-I and aristolochic acid-II in rats [PDF]
, 2010 [[abstract]]We compared the short-term toxicity of toxic components of aristolochic acid in rats. Twenty-four female Wistar rats were divided into 4 groups and treated orally every 3-days with 10 mg/kg each of aristolochic acid, aristolochic acid-I and ...
Yeh, YH (Yeh, Yen-Hung); Lee, YT (Lee, Ya-Ting); Hsieh, HS (Hsieh, Hung-Sheng); Hwang, DF (Hwang, Deng-Fwu)
core +2 more sources
Treatment of Chronic Kidney Diseases with Histone Deacetylase Inhibitors
Frontiers in Physiology, 2015 Histone deacetylases (HDACs) induce deacetylation of both histone and non-histone proteins and play a critical role in the modulation of physiological and pathological gene expression.
Shougang eZhuang, Na eLiu
doaj +1 more source
Molecules, 2019 Aristolochic acid I (AAI) was regarded as the major toxic component of aristolochic acid (AA). In addition to aristolochic acid nephropathy (AAN), liver cancers induced by AAI has aroused increasing attention recently.
Junyi Zhou +8 more
doaj +1 more source
, 2023 Prolonged exposure to aristolochic acids (AAs) through AA-containing herbal medicine or AA-contaminated food is associated with the development of aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), both public health risks to which
Pavlović, Nikola M. +3 more
core +1 more source
Kidney & Blood Pressure Research, 2013 Background: Endemic nephropathy (EN) and associated urothelial cell cancers (UUC) are an environmental form of aristolochic acid nephropathy where the most probable rout of ingestion of aristolochic acid (AA) was made by bread contaminated with AA ...
Sandra Karanović +9 more
doaj +1 more source