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Endemic Nephropathy Around the World [PDF]

open access: yesKidney International Reports, 2017
There have been several global epidemics of chronic kidney disease of unknown etiology (CKDu). Some, such as Itai-Itai disease in Japan and Balkan endemic nephropathy, have been explained, whereas the etiology of others remains unclear. In countries such
Neeraj Dhaun   +2 more
exaly   +4 more sources

Arterial Stiffness in Balkan Endemic Nephropathy, an Environmental Form of Aristolochic Acid Nephropathy [PDF]

open access: yesFrontiers in Cardiovascular Medicine, 2018
Balkan endemic nephropathy (BEN), an environmental form of aristolochic acid nephropathy is characterized with later onset and milder forms of hypertension (HT). Thus, we hypothesized that arterial stiffness progresses slower in BEN patients resulting in
Zivka Dika   +2 more
exaly   +4 more sources

Association of SOD2 (rs4880) and GPX1 (rs1050450) Gene Polymorphisms with Risk of Balkan Endemic Nephropathy and its Related Tumors [PDF]

open access: yesMedicina (Lithuania), 2019
Background and Objectives: Experimental data show that superoxide dismutase 2 (SOD2) is involved in ochratoxin (OTA)-induced nephrotoxicity, whereas clinical data indicate the role of SOD2 rs4880 or glutathione peroxidase 1 (GPX1) rs1050450 polymorphisms
Tatjana Simić   +2 more
exaly   +4 more sources

Molecular Characterization of Microrna Interference and Aristolochic Acid Intoxication Found in Upper Tract Urothelial Carcinoma in Patients with Balkan Endemic Nephropathy: A Systematic Review of the Current Literature [PDF]

open access: yesBalkan Journal of Medical Genetics, 2022
The term “aristolochic acid nephropathy” (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) or by the environmental contaminants in food such as in Balkan ...
Bašić D   +3 more
doaj   +2 more sources

Collecting Duct Carcinoma and Endemic Nephropathy – Case Reports and Literature Review [PDF]

open access: yesActa Clinica Croatica, 2020
Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another renal neoplasm is rare.
Matej Knežević   +7 more
doaj   +2 more sources

Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy [PDF]

open access: yesMedicina, 2019
Background: A previous study indicated that Balkan endemic nephropathy (BEN) patients in the early stage of the disease had significantly higher creatinine clearance (Ccr) than healthy persons.
Ljubica Djukanović   +4 more
doaj   +2 more sources

«Suspects» in Etiology of Endemic Nephropathy: Aristolochic Acid versus Mycotoxins

open access: yesToxins, 2010
Despite many hypotheses that have been challenged, the etiology of endemic nephropathy (EN) is still unknown. At present, the implications of aristolochic acid (AA) and mycotoxins (ochratoxin A—OTA and citrinin—CIT) are under debate.
Maja Šegvić Klaric   +1 more
exaly   +3 more sources

From Bone Pain to Severe Renal Symptoms: The Journey of a Patient With Multiple Myeloma and Brucellosis (Case Report) [PDF]

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT In endemic regions, markedly elevated Brucella serologic titers with a dynamic decline after treatment support true infection even in the presence of monoclonal gammopathy. Concurrent infectious and malignant processes should be considered in patients presenting with severe renal failure and overlapping systemic symptoms to avoid diagnostic ...
Maryam Ghaffari Rahbar   +3 more
wiley   +2 more sources

Expression of Basal Compartment and Superficial Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy, a Worldwide Disease [PDF]

open access: yesBiomedicines
The aim of this study was to determine the association of basal compartment and superficial markers, comprising CK5/6, CD44, CK20, and the pathological characteristics of upper tract urothelial carcinoma (UTUC) associated with Balkan endemic nephropathy (
Ljubinka Jankovic Velickovic   +5 more
doaj   +2 more sources

Unusual Urothelial Tumors and Refractory Uremia Due to Balkan Endemic Nephropathy: A Case Report [PDF]

open access: yesJournal of Investigative Medicine High Impact Case Reports
Balkan endemic nephropathy (BEN) is a rare progressive chronic renal disease found in residents living along the Balkan peninsula. We present a 92-year-old female who complained initially of cardio-respiratory symptoms and was found to have an acute ...
Gevorg Arabyan BS   +5 more
doaj   +2 more sources

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