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Renal fibrosis [PDF]

Korean Journal of Pediatrics, 2010
Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the final manifestation of chronic kidney disease. Renal fibrosis is characterized by an excessive accumulation and deposition of extracellular matrix components. This pathologic result usually originates from both underlying complicated cellular activities such as ...
G, Efstratiadis, M, Divani, E, Katsioulis, G, Vergoulas   +3 more
openaire   +5 more sources

TWIK-related acid-sensitive K+ channel 2 promotes renal fibrosis by inducing cell-cycle arrest

iScience, 2022
Summary: TWIK-related acid-sensitive K+ channel-2 (TASK-2, encoded by Kcnk5) is essential in cell biological processes, by regulating transmembrane K+ balance. In the present study, we aimed to clarify the role of TASK-2 in renal fibrosis and explore the
Jian Zhang, Jing Chen, Yufei Lu, Yan Yang, Weize Chen, Bo Shen, Jiachang Hu, Ping Jia, Sujuan Xu, Yiqin Shi, Yichun Ning, Jialin Wang, Yi Fang, Shuan Zhao, Yang Li, Yan Dai, Xiaoyan Zhang, Meng Xiang, Yang Tian, Zhichao Liu, Nana Song, Xiaoqiang Ding   +21 more
doaj   +1 more source

Natural Products Against Renal Fibrosis via Modulation of SUMOylation

Frontiers in Pharmacology, 2022
Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development ...
Peng Liu, Jing Zhang, Yun Wang, Chen Wang, Xinping Qiu, Dan-Qian Chen   +5 more
doaj   +1 more source

Stem cells in the treatment of renal fibrosis: a review of preclinical and clinical studies of renal fibrosis pathogenesis

Stem Cell Research & Therapy, 2021
Renal fibrosis commonly leads to glomerulosclerosis and renal interstitial fibrosis and the main pathological basis involves tubular atrophy and the abnormal increase and excessive deposition of extracellular matrix (ECM).
Yiping Liu, Yan-Yan Su, Qian Yang, Tianbiao Zhou   +3 more
doaj   +1 more source

Urinary exosomes derived circRNAs as biomarkers for chronic renal fibrosis

Annals of Medicine, 2022
Background Chronic renal disease (CKD) is a common and irreversible loss of renal function. Renal fibrosis reflected the degree of renal dysfunction. However, the current biomarkers only characterize the renal function instead of indicating the fibrosis ...
Yuhan Cao, Yuanhui Shi, Yanlang Yang, Zhangli Wu, Nana Peng, Jie Xiao, Fan Dou, Jingjing Xu, Wenjun Pei, Cong Fu, Pingsheng Chen, Yuwei Wang   +11 more
doaj   +1 more source

Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis [PDF]

, 2015
Extracellular-signal regulated kinase (ERK) activation by MEK plays a key role in many of the cellular processes that underlie progressive kidney fibrosis including cell proliferation, apoptosis and transforming growth factor β1-mediated epithelial to ...
AA Eddy, Arif Khwaja, B Conway, B Hinz, C Stambe, D Bokemeyer, D Bokemeyer, D Feliers, David Long, DY Rhyu, E Diaz-Flores, Faith Hannah Nutter, FY Ma, FY Ma, FY Ma, G Wolf, GA Reif, GM D'Abaco, H Fujita, H Ha, H Tamouza, HJ Anders, J Chen, John L. Haylor, JW Pippin, JY Seo, L Aoudjit, LF Allen, LL Huang, M Peake, M Sabbatini, M Zeisberg, MA Chetram, MH De Borst, N Sakai, P Moreno-Layseca, PM Lorusso, R Ohashi, R Roskoski Jr, S Omori, S Wang, S Wang, SD Oldroyd, SK Jo, SP Davies, T Ishida, T Masaki, T Wada, T Xu, W Bechtel, Y Han   +50 more
core   +10 more sources

Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury

Scientific Reports, 2022
Acute kidney injury (AKI) is common in patients, causes systemic sequelae, and predisposes patients to long-term cardiovascular disease. To date, studies of the effects of AKI on cardiovascular outcomes have only been performed in male mice.
Danielle E. Soranno, Peter Baker, Lara Kirkbride-Romeo, Sara A. Wennersten, Kathy Ding, Brysen Keith, Maria A. Cavasin, Christopher Altmann, Rushita A. Bagchi, Korey R. Haefner, John Montford, Katja M. Gist, Laurent Vergnes, Karen Reue, Zhibin He, Hanan Elajaili, Kayo Okamura, Eva Nozik, Timothy A. McKinsey, Sarah Faubel   +19 more
doaj   +1 more source

Research Progress of Chinese Herbal Medicine Intervention in Renal Interstitial Fibrosis

Frontiers in Pharmacology, 2022
Chronic kidney diseases usually cause renal interstitial fibrosis, the prevention, delay, and treatment of which is a global research hotspot. However, no definite treatment options are available in modern medicine.
Xiao-Yuan Liu, Xu-Bin Zhang, Ya-Feng Zhao, Kai Qu, Xiao-Yong Yu   +4 more
doaj   +1 more source

Revealing Potential Diagnostic Gene Biomarkers Associated with Immune Infiltration in Patients with Renal Fibrosis Based on Machine Learning Analysis

Journal of Immunology Research, 2022
Chronic kidney disease is characterized by the development of renal fibrosis. The basic mechanisms of renal fibrosis have not yet been fully investigated despite significant progress in understanding the etiology of the disease.
Yu-Chao Sun, Zhen-Zhen Qiu, Fu-Li Wen, Jin-Quan Yin, Hao Zhou   +4 more
doaj   +1 more source

Advances in Understanding the Effects of Erythropoietin on Renal Fibrosis

Frontiers in Medicine, 2020
Renal fibrosis is the common manifestation of the pathogenesis of end-stage renal disease that results from different types of renal insult, and is a hallmark of chronic kidney disease (CKD).
Yangyang Zhang, Xiaoyu Zhu, Xiu Huang, Xuejiao Wei, Dan Zhao, Lili Jiang, Xiaoxia Zhao, Yujun Du   +7 more
doaj   +1 more source