Results 31 to 40 of about 136,377 (260)

Autophagy in renal fibrosis: Protection or promotion?

Frontiers in Pharmacology, 2022
Autophagy is a process that degrades endogenous cellular protein aggregates and damaged organelles via the lysosomal pathway to maintain cellular homeostasis and energy production.
Rong Dai, Lei Zhang, Hua Jin, Dong Wang, Meng Cheng, Tian Sang, Chuyi Peng, Yue Li, Yiping Wang   +8 more
doaj   +1 more source

MicroRNAs in renal fibrosis [PDF]

Frontiers in Physiology, 2015
MicroRNAs (miRNAs) are endogenous short non-coding RNAs that regulate most of important cellular processes by inhibiting gene expression through the post-transcriptional repression of their target mRNAs. In kidneys, miRNAs have been associated in renal development, homeostasis, and physiological functions.
Chung, Arthur C.-K., Lan, Hui Y.
openaire   +3 more sources

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source

Klotho and Renal Fibrosis [PDF]

Nephro-Urology Monthly, 2013
Klotho is a newly discovered protein with pleotropic effects and have affected different fields of renal medicine from translational research to clinical nephrology. Here we want to summarize some new scopes in the field of renal fibrosis and Klotho with this hope that in future it could be implemented as a new therapeutic strategy to combat the renal ...
Zununi Vahed, Sepide, Nikasa, Parisa, Ardalan, Mohammadreza   +2 more
openaire   +2 more sources

Foxp3-Positive Regulatory T Cells Contribute to Antifibrotic Effects in Renal Fibrosis via an Interleukin-18 Receptor Signaling Pathway

Frontiers in Medicine, 2020
Renal interstitial fibrosis is a common lesion in the process of various progressive renal diseases. Interleukin (IL)-18 is a proinflammatory cytokine that plays an important role in the induction of Th1 responses and is associated with renal ...
Yasuaki Hirooka, Yuji Nozaki, Kaoru Niki, Asuka Inoue, Masafumi Sugiyama, Koji Kinoshita, Masanori Funauchi, Itaru Matsumura   +7 more
doaj   +1 more source

Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice [PDF]

Endocrinology and Metabolism, 2017
BackgroundRenal tubulointerstitial fibrosis is a common feature of the final stage of nearly all cause types of chronic kidney disease. Although classic peroxisome proliferator-activated receptor γ (PPARγ) agonists have a protective effect on diabetic ...
Kwi-Hyun Bae, Jung Beom Seo, Yun-A Jung, Hye-Young Seo, Sun Hee Kang, Hui-Jeon Jeon, Jae Man Lee, Sungwoo Lee, Jung-Guk Kim, In-Kyu Lee, Gwon-Soo Jung, Keun-Gyu Park   +11 more
doaj   +1 more source

Cell Cycle Dysregulation and Renal Fibrosis

Frontiers in Cell and Developmental Biology, 2021
Precise regulation of cell cycle is essential for tissue homeostasis and development, while cell cycle dysregulation is associated with many human diseases including renal fibrosis, a common process of various chronic kidney diseases progressing to end ...
Yun-Shan Wu, Shan Liang, Dong-Yi Li, Jun-Hao Wen, Ji-Xin Tang, Ji-Xin Tang, Hua-Feng Liu   +6 more
doaj   +1 more source

The role of Krüppel-like factor 4 in renal fibrosis

Frontiers in Physiology, 2015
Chronic kidney disease (CKD) caused by renal fibrosis is an important public health concern. It is therefore necessary to understand the molecular pathogenesis of renal fibrosis in order to develop novel therapeutic strategies.
Ben eKe, Afei eZhang, Xianfeng eWu, Xiangdong eFang   +3 more
doaj   +1 more source

Angiotensin II and Renal Fibrosis [PDF]

Hypertension, 2001
Abstract — — Angiotensin (Ang) II, the main peptide of the renin angiotensin system (RAS), is a renal growth factor, inducing hyperplasia/hypertrophy depending on the cell type. This vasoactive peptide activates mesangial and tubular cells and interstitial fibroblasts, increasing the ...
Mezzano, SA, Ruiz-Ortega, M, Egido, J
openaire   +4 more sources

Metabolic Reprogramming and Renal Fibrosis [PDF]

Frontiers in Medicine, 2021
There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to ...
Xiaoyu Zhu, Lili Jiang, Mengtuan Long, Xuejiao Wei, Yue Hou, Yujun Du   +5 more
openaire   +3 more sources