Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice [PDF]
Endocrinology and Metabolism, 2017 BackgroundRenal tubulointerstitial fibrosis is a common feature of the final stage of nearly all cause types of chronic kidney disease. Although classic peroxisome proliferator-activated receptor γ (PPARγ) agonists have a protective effect on diabetic ...
Kwi-Hyun Bae +11 more
doaj +1 more source
Cell Cycle Dysregulation and Renal Fibrosis
Frontiers in Cell and Developmental Biology, 2021 Precise regulation of cell cycle is essential for tissue homeostasis and development, while cell cycle dysregulation is associated with many human diseases including renal fibrosis, a common process of various chronic kidney diseases progressing to end ...
Yun-Shan Wu +6 more
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The role of Krüppel-like factor 4 in renal fibrosis
Frontiers in Physiology, 2015 Chronic kidney disease (CKD) caused by renal fibrosis is an important public health concern. It is therefore necessary to understand the molecular pathogenesis of renal fibrosis in order to develop novel therapeutic strategies.
Ben eKe +3 more
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Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review [PDF]
The Korean Journal of Internal MedicineChronic kidney disease is estimated to affect approximately 10 to 15% of the Chinese population. Renal fibrosis is characterized by progressive extracellular matrix deposition in the kidney parenchyma with eventual tissue scarring and inevitable ...
Yousuf Abdulkarim Waheed +2 more
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Cell–Matrix Interactions in Renal Fibrosis
Kidney and Dialysis, 2022 Renal fibrosis is a hallmark of end-stage chronic kidney disease. It is characterized by increased accumulation of extracellular matrix (ECM), which disrupts cellular organization and function within the kidney.
Kristin P. Kim +2 more
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Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]
, 2010 Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Sayyed, Sufyan Ali +2 more
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Hepatitis B and C co-Infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults [PDF]
, 2012 Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-positive individuals. Hepatitis C (HCV) co-infection has been associated with increased risk of CKD, but prior studies lack information on potential mechanisms.
Bickel, M +37 more
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Regulation of Renal Fibrosis by Macrophage Polarization
Cellular Physiology and Biochemistry, 2015 Background/Aims: Since renal fibrosis always predisposes end-stage renal disease, elucidation of the molecular mechanisms that underlie the progression of renal fibrosis may substantially improve the understanding and treatment for renal failure ...
Bixia Pan +3 more
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T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease. [PDF]
Adv Sci (Weinh)This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Li Q +11 more
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lncRNA TUG1 regulates hyperuricemia-induced renal fibrosis in a rat model
Acta Biochimica et Biophysica Sinica, 2022 Renal fibrosis is most common among chronic kidney diseases. Molecular studies have shown that long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) participate in renal fibrosis, while the roles of lncRNA taurine upregulated gene 1 (TUG1) and miR-140-3p ...
Zhang Ying +4 more
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