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Cell–Matrix Interactions in Renal Fibrosis
Kidney and Dialysis, 2022 Renal fibrosis is a hallmark of end-stage chronic kidney disease. It is characterized by increased accumulation of extracellular matrix (ECM), which disrupts cellular organization and function within the kidney.
Kristin P. Kim +2 more
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Renal interstitial fibrosis [PDF]
Current Opinion in Nephrology and Hypertension, 2012 Tubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IFTA) as the final common pathway. Furthermore, there are multiple ways to assess IFTA.Cells involved include tubular epithelial cells, fibroblasts, fibrocytes ...
Alton B, Farris, Robert B, Colvin
openaire +2 more sources
Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review [PDF]
The Korean Journal of Internal MedicineChronic kidney disease is estimated to affect approximately 10 to 15% of the Chinese population. Renal fibrosis is characterized by progressive extracellular matrix deposition in the kidney parenchyma with eventual tissue scarring and inevitable ...
Yousuf Abdulkarim Waheed +2 more
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TGFβ1 orchestrates renal fibrosis following Escherichia coli pyelonephritis [PDF]
, 2020 Renal scarring after pyelonephritis is linked to long-term health risks for hypertension and chronic kidney disease. Androgen exposure increases susceptibility to, and severity of, uropathogenic Escherichia coli (UPEC) pyelonephritis and resultant ...
Collins, Christina A +5 more
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Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]
, 2000 The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim +1 more
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Upregulation of Transglutaminase andε(γ-Glutamyl)-Lysine in the Fisher-Lewis Rat Model of Chronic Allograft Nephropathy [PDF]
, 2014 Background. Tissue transglutaminase (TG2), a cross-linking enzyme, modulates deposition of extracellular matrix protein in renal fibrosis. This study aimed to examine TG2 and its cross-link product ε(γ-glutamyl)-lysine in the Fisher-Lewis rat renal ...
Butt, Imran +7 more
core +3 more sources
Regulation of Renal Fibrosis by Macrophage Polarization
Cellular Physiology and Biochemistry, 2015 Background/Aims: Since renal fibrosis always predisposes end-stage renal disease, elucidation of the molecular mechanisms that underlie the progression of renal fibrosis may substantially improve the understanding and treatment for renal failure ...
Bixia Pan +3 more
doaj +1 more source
lncRNA TUG1 regulates hyperuricemia-induced renal fibrosis in a rat model
Acta Biochimica et Biophysica Sinica, 2022 Renal fibrosis is most common among chronic kidney diseases. Molecular studies have shown that long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) participate in renal fibrosis, while the roles of lncRNA taurine upregulated gene 1 (TUG1) and miR-140-3p ...
Zhang Ying +4 more
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Changes in renal WT-1 expression preceding hypertension development [PDF]
, 2016 Background: Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information.
Abud, María Angélica +8 more
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Frontiers in Cell and Developmental Biology, 2021 Renal fibrosis is considered as the final pathway of all types of kidney diseases, which can lead to the progressive loss of kidney functions and eventually renal failure. The mechanisms behind are diversified, in which the mammalian target of rapamycin (
Weiwei Liu +9 more
doaj +1 more source