Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway
Frontiers in Cell and Developmental Biology, 2021 Renal fibrosis is the most common pathological manifestation of a wide variety of chronic kidney disease. Increased extracellular matrix (ECM) secretion and enhanced microenvironment stiffening aggravate the progression of renal fibrosis.
Yuanyuan Fu +12 more
doaj +1 more source
MicroRNAs in fibrosis: opportunities and challenges [PDF]
, 2016 MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22-25 nucleotides in length via partial complementary binding to the 3' untranslated region in target transcripts ...
O'Reilly, Steven, Steven O’Reilly
core +1 more source
The role of the macrophage-to-myofibroblast transition in renal fibrosis
Frontiers in Immunology, 2022 Renal fibrosis causes structural and functional impairment of the kidney, which is a dominant component of chronic kidney disease. Recently, a novel mechanism, macrophage-to-myofibroblast transition (MMT), has been identified as a crucial component in ...
Jia Wei, Zihao Xu, Xiang Yan
doaj +1 more source
Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]
, 2004 Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Anders, Hans-Joachim +3 more
core +1 more source
Research progress on the mechanism of renal interstitial fibrosis in obstructive nephropathy
Heliyon, 2023 Renal fibrosis is a common result for various chronic kidney diseases developing to the end stage. It is a pathological process characterized by the destruction of normal kidney structure and the subsequent replacement with fibrous tissue, which ...
Kangning Wang, Qiuling Liao, Xiang Chen
doaj +1 more source
TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]
, 2010 Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core +1 more source
Renal pericytes: regulators of medullary blood flow [PDF]
, 2012 Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Peppiatt-Wildman, Claire M. +10 more
core +1 more source
Targeted exhaled breath analysis for detection of Pseudomonas aeruginosa in cystic fibrosis patients [PDF]
, 2021 Background Pseudomonas aeruginosa (PA) is an important respiratory pathogen for cystic fibrosis (CF) patients. Routine microbiology surveillance is time-consuming, and is best performed on expectorated sputum. As alternative, volatile organic compounds (
Davies, Jane +16 more
core +1 more source
Frontiers in Medicine, 2020 Renal interstitial fibrosis is a common lesion in the process of various progressive renal diseases. Interleukin (IL)-18 is a proinflammatory cytokine that plays an important role in the induction of Th1 responses and is associated with renal ...
Yasuaki Hirooka +7 more
doaj +1 more source
HMGB-1 - a novel mediator of inflammatory-induced renal epithelial mesenchymal transition [PDF]
, 2010 Background: High mobility group box protein 1 (HMGB-1) is a chromatin binding protein that bends DNA thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has ...
Ryan, Michael P. +11 more
core +1 more source