Results 21 to 30 of about 2,559,828 (152)

Ogg1 regulates TGF‑β–Smad3 signalling and fibrosis progression in chronic kidney disease [PDF]

Communications Biology
Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and a major contributor to progression toward end-stage renal disease. Here, we identify 8-oxoguanine DNA glycosylase 1 (Ogg1), a DNA repair enzyme, as a regulator of kidney fibrosis.
Ying Wang, Yan Liu, Bo Peng, Chan Zou, Guoping Yang, Jiefu Zhu, Hao Zhang, Jing Huang   +7 more
doaj   +2 more sources

Molecular Characterization of Microrna Interference and Aristolochic Acid Intoxication Found in Upper Tract Urothelial Carcinoma in Patients with Balkan Endemic Nephropathy: A Systematic Review of the Current Literature

Balkan Journal of Medical Genetics, 2022
The term “aristolochic acid nephropathy” (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) or by the environmental contaminants in food such as in Balkan ...
Bašić D, Ignjatović I, Janković Veličković Lj, Veljković A   +3 more
doaj   +1 more source

Detection and Removal of Aristolochic Acid in Natural Plants, Pharmaceuticals, and Environmental and Biological Samples: A Review

Molecules, 2023
Aristolochic acids (AAs) are a toxic substance present in certain natural plants. Direct human exposure to these plants containing AAs leads to a severe and irreversible condition known as aristolochic acid nephropathy (AAN).
Changhong Wang, Yunchao Liu, Jintai Han, Wenying Li, Jing Sun, Yinan Wang   +5 more
doaj   +1 more source

Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury

Tomography, 2022
Exposure to aristolochic acid (AA) is of increased concern due to carcinogenic and nephrotoxic effects, and incidence of aristolochic acid nephropathy (AAN) is increasing.
Yingjie Mei, Guixiang Yang, Yihao Guo, Kaixuan Zhao, Shuyu Wu, Zhongbiao Xu, Shan Zhou, Chenggong Yan, Erdmann Seeliger, Thoralf Niendorf, Yikai Xu, Yanqiu Feng   +11 more
doaj   +1 more source

Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity

Molecules, 2020
Twelve compounds, including two new aristolochic acid analogues with a formyloxy moiety (9–10) and 10 known aristolochic acid derivates (1–8 and 11–12), were obtained from the roots of Aristolochiacontorta.
Hong-Jian Ji, Jia-Yuan Li, Shi-Fei Wu, Wen-Yong Wu, Chang-Liang Yao, Shuai Yao, Jian-Qing Zhang, De-An Guo   +7 more
doaj   +1 more source

Rapid Analysis of Aristolochic Acid Analogues in Traditional Chinese Patent Medicine by LC-MS/MS

Journal of Analytical Methods in Chemistry, 2020
Aristolochic acids have been demonstrated to have renal toxicity, cause carcinogenesis, and may cause gene mutations. A series of risk control measurements have been adopted worldwide since 1990s.
Jing Liu, Yang Liu, Yingxue Wu, Zhong Dai, Shuangcheng Ma   +4 more
doaj   +1 more source

Patterns of renal pathology in Chinese patients with systemic sclerosis undergoing renal biopsy at a tertiary medical center

Journal of International Medical Research, 2020
Objective We investigated renal injury characteristics in Chinese patients with systemic sclerosis (SSc) who had undergone renal biopsy. Methods We searched the medical records of patients with SSc who were hospitalized at Peking Union Medical College ...
Xiao-yu Cao, He Liu, Dong Xu, Meng-tao Li, Qian Wang, Li Jiang, Yong Hou, Li-xiu Zhu, Xiao-feng Zeng   +8 more
doaj   +1 more source

Interactions of Human Organic Anion Transporters With Aristolochic Acids

Journal of Pharmacological Sciences, 2010
Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion ...
Ellappan Babu, Michio Takeda, Ritsuo Nishida, Rie Noshiro-Kofuji, Masaaki Yoshida, Shiro Ueda, Toshiyuki Fukutomi, Naohiko Anzai, Hitoshi Endou   +8 more
doaj   +1 more source

Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy [PDF]

, 2012
Chinese herbs nephropathy (CHN) and Balkan endemic nephropathy (BEN) are chronic tubulointerstitial renal diseases associated with urothelial carcinoma.
Marc E. De Broe, De Broe, Marc E.
core   +1 more source

Aristolochic acid causes albuminuria by promoting mitochondrial DNA damage and dysfunction in podocyte. [PDF]

PLoS ONE, 2013
Aristolochic acid nephropathy, initially found in patients intaking of slimming herbs containing aristolochic acid (AA), was previously considered as a progressive renal interstitial fibrosis and urothelial malignancy.
Yang Zhou, Xueqin Bian, Li Fang, Weichun He, Chunsun Dai, Junwei Yang   +5 more
doaj   +1 more source