«Suspects» in Etiology of Endemic Nephropathy: Aristolochic Acid versus Mycotoxins
Toxins, 2010 Despite many hypotheses that have been challenged, the etiology of endemic nephropathy (EN) is still unknown. At present, the implications of aristolochic acid (AA) and mycotoxins (ochratoxin A—OTA and citrinin—CIT) are under debate.
Stjepan Pepeljnjak +1 more
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Aristolochic acid nephropathy - still real danger [PDF]
Journal of Education, Health and Sport, 2022 Arystolocholic acid nephropathy is chronic kidney disease caused by the use of substances of natural origin that contain arystolocholic acid. The effects of their use are arystolochic acid nephropathies, which include "Chinese Herbs" nephropathy.
Rafal Oleszczuk +4 more
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Aristolochic Acid Induced Suicidal Erythrocyte Death
Kidney & Blood Pressure Research, 2014 Background/Aims: Aristolochic Acid, a component of Aristolochia plants, has been shown to cause acute kidney injury, renal aristolochic acid nephropathy, Balkan endemic nephropathy, and urothelial carcinoma.
Abaid Malik +5 more
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Is Aristolochic Acid Really the Cause of the Balkan Endemic Nephropathy? [PDF]
Journal of Controversies in Biomedical Research, 2016 In recent years, aristolochic acid has been promoted vigorously as the causal agent of the Balkan endemic nephropathy because of similarities to some other nephropathies, association with DNA adducts and a perception of human exposure via bread. Critical
Peter George Mantle +2 more
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An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature [PDF]
International Journal of Molecular Sciences, 2017 The term “aristolochic acid nephropathy” (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as part of traditional phytotherapies (formerly known as “Chinese
Anne-Emilie Declèves +2 more
exaly +4 more sources
Advanced ScienceAlthough significant progress in identifying molecular mediators of fibrosis is made, there is still controversy regarding the role and mechanism of autophagy in kidney fibrosis.
Yan Hu +11 more
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PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation [PDF]
eLifeAristolochic acid nephropathy (AAN) is a progressive kidney disease caused by herbal medicines. Proline–serine–threonine phosphatase-interacting protein 2 (PSTPIP2) and neutrophil extracellular traps (NETs) play important roles in kidney injury and ...
Changlin Du +13 more
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Renal Protective Effects of 17β-Estradiol on Mice with Acute Aristolochic Acid Nephropathy [PDF]
Molecules, 2016 Aristolochic acid nephropathy (AAN) is a progressive kidney disease caused by a Chinese herb containing aristolochic acid. Excessive death of renal tubular epithelial cells (RTECs) characterized the acute phase of AAN.
Min Shi, Liang Ma, Li Zhou, Ping Fu
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Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids. [PDF]
J Appl ToxicolABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
de Souza VV +2 more
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Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy [PDF]
Advances in Pharmacological Sciences, 2011 The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli.
Chiao-Shih Tseng +3 more
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