Results 51 to 60 of about 2,559,828 (152)

Mitochondrial Dysfunction in Aristolochic Acid I-Induced Kidney Diseases: What We Know and What We Do Not Know

Applied Sciences
Aristolochic acids, compounds derived from Aristolochiaceae plant species, are associated with significant renal nephrotoxicity and carcinogenicity. Aristolochic acid I (AAI), the most predominant and potent of these compounds, is a primary etiological ...
Alexandra T. Lukinich-Gruia, Crenguta L. Calma, Flavia A. E. Szekely, Iustina-Mirabela Cristea, Maria-Alexandra Pricop, Alina-Georgiana Simina, Valentin L. Ordodi, Nikola M. Pavlović, Calin A. Tatu, Virgil Paunescu   +9 more
doaj   +1 more source

Unambiguous detection of multiple TP53 gene mutations in AAN-associated urothelial cancer in Belgium using laser capture microdissection.

PLoS ONE, 2014
In the Balkan and Taiwan, the relationship between exposure to aristolochic acid and risk of urothelial neoplasms was inferred from the A>T genetic hallmark in TP53 gene from malignant cells.
Selda Aydin, Anne-France Dekairelle, Jérôme Ambroise, Jean-François Durant, Michel Heusterspreute, Yves Guiot, Jean-Pierre Cosyns, Jean-Luc Gala   +7 more
doaj   +1 more source

Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity. [PDF]

PLoS ONE, 2016
Aristolochia manshuriensis Kom (AMK) is a member of the Aristolochiaceae family and is a well-known cause of aristolochic acid (AA) nephropathy. In this study, we investigated the potential of omeprazole (OM) to alleviate AMK-induced nephrotoxicity.
Lianmei Wang, Hongbing Zhang, Chunying Li, Yan Yi, Jing Liu, Yong Zhao, Jingzhuo Tian, Yushi Zhang, Xiaolu Wei, Yue Gao, Aihua Liang   +10 more
doaj   +1 more source

BK virus‐associated urothelial carcinoma—A supra‐regional cohort of kidney transplant recipients

BJUI Compass, Volume 7, Issue 3, March 2026.
Abstract Objectives This study aims to study the clinical features, pathological findings, and outcomes of BK virus‐associated urothelial carcinoma (UC) in kidney transplant recipients (KTRs). Patients and Methods The study was conducted in a retrospective cohort of KTRs with histologically confirmed UC managed at a UK supra‐regional transplant urology
Noah Beetge, Luis Ribeiro, Rhana Zakri, Catherine Horsfield, Jonathon Olsburgh   +4 more
wiley   +1 more source

Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN)

BMC Medical Genetics, 2012
Background Balkan Endemic Nephropathy (BEN) is late-onset kidney disease thought to arise from chronic exposure to aristolochic acid, a phytotoxin that contaminates wheat supplies in rural areas of Eastern Europe.
Wooding Stephen P, Atanasova Srebrena, Gunn Howard C, Staneva Rada, Dimova Invanka, Toncheva Draga   +5 more
doaj   +1 more source

Disease Burden and Disparities of Care for Kidney Health in the Asian Pacific Region: Summary Report From the Diversity and Equity Committee of APSN

Nephrology, Volume 31, Issue 3, March 2026.
ABSTRACT Aim The Diversity and Equity Committee (DEC) of the Asian Pacific Society of Nephrology (APSN) conducted a regional review to characterise disparities in kidney disease burden, healthcare access and nephrology service delivery across the Asia‐Pacific (AP) region.
I‐Wen Wu, Hayne Cho Park, Jia Liang Kwek, Lorraine Kwan, Saruultuvshin Adiya, Shilpanjali Jesudason, Bryan Chong Men Leong, Khin Phyu Pyar, Warangkana Pichaiwong, Kornchanok Vareesangthip, Pringgodigdo Nugroho, Andrew David Henderson, Xiaoqiang Ding, Dhiraj Narayan Manandhar, Jihyun Yang, Motoko Yanagita   +15 more
wiley   +1 more source

Collecting Duct Carcinoma and Endemic Nephropathy – Case Reports and Literature Review

Acta Clinica Croatica, 2020
Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another renal neoplasm is rare.
Matej Knežević, Karla Tomić, Damir Dittrich, Ivana Vuković Lela, Boris Ružić, Borislav Spajić, Krešimir Karlović, Goran Štimac   +7 more
doaj   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, Volume 26, Issue 2-3, Page 33-80, February 2026.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Using an affinity‐based probe, this study reveals that aristolochic acid directly binds to HIGD1A with high affinity in the kidney. This binding disrupts the HIGD1A‐TFAM interaction, which in turn triggers TFAM degradation, cytosolic mitochondrial DNA release, and the activation of inflammatory pathways. Abstract Exposure to aristolochic acids (AA) via
Yin Gong, Shanshan Zhang, Anying Wei, Xiang Ji, Xiaodan Chong, Jinfeng Cen, Xuan Zhao, Zimeng Luo, Zhipeng Pei, Guanchao Mao, Xinkang Zhang, Mingxue Sun, Zhiguo Sun, Zifei Yin, Zhengrong Zou, Wen‐Qi Meng   +15 more
wiley   +1 more source

MicroRNA‐382 Is Involved in Acute Kidney Injury via Regulating STAT1 Signaling

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Acute kidney injury (AKI), characterized by inflammation and oxidative stress, is a life‐threatening clinical presentation. We previously demonstrated the role of miR‐382 in the progression of chronic kidney disease (CKD). However, the role of miR‐382 in AKI is unknown.
Xiaoyan Wang, Guo Cheng, Ting Ren, Zhouping Zou, Xinni Zhang, Shuan Zhao, Siyu Bao, Yingxiang Li, Ping Jia, Yi Fang, Xiaoqiang Ding, Poorani Gurumallesh   +11 more
wiley   +1 more source