Results 71 to 80 of about 2,559,828 (152)

GREM1 deficiency induced bone marrow adipose niche promotes B‐cell acute lymphoblastic leukemia disease progression

International Journal of Cancer, Volume 157, Issue 3, Page 559-572, 1 August 2025.
What's new? Too often, children treated for B‐cell acute lymphocytic leukemia (B‐ALL) experience relapse. Here, the authors investigate the role of dyslipidemia in leukemia progression. Higher adipogenicity in bone marrow mesenchymal stem cells, and increased triglyceride accumulation, are associated with higher risk of death.
Lili Song, Rui Zhang, Liya Pan, Qiang Mi, Yi Yang, Xiang Wang, Yani Ma, Shuhong Shen, Benshang Li, Yanxin Li, Li Hong   +10 more
wiley   +1 more source

Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid [PDF]

, 2012
Endemic (Balkan) nephropathy is a chronic tubulointerstitial disease frequently accompanied by urothelial cell carcinomas of the upper urinary tract.
Dickman, Kathleen G., Stipančić, Želimir, Želimir Stipančić, Branko Brdar, Slade, Neda, Jelaković, Bojan, Sandra Karanović, Neda Slade, Arthur P. Grollman, Kathleen G. Dickman, Miller, Frederick, Karanović, Sandra, Brdar, Branko, Jovan Nikolić, Tomić, Karla, Karen L. Edwards, Dittrich, Damir, Frederick Miller, Damir Dittrich, Turesky, Robert J., Robert J. Turesky, Grollman, Arthur P., Nikolić, Jovan, Ivana Vuković-Lela, Karla Tomić, Bojan Jelaković, Vuković-Lela, Ivana, Edwards, Karen L.   +27 more
core   +1 more source

A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This review highlights the molecular mechanism by which lycopene imparts its anticancerous role, focusing on clinical and animal trials to validate its effectiveness. The antioxidant profile of lycopene promotes anticancerous properties that reduce cancer prevalence by activating cell signaling pathways and gene expression (involved in cancer cell ...
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Usman Khalid, Hassan Raza, Muhammad Imran, Muzzamal Hussain, Waleed Al Abdulmonem, Suliman A. Alsagaby, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Muhammad Asif Khan, Tadesse Fenta Yehuala, Samy Selim, Ehab M. Mostafa   +13 more
wiley   +1 more source

Short-term toxicity of aristolochic acid, aristolochic acid-I and aristolochic acid-II in rats.

, 2012
[[abstract]]We compared the short-term toxicity of toxic components of aristolochic acid in rats. Twenty-four female Wistar rats were divided into 4 groups and treated orally every 3-days with 10 mg/kg each of aristolochic acid, aristolochic acid-I and ...
謝宥諒;Hsieh, You-Liang
core  

Aristolochic acid nephropathy revisited: a place for innate and adaptive immunity? [PDF]

, 2010
Pozdzik A A, Berton A, Schmeiser H H, Missoum W, Decaestecker C, Salmon I J, Vanherweghem J-L & Nortier J L(2010) Histopathology56, 449–463Aristolochic acid nephropathy revisited: a place for innate and adaptive immunity?Aims:  The histological features ...
Schmeiser, Heinz H, Nortier, Joëlle, Salmon, Isabelle, Pozdzik, Agnieszka, Berton, Alix, Missoum, Wassim, Vanherweghem, Jean-Louis, Decaestecker, Christine   +7 more
core   +1 more source

Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis

Advanced Science, Volume 12, Issue 3, January 20, 2025.
Myeloid‐derived growth factor (MYDGF) is decreased in proximal tubules from patients with chronic kidney disease (CKD) and correlates with key factors related to kidney fibrosis and estimated glomerular filtration rate. MYDGF deficiency in tubules exacerbates kidney injury in CKD mice. MYDGF overexpression upregulates isocitrate dehydrogenase 2 (IDH2),
Xiaohan Liu, Yang Zhang, Youzhao Wang, Yujie Yang, Zhe Qiao, Ping Zhan, Huiying Jin, Qianqian Xu, Wei Tang, Yu Sun, Yan Zhang, Fan Yi, Min Liu   +12 more
wiley   +1 more source

miR-192 induces G2/M growth arrest in aristolochic acid nephropathy

, 2014
Aristolochic acid nephropathy is characterized by rapidly progressive tubulointerstitial nephritis culminating in end-stage renal failure and urothelial malignancy.
Davies, Luke C., Taylor, Philip R., Beltrami, Cristina, Carrington, Christopher P., Fraser, Donald J., Bowen, Timothy, Akiyama, Hideo, Cumbes, Bevan, Phillips, Aled O., Jenkins, Robert H.   +9 more
core   +1 more source

Study on metabolism of plant carcinogen aristolochic acid I

, 2022
Aristolochic acids (AA) are natural compounds present in plant species of Aristolochiaceae. These plant alkaloids exhibit nephrotoxic effects and are human carcinogens.
Dedíková, Alena
core  

ELEVEN ARISTOLOCHIC ACID-DERIVATIVES FROM ARISTOLOCHIA-CINNABARINA

, 1994
Three new compounds, aristolochic acid IIIa-6-O-beta-D-glucoside, cepharanone-A N-beta-D-glucoside and 2-hydroxy-8-methyloxycepharanone-A, were isolated together with eight known compounds from methanolic extracts of fresh roots of Aristolochia ...
SAKAGAMI, Y, LI, H, MARUMO, S, CHEN, XM
core  

Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up.

, 2008
BACKGROUND: Aristolochic acids are nephrotoxins and predispose to upper-tract urothelial carcinoma. The risk of bladder urothelial carcinoma after kidney transplantation and its relationship to upper-tract urothelial carcinoma is not well defined.
Zlotta, Alexandre, Nortier, Joëlle, Abramowicz, Daniel, Salmon, Isabelle, Wissing, Karl Martin, Roumeguere, Thierry, Rorive, Sandrine, Muniz Martinez, Marie Carmen, Vanherweghem, Jean-Louis, Lemy, Anne, Decaestecker, Christine   +10 more
core   +1 more source