Results 81 to 90 of about 2,559,828 (152)

Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid i in renal tissue from patients with aristolochic acid nephropathy

, 2014
Aristolochic acid (AA) causes aristolochic acid nephropathy (AAN), first described in women in Belgium accidently prescribed Aristolochia fangchi in a slimming treatment, and also Balkan endemic nephropathy (BEN), through probable dietary contamination ...
Nortier, Joëlle, Schmeiser, Heinz H, da Costa, Gonçalo Gamboa, Pozdzik, Agnieszka, Schmeiser, Heinz H.H., Cassuto-Viguier, Elisabeth, Stiborova, Marie, Sennesael, Jacques, Phillips, David D.H., Singh, Rajinder, Phillips, David H, Ambrosetti, Damien, Arlt, Volker V.M., Rorive, Sandrine, Gamboa Da Costa, Gonçalo, Arlt, Volker M; id_orcid, Nortier, Jöelle L   +16 more
core   +1 more source

Reduced kidney levels of lysophosphatidic acids in rats after chronic administration of aristolochic acid: Its possible protective role in renal fibrosis

Toxicology Reports, 2015
Aristolochic acid (AA) is considered to be a causative agent for progressive interstitial renal fibrosis, leading to AA nephropathy. Lysophosphatidic acid (LPA) is a mediator in the onset of renal fibrosis.
Toshihiko Tsutsumi, Syougo Yamakawa, Akira Ishihara, Aimi Yamamoto, Tamotsu Tanaka, Akira Tokumura   +5 more
doaj   +1 more source

TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours

, 2009
The proposal has been put forward that the primary cause of Balkan endemic nephropathy (BEN) is exposure to food crops contaminated with seeds of Aristolochia spp, which contain high levels of aristolochic acids (AA).
Phillips, David H, Nedelko, Tatiana, Hollstein, Monica, Arlt, Volker M; id_orcid   +3 more
core   +1 more source

Renal tubular epithelial cell related partial epithelial-mesenchymal transition in AAⅠ induced renal fibrosis via Wnt7b/β-catenin signaling

Frontiers in Pharmacology
IntroductionThis study investigates the pathological progressions in kidneys affected by aristolochic acid nephropathy (AAN) and explores the molecular mechanisms underlying the fibrotic process, specifically focusing on the Wnt7b/β-catenin signaling ...
Yi-Fan Wang, Yi-Fan Wang, Dan Zheng, Ying Zhang, Ying Zhang, Xiao-Fen Li, Xiao-Fen Li, Ming Xia, Ming Xia, Hai-Ming Tang, Hai-Ming Tang, Chun-Hua Huang, Chun-Hua Huang, Mao-Juan Li, Mao-Juan Li, Di-Dong Lou, Di-Dong Lou   +16 more
doaj   +1 more source

Aristolochic Acids: Newly Identified Exposure Pathways of this Class of Environmental and Food-Borne Contaminants and its Potential Link to Chronic Kidney Diseases

Toxics, 2019
Aristolochic acids (AAs) are nitrophenanthrene carboxylic acids naturally produced by Aristolochia plants. These plants were widely used to prepare herbal remedies until AAs were observed to be highly nephrotoxic and carcinogenic to humans.
Chi-Kong Chan, Yushuo Liu, Nikola M. Pavlović, Wan Chan   +3 more
doaj   +1 more source

Aristolochic acid and the etiology of endemic (Balkan) nephropathy [PDF]

, 2007
Endemic (Balkan) nephropathy (EN), a devastating renal disease affecting men and women living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, is characterized by its insidious onset, invariable progression to chronic renal failure and a
Goodenough, Angela K., Jakovina, Krunoslav, Turesky, Robert J., Rosenquist, Thomas, Slade, Neda, Grollman, Arthur P., Jelaković, Bojan, Shibutani, Shinya, Brdar, Branko, Moll, Ute, Medverec, Zvonimir, Moriya, Masaaki, Rieger, Robert, Vukelić, Mato, Fernandes, Andrea, Suzuki, Naomi, Miller, Fredrick, Wu, Lin   +17 more
core   +1 more source

Comparative 1H NMR Metabolomic Urinalysis of People Diagnosed with Balkan Endemic Nephropathy, and Healthy Subjects, in Romania and Bulgaria: A Pilot Study

Toxins, 2011
1H NMR spectroscopy of urine has been applied to exploring metabolomic differences between people diagnosed with Balkan endemic nephropathy (BEN), and treated by haemodialysis, and those without overt renal disease in Romania and Bulgaria.
Draga Toncheva, Diana Tatu, Calin Tatu, Andrew Nicholls, Mirela Modalca, Peter Mantle   +5 more
doaj   +1 more source

Nephropathy and tumour development caused by plant alkaloids aristolochic acid

, 2010
Aristolochic acids (AA) are alkaloids contained in plant species of the family Aristolochiaceae. These plants are used since antiquity in traditional medicine to treatment of many varied diseases.
Bárta, František
core  

Molecular mechanism of carcinogenicity of aristolochic acid [PDF]

, 2013
Aristolochic acids (AA) are carcinogenic and nephrotoxic alkaloids from Aristolochia species. Aristolochic acid I (AAI), the major component of AA, causes the development of Aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN).
Levová, Kateřina
core  

Mechanism of chronic aristolochic acid nephropathy: role of Smad3

, 2010
Aristolochic acid nephropathy (AAN) has become a worldwide disease and is the most severe complication related to the use of traditional Chinese medicine. However, the pathogenic mechanisms of AAN remain unclear and therapies are limited.
Lai, KN, Huang, XR, Liu, F, Chung, ACK, Lan, HY, Fu, P, Zhou, L   +6 more
core   +1 more source