Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids [PDF]
Advanced ScienceExposure to aristolochic acids (AA) via the ingestion of AA‐containing medicine or food is a significant risk factor for severe nephropathy. Despite decades of research, the direct molecular targets underlying AA toxicity remain elusive. In this study, a
Yin Gong +15 more
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Review on NMR spectroscopic data and recent analytical methods of aristolochic acids and derivatives in Aristolochia herbs [PDF]
Natural Products and BioprospectingAristolochic acids (AAs) are an important group of secondary metabolites in the genus Aristolochia. The presence of aristolochic acids infers the potency of many Aristolochia herbs used for ages in traditional medicine of China, Europe, Central America ...
Phan Minh Giang +6 more
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Protective Effect of Nebivolol against Oxidative Stress Induced by Aristolochic Acids in Endothelial Cells [PDF]
Toxins, 2022 Aristolochic acids (AAs) are powerful nephrotoxins that cause severe tubulointerstitial fibrosis. The biopsy-proven peritubular capillary rarefaction may worsen the progression of renal lesions via tissue hypoxia.
Marie-Hélène Antoine +6 more
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Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms [PDF]
Frontiers in Pharmacology, 2019 Aristolochic acids (AAs) are a group of toxins commonly present in the plants of genus Aristolochia and Asarum, which are spread all over the world.
Jiayin Han +4 more
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Overview of aristolochic acid nephropathy: an update [PDF]
Kidney Research and Clinical Practice, 2023 Aristolochic acid nephropathy (AAN) is a rapidly progressive renal interstitial fibrosis caused by medical or environmental exposure to aristolochic acid (AA).
Qingqing Zhou +4 more
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Temporal Variation of Aristolochia chilensis Aristolochic Acids during Spring [PDF]
Molecules, 2015 In this communication, we report the springtime variation of the composition of aristolochic acids (AAs) in Aristolochia chilensis leaves and stems. The dominant AA in the leaves of all samples, which were collected between October and December, was AA-I
Rocío Santander +3 more
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Aristolochic acid I exposure decreases oocyte quality
Frontiers in Cell and Developmental Biology, 2022 Oocyte quality is a determinant of a successful pregnancy. The final step of oocyte development is oocyte maturation, which is susceptible to environmental exposures.
Weidong Li +11 more
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Aristolochic acids — Induced transcriptomic responses in rat renal proximal tubule cells in vitro [PDF]
Genomics Data, 2015 Aristolochic acids (AAs) are the active components of herbal drugs derived from Aristolochia species that have been used for medicinal purposes since antiquity.
Katarzyna M. Bloch +2 more
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Aristolochic acid nephropathy [PDF]
BMJ, 2012 A disease that could be prevented through more careful regulation of herbal products More than 20 years ago a Belgian report described nine women with rapidly progressive fibrosing interstitial nephritis who either required dialysis or showed progressive renal impairment.1 All of the women had taken a slimming regimen that included herbs of the ...
Goekmen, M. Refik, Lord, Graham M.
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Biomolecules, 2021 Aristolochic acids are known for nephrotoxicity, and implicated in multiple cancer types such as hepatocellular carcinomas demonstrated by recent studies.
Tingjun Xu +5 more
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