Results 51 to 60 of about 4,033 (193)

Periodontitis and high phosphate intake alone or in combination adversely affect the kidney

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis and high phosphate (HP) intake can negatively affect the kidney in the presence of renal disease. This study aimed to evaluate the effects of periodontitis or HP intake, either alone or concurrently, on the periodontal tissue and the kidney under normal renal conditions.
Ae Ri Kim, Min Seo Kim, Jiwon Seo, Eun‐Jung Bak, Yun‐Jung Yoo   +4 more
wiley   +1 more source

Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy

JCI Insight, 2022
Aristolochic acid nephropathy (AAN) is characterized by acute proximal tubule necrosis and immune cell infiltration, contributing to the global burden of chronic kidney disease and urothelial cancer.
Jiayun Chen, Piao Luo, Chen Wang, Chuanbin Yang, Yunmeng Bai, Xueling He, Qian Zhang, Junzhe Zhang, Jing Yang, Shuang Wang, Jigang Wang   +10 more
doaj   +1 more source

Aristolochic acid-associated urothelial cancer in Taiwan [PDF]

Proceedings of the National Academy of Sciences, 2012
Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation, aristolochic acid reacts with DNA to form aristolactam (AL)-DNA adducts.
Chung-Hsin, Chen, Kathleen G, Dickman, Masaaki, Moriya, Jiri, Zavadil, Viktoriya S, Sidorenko, Karen L, Edwards, Dmitri V, Gnatenko, Lin, Wu, Robert J, Turesky, Xue-Ru, Wu, Yeong-Shiau, Pu, Arthur P, Grollman   +11 more
openaire   +2 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Recognition of the toxicity of aristolochic acid [PDF]

Journal of Clinical Pharmacy and Therapeutics, 2018
Aristolochic acid (AA) is an abundant compound in Aristolochia plants and various natural herbs. In the 1990s, a slimming formula used in Belgium that contains Aristolochia fangchi was reported to cause kidney damage and bladder cancer, and aristolochic acid nephropathy (AAN) is now well recognized worldwide. In October 2017, researchers reported an AA
Hong-Mei, Zhang, Xiao-Hu, Zhao, Zhi-Hui, Sun, Gui-Chen, Li, Guang-Chen, Liu, Li-Rui, Sun, Ji-Qiu, Hou, Wei, Zhou   +7 more
openaire   +2 more sources

Linkage disequilibrium score regression identifies genetic correlations between hepatocellular carcinoma and clinically relevant traits

International Journal of Cancer, Volume 158, Issue 5, Page 1193-1203, 1 March 2026.
What's New? Hepatocellular carcinoma arises from a combination of environmental and genetic factors, with the latter playing a potentially more significant role in nonviral hepatocellular carcinoma. Here, the authors characterized the genetic correlations and heritability between nonviral hepatocellular carcinoma and 901 epidemiologic, behavioral, and ...
Younghun Han, Vikram R. Shaw, Jinyoung Byun, Aaron P. Thrift, Catherine Zhu, Donghui Li, Rikita I. Hatia, Robin Kate Kelley, Sean P. Cleary, Anna S. Lok, Paige M. Bracci, Jennifer B. Permuth, Roxana Bucur, Jennifer Knox, Jian‐Min Yuan, Amit G. Singal, Prasun K. Jalal, R. Mark Ghobrial, Yuko Kono, Dimpy P. Shah, Mindie H. Nguyen, Neehar D. Parikh, Richard Kim, Hui‐Chen Wu, Hashem El‐Serag, Ping Chang, Yun Shin Chun, Jian Gu, Chad Huff, Asif Rashid, Lu‐Yu Hwang, Alison P. Klein, Saira A. Khaderi, Ahmed O. Kaseb, Kathrine A. McGlynn, Lewis R. Roberts, Manal M. Hassan, Christopher I. Amos   +37 more
wiley   +1 more source

Approach to the Interaction Studies of Aristolochia maxima and the Caterpillars of Butterflies Battus polydamas polydamas and Parides panares erythrus

Acta Biológica Colombiana, 2007
Most butterflies of the tribe Troidini (Lepidoptera: Papilionidae) sequester aristolochic acids (AA) for their protection. These acids are derived from their host plants -family Aristolochiaceae- upon which they feed on during their larval stages.
Ricardo A. Claro, Hebelin Correa, Carmenza Duque, Natalia Ruiz   +3 more
doaj  

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Chemical Constituents and Pharmacology properties of Aristolochia triangularis: a south brazilian highly-consumed botanical with multiple bioactivities

Anais da Academia Brasileira de Ciências
: Aristolochia triangularis Cham., is one of the most frequently used medicinal plant in Southern Brazil. Preparations containing the leaves and/or stems are traditionally used as anti-inflammatory, diuretic, as well as antidote against snakebites.
SIMONE Q. OLIVEIRA, JADEL M. KRATZ, VITOR C. CHAVES, TATIANA R. GUIMARÃES, DANIELLE T.M. COSTA, SAPFO DIMITRAKOUDI, ARGYRO VONTZALIDOU, SÉRGIO A.L. BORDIGNON, CESAR P. SIMIONATO, MÁRIO STEINDEL, FLÁVIO H. REGINATTO, CLÁUDIA M.O. SIMÕES, ELOIR P. SCHENKEL   +12 more
doaj   +1 more source