Results 61 to 70 of about 817,904 (149)

Delineation of renal protein profiles in aristolochic acid I-induced nephrotoxicity in mice by label-free quantitative proteomics

Frontiers in Pharmacology
Introduction: Aristolochic acid nephropathy (AAN) is a kidney injury syndrome caused by aristolochic acids exposure. Our study used label-free quantitative proteomics to delineate renal protein profiles and identify key proteins after exposure to ...
Xinhui Liu, Shanshan Wu, Shanshan Wu, Yu Peng, Yu Peng, Liwen Gao, Liwen Gao, Xi Huang, Xi Huang, Ruyu Deng, Ruyu Deng, Jiandong Lu   +11 more
doaj   +1 more source

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
wiley   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Sequestration of aristolochic acids from meridic diets by larvae of Battus polydamas archidamas (Papilionidae: Troidini)

European Journal of Entomology, 2011
Larvae of the butterfly, Battus polydamas archidamas (Papilionidae: Troidini) feed exclusively on aristolochic acid (AAs)-containing Aristolochia species (Aristolochiaceae).
Carlos F. PINTO, Alejandro URZÚA, Hermann M. NIEMEYER   +2 more
doaj   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, Volume 6, Issue 3, March 2026.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

The Occurrence Of Aristolochic Acids In Neotropical Troidine Swallowtails (lepidoptera: Papilionidae)

, 2015
Analysis of individuals of 17 troidine species demonstrated the presence of aristolochic acids in these butterflies in varying concentrations. Although aristolochic acids do not occur in Aristolochia galeala leaves, they were present in Battus polydamas ...
Klitzke C.F., Brown Jr. K.S.
core   +1 more source

Mitochondrial Dysfunction in Aristolochic Acid I-Induced Kidney Diseases: What We Know and What We Do Not Know

Applied Sciences
Aristolochic acids, compounds derived from Aristolochiaceae plant species, are associated with significant renal nephrotoxicity and carcinogenicity. Aristolochic acid I (AAI), the most predominant and potent of these compounds, is a primary etiological ...
Alexandra T. Lukinich-Gruia, Crenguta L. Calma, Flavia A. E. Szekely, Iustina-Mirabela Cristea, Maria-Alexandra Pricop, Alina-Georgiana Simina, Valentin L. Ordodi, Nikola M. Pavlović, Calin A. Tatu, Virgil Paunescu   +9 more
doaj   +1 more source

Involvement of phospholipase A2 in the release of silymarin to the culture medium of Silybum marianum cell suspensions

Biologia Plantarum, 2014
In suspension cell cultures of Silybum marianum, methyl jasmonate (MJ) stimulated the accumulation and release of silymarin (Sm) to the culture medium. This study shows that phospholipase A2 (PLA2) plays a role in the release of Sm in elicited cultures ...
P. Corchete, J. Fernandez-Tarrago
doaj   +1 more source

BK virus‐associated urothelial carcinoma—A supra‐regional cohort of kidney transplant recipients

BJUI Compass, Volume 7, Issue 3, March 2026.
Abstract Objectives This study aims to study the clinical features, pathological findings, and outcomes of BK virus‐associated urothelial carcinoma (UC) in kidney transplant recipients (KTRs). Patients and Methods The study was conducted in a retrospective cohort of KTRs with histologically confirmed UC managed at a UK supra‐regional transplant urology
Noah Beetge, Luis Ribeiro, Rhana Zakri, Catherine Horsfield, Jonathon Olsburgh   +4 more
wiley   +1 more source

Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis [PDF]

, 2014
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Schroeder, N, Johnson, TS, Verderio, EAM, Funck, M, Scarpellini, A, Burhan, I, Huang, L   +6 more
core   +1 more source