Results 61 to 70 of about 4,033 (193)

Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair

Advanced Science, Volume 13, Issue 3, 14 January 2026.
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang, Shi‐Hao Bai, Shu‐Jin Song, Xiao‐Li Zhang, Xue‐Ying Shang, Zhao‐Ning Lu, Xiao‐Fang Cui, Xin‐Le Zhu, Ze‐Guang Han   +8 more
wiley   +1 more source

Delineation of renal protein profiles in aristolochic acid I-induced nephrotoxicity in mice by label-free quantitative proteomics

Frontiers in Pharmacology
Introduction: Aristolochic acid nephropathy (AAN) is a kidney injury syndrome caused by aristolochic acids exposure. Our study used label-free quantitative proteomics to delineate renal protein profiles and identify key proteins after exposure to ...
Xinhui Liu, Shanshan Wu, Shanshan Wu, Yu Peng, Yu Peng, Liwen Gao, Liwen Gao, Xi Huang, Xi Huang, Ruyu Deng, Ruyu Deng, Jiandong Lu   +11 more
doaj   +1 more source

Involvement of phospholipase A2 in the release of silymarin to the culture medium of Silybum marianum cell suspensions

Biologia Plantarum, 2014
In suspension cell cultures of Silybum marianum, methyl jasmonate (MJ) stimulated the accumulation and release of silymarin (Sm) to the culture medium. This study shows that phospholipase A2 (PLA2) plays a role in the release of Sm in elicited cultures ...
P. Corchete, J. Fernandez-Tarrago
doaj   +1 more source

Identification of a Reduction Product of Aristolochic Acid: Implications for the Metabolic Activation of Carcinogenic Aristolochic Acid [PDF]

Journal of Natural Products, 2010
Aristolochic acids are nephrotoxic and carcinogenic natural products that have been implicated both in endemic nephropathy in the Balkan region and in ailments caused by ingestion of herbal remedies. Aristolochic acids are metabolized to active intermediates that bind to DNA.
Horacio A, Priestap, Carlos, de los Santos, J Martin E, Quirke   +2 more
openaire   +2 more sources

Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice [PDF]

, 2023
Yaping Dong, Shuzhen Chen, Huisi He, Zhuoran Sun, Li-xuan Jiang, Yanqiu Gu, Ying Zhang, Fei Feng, Chun Chen, Zhecai Fan, Xiaofei Chen, Wen Wen, Hongyang Wang   +12 more
openalex   +1 more source

MicroRNA‐382 Is Involved in Acute Kidney Injury via Regulating STAT1 Signaling

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Acute kidney injury (AKI), characterized by inflammation and oxidative stress, is a life‐threatening clinical presentation. We previously demonstrated the role of miR‐382 in the progression of chronic kidney disease (CKD). However, the role of miR‐382 in AKI is unknown.
Xiaoyan Wang, Guo Cheng, Ting Ren, Zhouping Zou, Xinni Zhang, Shuan Zhao, Siyu Bao, Yingxiang Li, Ping Jia, Yi Fang, Xiaoqiang Ding, Poorani Gurumallesh   +11 more
wiley   +1 more source

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Mitochondrial Dysfunction in Aristolochic Acid I-Induced Kidney Diseases: What We Know and What We Do Not Know

Applied Sciences
Aristolochic acids, compounds derived from Aristolochiaceae plant species, are associated with significant renal nephrotoxicity and carcinogenicity. Aristolochic acid I (AAI), the most predominant and potent of these compounds, is a primary etiological ...
Alexandra T. Lukinich-Gruia, Crenguta L. Calma, Flavia A. E. Szekely, Iustina-Mirabela Cristea, Maria-Alexandra Pricop, Alina-Georgiana Simina, Valentin L. Ordodi, Nikola M. Pavlović, Calin A. Tatu, Virgil Paunescu   +9 more
doaj   +1 more source

Acute nephrotoxicity of aristolochic acids in mice

Journal of Pharmacy and Pharmacology, 2004
Abstract Aristolochic acids (AA), present in Aristolochia plants, are the toxin responsible for Chinese herbs nephropathy (CHN), a rapidly progressive tubulointerstitial nephritis (TIN). To clarify the mechanisms of the development of CHN, we tried to induce TIN in mice using AA.
Noriko, Sato, Daisuke, Takahashi, Shih-Ming, Chen, Reiko, Tsuchiya, Takuya, Mukoyama, Shin-ichi, Yamagata, Makoto, Ogawa, Masaaki, Yoshida, Seizo, Kondo, Nobunori, Satoh, Shiro, Ueda   +10 more
openaire   +2 more sources

Advances in Conductive Nanomaterials for Cardiac Arrhythmia and Future Directions in Bioevaluation Strategies

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
Conductive nanomaterials (CNMs) show promising potential in cardiac tissue regeneration and restoring cardiac rhythm as reported in several in vitro studies. This review article elaborates on the applications of CNMs in the treatment of myocardial infarction (MI) and MI‐induced cardiac arrhythmias, and it sheds light on the innovative approach of ...
Sumithra Y. Srinivasan, Anna Laromaine
wiley   +1 more source