Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif containing ciliary targeting sequence [PDF]
Journal of Biological Chemistry, 2023 Divyanshu Mahajan
exaly +2 more sources
Cilia proteins are biomarkers of altered flow in the vasculature [PDF]
JCI Insight, 2022 Cilia, microtubule-based organelles that project from the apical luminal surface of endothelial cells (ECs), are widely regarded as low-flow sensors. Previous reports suggest that upon high shear stress, cilia on the EC surface are lost, and more recent ...
Ankan Gupta +14 more
doaj +3 more sources
A cell-autonomous role for primary cilium-mediated signaling in long-range commissural axon guidance [PDF]
DevelopmentCiliopathies are characterized by the absence or dysfunction of primary cilia. Despite the fact that cognitive impairments are a common feature of ciliopathies, how cilia dysfunction affects neuronal development has not been characterized in detail. Here,
Dumoulin, Alexandre +3 more
core +2 more sources
Shared and unique consequences of Joubert Syndrome gene dysfunction on the zebrafish central nervous system [PDF]
Biol OpenJoubert Syndrome (JBTS) is a neurodevelopmental ciliopathy defined by a highly specific midbrain-hindbrain malformation, variably associated with additional neurological features.
Bachmann-Gagescu, Ruxandra +11 more
core +2 more sources
Single‐nuclei RNA‐Sequencing of Postmortem Choroid Plexus Uncovers Dysfunction Alzheimer’s disease [PDF]
Alzheimer's &Dementia, Volume 20, Issue S8, December 2024.Abstract Background The choroid plexus (ChP) is formed by epithelial cells and stromal fibroblasts which act as a blood‐cerebrospinal fluid (CSF) barrier, play a key role in maintaining brain homeostasis, and provide a niche for immune cells. ChP dysfunction has been implicated in Alzheimer’s Disease (AD), including changes in CSF secretion, increased ...
Tristan J Philippe +8 more
wiley +2 more sources
Developmental Biology, 2014 Cilia perform a variety of functions in a number of developmental and physiological contexts, and are implicated in the pathogenesis of a wide spectrum of human disorders. While the ciliary axoneme is assembled by intraflagellar transport, how ciliary membrane length is regulated is not completely understood.
Hao Lu +5 more
openalex +4 more sources
Aurora kinase A inhibition plus Tumor Treating Fields suppress glioma cell proliferation in a cilium-independent manner [PDF]
Translational OncologyTumor Treating Fields (TTFields) extend the survival of glioblastoma (GBM) patients by interfering with a broad range of tumor cellular processes. Among these, TTFields disrupt primary cilia stability on GBM cells.
Jia Tian +7 more
doaj +2 more sources
Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration [PDF]
Journal of Cell Science, 2019 ABSTRACT Mutations in the Abelson-helper integration site 1 (AHI1) gene are associated with neurological/neuropsychiatric disorders, and cause the neurodevelopmental ciliopathy Joubert syndrome (JBTS). Here, we show that deletion of the transition zone (TZ) protein Ahi1 in mouse embryonic fibroblasts (MEFs) has a small effect on cilia ...
Jesús Muñoz-Estrada +1 more
openaire +3 more sources
ARL3 activation requires the co-GEF BART and effector-mediated turnover
eLife, 2021 The ADP-ribosylation factor-like 3 (ARL3) is a ciliopathy G-protein which regulates the ciliary trafficking of several lipid-modified proteins. ARL3 is activated by its guanine exchange factor (GEF) ARL13B via an unresolved mechanism.
Yasmin ElMaghloob +5 more
doaj +1 more source
Identification of Cilia in Different Mouse Tissues
Cells, 2021 Cilia are microtubule-based hair-like organelles that extend from the cell surface. However, the existence and distribution of cilia in each organ and tissue at the postnatal stage in vivo remain largely unknown.
Xinhua Li +4 more
doaj +1 more source