Results 81 to 90 of about 56,011 (338)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Silencers: A Threat to Public Safety [PDF]

open access: yes, 2017
A push by the firearms industry and gun lobby to make it far easier for private citizens to buy and possess firearm silencers will only place the police and public at increased risk warns a new and expanded edition of the Violence Policy Center's (VPC ...

core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Assessment of quality of matériel procured for the Yugoslav Army

open access: yesVojnotehnički Glasnik, 1995
After an analysis of the overall state of affairs in the domain of ensuring the quality of materiel being procured for its needs, carried out by the end of the eighties, the Yugoslav Army assessed that the then existing regulations were not sufficient ...
Ratomir Stanojlović
doaj   +1 more source

Armament Imbalances: Match and Mismatch in Plant-Pollinator Traits of Highly Specialized Long-Spurred Orchids

open access: yesPLoS ONE, 2012
Background Some species of long-spurred orchids achieve pollination by a close association with long-tongued hawkmoths. Among them, several Habenaria species present specialized mechanisms, where pollination success depends on the attachment of ...
M. Moré   +5 more
semanticscholar   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sonoactivated Nanomaterials: A potent armament for wastewater treatment

open access: yesUltrasonics sonochemistry, 2023
Jianfeng Bao   +5 more
semanticscholar   +1 more source

“One More for Luck”: The Destruction of U971 by HMCS Haida and HMS Eskimo, 24 June 1944 [PDF]

open access: yes, 2012
On the evening of 23 June 1944, HMCS Haida and HMS Eskimo set out from Plymouth, operational base of the 10th Destroyer Flotilla (10th DF), to conduct a sweep of the Western Approaches to the English Channel.
Gough, Barry M., Woods, James A.
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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