Results 81 to 90 of about 1,846,966 (339)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Introducing the Spatial Conflict Dynamics indicator of political violence
, 2020 Modern armed conflicts have a tendency to cluster together and spread geographically. However, the geography of most conflicts remains under-studied. To fill this gap, this article presents a new indicator that measures two key geographical properties of
Radil, Steven M. +3 more
core
Quintessential Elements of Meaningful Constitutions in Post-Conflict States [PDF]
, 2008 This examination compares several successful constitutions formulated to govern countries just formed from the conclusion of armed conflicts (including the U.S.).
Van Alstyne, William W.
core +2 more sources
Inequality in Death from Social Conflicts: A Gini & Kolkata indices-based Study
, 2019 Human deaths caused by individual man-made conflicts (e.g., wars, armed-conflicts, terrorist-attacks etc.) occur unequally across the events (conflicts) and such inequality (in deaths) have been studied here using Lorenz curve and values of the ...
Chakrabarti, Bikas K., Sinha, Antika
core +1 more source
‘New’ and ‘old’ wars – the changing dimensions of warfare [PDF]
, 2018 The article aims to present the issue of ‘old’ versus ‘new’ wars in relation to their specific features. It focuses on the characteristics of both phenomena, as well as providing an analysis of the causes and sources of armed conflicts and their changing
Antczak, Anna
core +3 more sources
Internationalized Armed Conflicts in International Law
Oxford Scholarship Online, 2018 This book examines and analyses the concept, the process, and the consequences of conflict internationalization from the perspective of international law.
K. Mačák
semanticscholar +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Journalistic Discourse of Modern Armed Conflicts: Features of Formation and Functioning [PDF]
, 2017 The Russian journalistic discourse of modern armed conflicts as a special type of a journalistic discourse is considered. The classifying lines of a journalistic discourse of modern armed conflicts are distinguished.Рассматривается российский ...
Amirov, V. M, Амиров, В. М.
core
Tensions and armed conflicts worldwide: a geopolitical perspective [PDF]
, 2011 El nuevo orden geopolítico mundial posterior al final de la Guerra Fría y que se corresponde con el actual proceso de globalización ha transformado la morfología, localización, causas y tipos de impactos generados por los conflictos armados, así como los
Méndez Gutiérrez del Valle, Ricardo
core +3 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source