Results 111 to 120 of about 665,294 (217)

Formestane, a steroidal aromatase inhibitor after failure of non-steroidal aromatase inhibitors (anastrozole and letrozole): is a clinical benefit still achievable?

, 2001
There are few clinical data on the sequential use of aromatase inhibitors (AI). This paper focuses on the relevance of clinical benefit CB (CR + PR + SD > or = 6 months) in postmenopausal metastatic breast cancer (MBC) patients treated with the steroidal
Cognetti, F., Casali, A, Fabi, A, Ruggeri, E. M, Papaldo, P, Nardi, M, Carlini, P, De Marco, S, Paoloni, F, FRASSOLDATI, Antonio   +9 more
core   +1 more source

Neoplastic Risk in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Besides gonadal involvement (hypogonadism, male factor infertility, and testicular hypotrophy), patients with Klinefelter syndrome (KS) may suffer from several extra‐gonadic complications, including neoplastic events. Objective The aim of this review is to summarize all major clinical evidence dealing with the association between KS
Andrea Graziani, Giuseppe Grande, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +4 more
wiley   +1 more source

Mammalian sperm quality and aromatase expression

, 2009
SynthèseInternational audienceIn most mammalian species the aromatase is encoded by a single gene (cyp19), which contains 18 exons, 9 of them being translated.
Delalande, Christelle, Christelle Delalande, Serge Carreau, Isabelle Galeraud‐Denis, Carreau, Serge, Galeraud-Denis, Isabelle   +5 more
core   +1 more source

Effect of Testosterone Treatment on Leucocyte Telomere Length in Men: Results From a Randomised Placebo‐Controlled Trial

Andrology, EarlyView.
ABSTRACT Background Lower testosterone concentrations in older men are associated with poorer health outcomes. Objective We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing, in overweight men with impaired glucose tolerance (IGT) or newly ...
Bu B. Yeap, Jennie Hui, Kristy P. Robledo, Gillian Arscott, Mathis Grossmann, David J. Handelsman, Warrick J. Inder, Bronwyn G. A. Stuckey, Alicia J. Jenkins, Karen Bracken, John P. Beilby, Gary A. Wittert   +11 more
wiley   +1 more source

Association of Fat Body Mass With Vertebral Fractures in Postmenopausal Women With Early Breast Cancer Undergoing Adjuvant Aromatase Inhibitor Therapy

, 2019
Importance: Aromatase inhibitors induce a profound depletion in serum estrogen levels. Postmenopausal obese women receiving aromatase inhibitor therapy may be at increased risk of bone fractures owing to the detrimental association of adiposity with bone
Rodella F., Pedersini R., Maffezzoni F., Monteverdi S., Simoncini E. L., Maroldi R., TURLA, ANTONELLA, Ardine M., Giustina A., Ravanelli M., Gallo F., Berruti A., Dalla Volta A., Vassalli L., Formenti A. M., Amoroso V.   +15 more
core   +1 more source

Bone Health and Aging in Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Klinefelter syndrome (KS) is typically diagnosed in young adults, but advances in prenatal testing have led to its recognition at a much earlier age. Conversely, diagnosis in late adulthood remains uncommon, but still occurs. Independently from the age at diagnosis, KS individuals now receive more accurate and tailored care management than in ...
Filippo Vignali, Daniele Renda Livraghi, Francesco Costantino, Sara De Vincentis, Vincenzo Rochira   +4 more
wiley   +1 more source

Androgens Modulate Tumor–Immune Interactions in Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The majority of testicular germ cell tumors (TGCT) are derived from the germ cell neoplasia in situ and arise after puberty in the local presence of high levels of testosterone. The seminoma subtype features a rich inflammatory infiltrate which impacts tumor progression but the role of testosterone in shaping tumor–immune ...
Ida Hamann, Lucas Klaus, Patrick Fruth, Alexander Fichtner, Tobias J. Legler, Holger M. Reichardt, Fabian A. Gayer   +6 more
wiley   +1 more source

A Case for the Use of Combined Hormonal Therapy for Aggressive Angiomyxoma: Complete Response to Goserelin and Letrozole Following Incomplete Surgical Resection

Clinical Case Reports
We report on the use of combined hormonal therapy with a gonadotropin releasing hormone antagonist and aromatase inhibitor in pelvic aggressive angiomyxoma, with a complete response.
George Mallat, Annabelle Farnsworth, Florian Honeyball, Michael Solomon, Peter Grimison   +4 more
doaj   +1 more source

Clinical Relevance of the SOUND and INSEMA Trials in Women With Early Breast Cancer in Australia and New Zealand

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Axillary surgery in breast cancer has undergone progressive de‐escalation. The recent Sentinel Node versus Observation after Axillary Ultrasound (SOUND) and Intergroup Sentinel Mamma (INSEMA) trials have demonstrated that sentinel lymph node biopsy may be safely omitted in selected patients. This study aimed to evaluate the clinical
Matea Dominkovic, Kerry Hitos, Wei Wang, T. Michael Hughes, James French, Nicholas Ngui   +5 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source