Results 121 to 130 of about 56,186 (320)

A pilot study of gonadotropin-releasing hormone agonist combined with aromatase inhibitor as fertility-sparing treatment in obese patients with endometrial cancer [PDF]

, 2019
Zhibo Zhang, Huifang Huang, Fengzhi Feng, Jinhui Wang, Ninghai Cheng   +4 more
openalex   +1 more source

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source

Comparative study of the efficacy of tamoxifen and aromatase inhibitors among breast cancer patients at Kenyatta National Hospital

Journal of the Egyptian National Cancer Institute
Background Aromatase inhibitors have demonstrated superior outcomes compared to tamoxifen in various studies. However, research in Africa, including Kenya, where breast cancer mortality rates are disproportionately high, is lacking.
Henry Gachoki Macharia, Amsalu Degu
doaj   +1 more source

Aromatase Inhibitors and Newly Developed Nonalcoholic Fatty Liver Disease in Postmenopausal Patients with Early Breast Cancer: A Propensity Score-Matched Cohort Study [PDF]

, 2019
Jung Il Lee, Jung Hwan Yu, Sung Gwe Anh, Hyun Woong Lee, Joon Jeong, Kwan Sik Lee   +5 more
openalex   +1 more source

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

Central Precocious Puberty as a Complication of Therapy with Adrenocorticotropin (ACTH) and an Aromatase Inhibitor for Refractory Nephrotic Syndrome

Case Reports in Pediatrics, 2019
Glucocorticoids are typically prescribed for the treatment of idiopathic nephrotic syndrome of childhood. In selected patients with refractory focal segmental glomuerulosclerosis (FSGS), adrenocorticotropin (ACTH) can be used to induce remission and ...
Sungeeta Agrawal, Robert Gensure, Lawrence Milner, Julie Nicoletta, Abdollah Sadeghi-Nejad   +4 more
doaj   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Panorama actual de los inhibidores de la aromatasa en la inducción de la ovulación Current view of aromatase inhibitors in ovulation induction

Revista Colombiana de Obstetricia y Ginecología, 2007
El panorama actual de la inducción de la ovulación en el tratamiento de la infertilidad está cambiando debido a la introducción reciente en este campo de los inhibidores de la aromatasa de tercera generación (IA).
Natalia Posada-Villa, Juan de Jesús Pachón-Rincón   +1 more
doaj  

Comparison of gonadotropin releasing hormone agonists (GNRHA) vs aromatase inhibitors on volume of uterine leiomyomas in premenopausal women

Journal of Contemporary Pharmacy, 2023
Among the most prevalent yet poorly understood female health issues is uterine leiomyomas. In order to preserve fertility and avoid or delay surgical intervention, medical treatments are typically considered first-line.
Uzma Hussain, Netasha Nazar, Muhammad Essa, Uswah Shoiab, Maria Imran, Fatima Waheed, Huma Khan   +6 more
doaj  

Treatment of Men with Idiopathic Oligozoospermic Infertility Using the Aromatase Inhibitor, Testolactone Results of a Double‐Blinded, Randomized, Placebo‐Controlled Trial with Crossover [PDF]

, 1989
Richard V. Clark, Richard J. Sherins
openalex   +1 more source