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Aromatase inhibitors—Socioeconomical issues
The Journal of Steroid Biochemistry and Molecular Biology, 2005Novel, third-generation aromatase inhibitors are currently implemented for treatment of postmenopausal breast cancer in the metastatic and adjuvant setting and, potentially, for breast cancer prevention. Introduction of novel therapeutic strategies to large patient groups may add significant costs to health care budgets, forcing institutions to focus ...
Per E, Lønning, Jürgen, Geisler
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Annals of the New York Academy of Sciences, 2006
Abstract: Aromatase is the enzyme synthesizing estrogens from androgens. In estrogen‐dependent breast tumors, estrogens induce the expression of growth factors responsible for cancer cell proliferation. In situ estrogen synthesis by aromatase “is thought to play a key role in the promotion of breast cancer growth.
Yanyan, Hong, Shiuan, Chen
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Abstract: Aromatase is the enzyme synthesizing estrogens from androgens. In estrogen‐dependent breast tumors, estrogens induce the expression of growth factors responsible for cancer cell proliferation. In situ estrogen synthesis by aromatase “is thought to play a key role in the promotion of breast cancer growth.
Yanyan, Hong, Shiuan, Chen
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Expert Opinion on Therapeutic Patents, 2002
Endocrine treatment is at the core of therapies against early and advanced breast cancer. Modulators of the estrogen receptor have monopolized the field, offering durable clinical responses with an excellent tolerability profile. The benefits of endocrine therapy, however, are limited to estrogen receptor positive patients.
Simonida Grubjesic +2 more
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Endocrine treatment is at the core of therapies against early and advanced breast cancer. Modulators of the estrogen receptor have monopolized the field, offering durable clinical responses with an excellent tolerability profile. The benefits of endocrine therapy, however, are limited to estrogen receptor positive patients.
Simonida Grubjesic +2 more
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Aromatase, Aromatase Inhibitors, and Breast Cancer
American Journal of Therapeutics, 2001Estrogens are involved in numerous physiologic processes and have crucial roles in particular disease states, such as mammary carcinomas. Estradiol, the most potent endogenous estrogen, is biosynthesized from androgens by the cytochrome P-450 enzyme complex called aromatase.
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Arthralgia and aromatase inhibitors
Joint Bone Spine, 2014Joint Bone Spine - In Press.Proof corrected by the author Available online since mercredi 14 aout ...
Daniel, Wendling +4 more
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Bulletin du cancer, 1999
Aromatase inhibitors used in breast cancer, are drugs that inhibit the transformation of androstenedione and testosterone, respectively in estradiol and estrone. Two classes have been described: steroidal inhibitors which act competitively and irreversibly and non steroidal inhibitors which block the P 450 cytochrome. The first one is aminoglutethimide
M L, Feutrie, J, Bonneterre
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Aromatase inhibitors used in breast cancer, are drugs that inhibit the transformation of androstenedione and testosterone, respectively in estradiol and estrone. Two classes have been described: steroidal inhibitors which act competitively and irreversibly and non steroidal inhibitors which block the P 450 cytochrome. The first one is aminoglutethimide
M L, Feutrie, J, Bonneterre
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The Journal of Steroid Biochemistry and Molecular Biology, 1999
Inhibitors of aromatase (estrogen synthetase) have been developed as treatment for postmenopausal breast cancer. Both steroidal substrate analogs, type I inhibitors, which inactivate the enzyme and non-steroidal competitive reversible, type II inhibitors, are now available.
A, Brodie, Q, Lu, B, Long
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Inhibitors of aromatase (estrogen synthetase) have been developed as treatment for postmenopausal breast cancer. Both steroidal substrate analogs, type I inhibitors, which inactivate the enzyme and non-steroidal competitive reversible, type II inhibitors, are now available.
A, Brodie, Q, Lu, B, Long
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Aromatase inhibitors for chemoprevention
Best Practice & Research Clinical Endocrinology & Metabolism, 2004Pre-clinical, molecular and epidemiological evidence supports a role for estrogen in both the initiation and promotion of breast cancer. Antagonizing estrogen has therefore been proposed as one way of reducing risk. Tamoxifen, which competes with estrogen at the estrogen receptor, has been shown in four phase III clinical trials to reduce tumour ...
Paul E, Goss, Kathrin, Strasser-Weippl
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Aromatase inhibitors: Future directions
The Journal of Steroid Biochemistry and Molecular Biology, 2005Estrogen and its cognate estrogen receptor are key players in the etiology and progression of breast cancer. Aromatase inhibitors, suppressing tumor and plasma estrogen levels by blocking testosterone conversion to estrogen, have been proven to provide the most effective endocrine therapy for postmenopausal breast cancer patients.
C Kent, Osborne, Rachel, Schiff
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Toxicity of Aromatase Inhibitors
Seminars in Oncology, 2006Adjuvant hormonal therapy in hormone receptor-positive breast cancer is used for the prevention of disease recurrence and prolongation of survival. Aromatase inhibitors are increasingly being used for this purpose. Numerous studies now reveal their benefits over tamoxifen while demonstrating a markedly different toxicity profile.
Pandya, Naushira, Morris, G J
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