Results 51 to 60 of about 57,705 (278)

Statistical Discrimination of Urinary Steroid Biomarkers in the Athlete Biological Passport: A Novel Approach to an Abnormal Steroid Profile Score (ASPS)

Drug Testing and Analysis, EarlyView.
The study developed a single Abnormal Steroid Profile Score (ASPS) to improve interpretation of the Athlete Biological Passport steroid module. Using Bayesian modelling and logistic regression, biomarker patterns from laboratory and doping control data successfully discriminated between doped and clean individuals, with improved classification ...
James G. Hopker, Jim E. Griffin, Matthew N. Fedoruk, Laura A. Lewis   +3 more
wiley   +1 more source

The use of aromatase inhibitors in boys with short stature: what to know before prescribing?

Archives of Endocrinology and Metabolism
Aromatase is a cytochrome P450 enzyme (CYP19A1 isoform) able to catalyze the conversion of androgens to estrogens. The aromatase gene mutations highlighted the action of estrogen as one of the main regulators of bone maturation and closure of bone plate.
Alessandra Linardi, Durval Damiani, Carlos A. Longui   +2 more
doaj   +1 more source

QSAR analysis of some azole derivatives as potent aromatase inhibitors [PDF]

Trends in Pharmaceutical Sciences, 2018
A high proportion of breast tumors are hormone-dependent, implying that endogenous estrogens play a critical role in cancer cell proliferation. One of the most effective strategies for the treatment of breast cancer is reduction of estrogens level by ...
Razeih Sabet, Soghra Khabnadideh, Samaneh Mohseni, Ayyub Mojaddami, Zahra Rezaei   +4 more
doaj  

Whole Body Vibration Exposure on Markers of Bone Turnover, Body Composition, and Physical Functioning in Breast Cancer Patients Receiving Aromatase Inhibitor Therapy: A Randomized Controlled Trial

Integrative Cancer Therapies, 2018
Introduction: Women with breast cancer are often prescribed aromatase inhibitors, which can cause rapid loss of bone mass leading to significant potential for morbidity.
Michael K. Baker PhD, Carolyn J. Peddle-McIntyre PhD, Daniel A. Galvão PhD, Catherine Hunt AD, Nigel Spry MBBS, PhD, Robert U. Newton PhD   +5 more
doaj   +1 more source

DETERMINATION OF LETROZOLE, ANASTROZOLE AND EXEMESTANE BY CAPILLARY ZONE ELECTROPHORESIS

Studia Universitatis Babes-Bolyai Chemia, 2017
A new validated capillary zone electrophoresis method was developed for the quantification of three aromatase inhibitors - anastrozole, letrozole and exemestane.
Aura RUSU, Gabriel HANCU, Lavinia-Anda BERȚA, Camil Eugen VARI   +3 more
doaj   +1 more source

Male breast cancer [PDF]

, 2017
Male breast cancer (MBC) is a rare disease representing less than 1% of all breast cancers (BC) and less than 1% of cancers in men. Age at presentation is mostly in the late 60s.
A Bjørnerem, A Holleb, A Jemal, AC Antoniou, AM Shaaban, B D'Avanzo, Breast Cancer Linkage Consortium, C Gómez-Raposo, C Martinez-Bouzas, C Rudlowski, D Albo, D Ly, D Palli, DA Rigoni-Stern, DG Evans, DS Popovic, E Kreiter, EF Lewison, G Masci, G Ribeiro, GR Brown, I Ganly, I Sosnovskikh, I Zanna, IS Fentiman, IS Fentinam, J Boyd, J White, JD Fackenthal, JH Breasted, JL Gnerlich, JR Weiss, K Coard, K Syrjakoski, KA Johansen Taber, KD Crew, L France, L Ottini, L Ottini, LA Brinton, LA Brinton, LA Brinton, LA Brinton, LA Brinton, LA Korde, M Falchetti, M Golshan, MA Adank, MB Cook, ME Meijer-van Gelder, MM Munoz de Toro, MT Vietri, N Orr, N Rahman, O Gentilini, P Karamanakos, RM Ferzoco, S Paik, S Peng, S Shak, S Thorlacious, SH Giordano, SH Giordano, SH Giordano, T Grenader, V Silvestri, V Silvestri, V Speirs, WF Anderson, WF Anderson, Y Ge, ZI Mitri   +71 more
core   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Bilateral De Quervain Syndrome after Aromatase Inhibitor Administration: A Case Report and Review of the Literature

Case Reports in Medicine, 2012
Aromatase inhibitors are widely used as one of the main treatment options of both early and advanced hormone receptor-positive breast cancer in postmenopausal women.
Konstantinos Papadimitriou, Panteleimon Kountourakis, Emmanouil Morakis, Vassilios Vassiliou, Vasileios Barbounis, Alexandros Ardavanis   +5 more
doaj   +1 more source

A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]

, 2011
Background The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.
Wang, J.Z., Deogan, M.S., Lewis, J.R., Chew, S., Mullin, B.H., McNab, T.J., Wilson, S.G., Ingley, E., Prince, R.L.   +8 more
core   +3 more sources

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source