Results 41 to 50 of about 203,869 (259)
Acta Medica, 2000 Decarboxylation of aromatic amino acid in mammalian tissues is catalyzed by aromatic amino acid decarboxylase (EC. 4.1.1.28, AAD). The enzyme differs in its affinity to individual aromatic amino acids, the best substrates being 3,4-dihydroxyphenylalanine
Jaroslav Dršata, Eliška Marklová
doaj +1 more source
Plasma Amino Acid Concentrations Predict Mortality in Patients with End-Stage Liver Disease. [PDF]
PLoS ONE, 2016 The liver plays a key role in amino acid metabolism. In former studies, a ratio between branched-chain and aromatic amino acids (Fischer's ratio) revealed associations with hepatic encephalopathy.
Benedict Kinny-Köster +6 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Convenient Synthesis of Amino Acid Methyl Esters
Molecules, 2008 A series of amino acid methyl ester hydrochlorides were prepared in good toexcellent yields by the room temperature reaction of amino acids with methanol in thepresence of trimethylchlorosilane. This method is not only compatible with natural aminoacids,
Yaowu Sha, Jiabo Li
doaj +1 more source
Molecules, 2023 Fe (II)-and 2-ketoglutarate-dependent dioxygenases (Fe (II)/α-KG DOs) have been applied to catalyze hydroxylation of amino acids. However, the Fe (II)/α-KG DOs that have been developed and characterized are not sufficient.
Jianhong An, Jiaojiao Guan, Yao Nie
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
PLoS Pathogens, 2019 Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their host cells, either through direct uptake or degradation of host proteins. Here, we describe a family of plasma membrane-localized amino acid transporters,
Kathryn E R Parker +7 more
doaj +1 more source
e-Polymers, 2022 Antimicrobial peptide (AMP) self-assembly is an effective way to synthesis antimicrobial biomaterials. In previous studies, we found PAF26 AMP (Ac-RKKWFW-NH2) and its derivative K2–F2 peptide (Ac-KKRKKWFWFF-NH2) could both self-assemble into hydrogels ...
Cao Fengyi +5 more
doaj +1 more source
Structure and function of the aromatic amino acid hydroxylases [PDF]
Biochemical Journal, 1995 INTRODUCTION The three aromatic amino acid hydroxylases, phenylalanine hydroxylase (PheOH; EC 1.14.16.1), tyrosine hydroxylase (TyrOH; EC 1.14.16.2) and tryptophan hydroxylase (TrpOH; EC 1.14.16.4), constitute a family of enzymes that share many physical, structural and catalytic properties.
S E, Hufton, I G, Jennings, R G, Cotton
openaire +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source