Results 41 to 50 of about 597,754 (265)
Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis [PDF]
, 2020 Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented.
Pistritto, Vincent A. +2 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Regioselective Tele‐Substitution of Aroyl Chlorides via Activation by an Al/P Frustrated Lewis Pair
ChemistryEuropeThe development of tele‐substitution reactions is significant in organic synthesis. However, most reported tele‐substitutions have been limited to nucleophilic aromatic substitution.
Hirotaka Okamoto +2 more
doaj +1 more source
4,4′-(((Perfluoropropane-2,2-diyl)bis(4,1-phenylene))bis(oxy))-bis(2,3,5,6-tetrafluoropyridine)
Molbank, 2023 The title compound was synthesized in near-quantitative yield using nucleophilic aromatic substitution of 4,4′-(hexafluoroisopropylidene)diphenol (BPAF) with perfluoropyridine (PFP). The purity and structure were determined by NMR (1H, 13C, 19F), GC–EIMS,
Katelyn D. Thompson +3 more
doaj +1 more source
Some studies of the reactions of carbon nucleophiles with aromatic nitro compounds [PDF]
, 1996 Some reactions of aromatic nitro-compounds with carbon nucleophiles have been investigated. The techniques used include NMR spectroscopy, UV-visible spectroscopy and stopped-flow spectrophotometry.
Duffield, Gaynor Louise
core
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Identification and removal of a cryptic impurity in pomalidomide-PEG based PROTAC
Beilstein Journal of Organic ChemistryChemically induced dimerization is a powerful tool for studying protein function, wherein the IMiD (the “immunomodulatory drug”) class of PROTAC molecules with a PEG linker is frequently used to promote targeted protein degradation. The standard protocol
Bingnan Wang, Yong Lu, Chuo Chen
doaj +1 more source
Reaction-Based Amine and Alcohol Gases Detection with Triazine Ionic Liquid Materials
Molecules, 2019 We demonstrated in this work the use of affinity ionic liquids, AIL 1 and AIL 2, for chemoselective detection of amine and alcohol gases on a quartz crystal microbalance (QCM). These detections of gaseous amines and alcohols were achieved by nucleophilic
Hsin-Yi Li, Yen-Ho Chu
doaj +1 more source
Advanced Functional Materials, EarlyView.Sulfur fluoride exchange (SuFEx) is a powerful click platform, yet water‐compatible multifunctional linchpins remain elusive. Here, we report decagram‐scalable diazonium linchpins that enable rapid Pd‐catalyzed diversification and direct, catalyst‐free on‐DNA ligation in aqueous media.
Seok Ju Hong +5 more
wiley +1 more source
Synthesis of Polynitroxides Based on Nucleophilic Aromatic Substitution
, 2016 The scope and limitations of the synthesis of polynitroxides by nucleophilic substitution of electron-deficient fluorinated aromatic compounds are described. The method provides a facile route to the formation of polynitroxides exhibiting strong electron
Olaf Zeika (1273029) +6 more
core +2 more sources