Results 21 to 30 of about 699,324 (261)
A generally applicable quantitative reactivity model for nucleophilic aromatic substitution built from simple descriptors [PDF]
, 2022 We report a multivariate linear regression model able to make accurate predictions for the rate and regioselectivity of nucleophilic aromatic substitution (SNAr) reactions based on the electrophile structure.
Jingru, Lu, Irina, Paci, David, Leitch
core +2 more sources
Synthesis and nucleophilic aromatic substitution of 3-fluoro-5-nitro-1-(pentafluorosulfanyl)benzene
Beilstein Journal of Organic Chemistry, 2016 3-Fluoro-5-nitro-1-(pentafluorosulfanyl)benzene was prepared by three different ways: as a byproduct of direct fluorination of 1,2-bis(3-nitrophenyl)disulfane, by direct fluorination of 4-nitro-1-(pentafluorosulfanyl)benzene, and by fluorodenitration of ...
Javier Ajenjo +3 more
doaj +1 more source
Molecules, 2005 An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir ...
H.-G. Schmalz, A. Lanver
doaj +1 more source
Unravelling nucleophilic aromatic substitution pathways with bimetallic nucleophiles [PDF]
Chemical Communications, 2019 Reaction of nucleophiles containing polar (Fe–Mg) and apolar (Mg–Mg) bonds with 2-(pentafluorophenyl)pyridine are calculated to proceed by stepwise and concerted S N Ar pathways respectively.
Martí Garçon +3 more
openaire +4 more sources
Cation Radical Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis [PDF]
, 2017 Nucleophilic aromatic substitution (SNAr) is a direct method for arene functionalization; however, it can be hampered by low reactivity of arene substrates and their availability.
Tay, Nicholas E. S., Nicewicz, David A.
core +1 more source
Allylic cross-coupling using aromatic aldehydes as α-alkoxyalkyl anions
Beilstein Journal of Organic Chemistry, 2020 The allylic cross-coupling using aromatic aldehydes as α-alkoxyalkyl anions is described. The synergistic palladium/copper-catalyzed reaction of aromatic aldehydes, allylic carbonates, and a silylboronate produces the corresponding homoallylic alcohol ...
Akihiro Yuasa +2 more
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, 2021 Arylthiophene derivatives are potential components of functional materials, including organic electronics. Herein, we describe a nucleophilic aromatic substitution reaction of polyfluoroarenes using silylthiophenes as nucleophiles in the presence of a ...
Yoneda, Yuna +6 more
core +1 more source
Molecules, 2020 In this study, we present a complete description of the addition of a model nucleophile to the nitroaromatic ring in positions occupied either by hydrogen (the first step of the SNAr-H reaction) or a leaving group (SNAr-X reaction) using theoretical ...
Kacper Błaziak +2 more
doaj +1 more source
Frontiers in Chemistry, 2018 Nucleophilic aromatic substitution reactions of 4-chloroquinazoline toward aniline and hydrazine were used as a model system to experimentally show that a substrate bearing heteroatoms on the aromatic ring as substituent is able to establish ...
Bruno Sánchez +4 more
doaj +1 more source
Frontiers in Chemistry, 2021 This work presents the first transition metal-free synthesis of oxygen-linked aromatic polymers by integrating iterative exponential polymer growth (IEG) with nucleophilic aromatic substitution (SNAr) reactions.
Tyler J. Jaynes +10 more
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