Concerted Nucleophilic Aromatic Substitution Reactions [PDF]
Angewandte Chemie - International Edition, 2019 AbstractRecent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cSNAr) rather than classical, two‐step, SNAr mechanisms. Whereas traditional SNAr reactions require substantial activation of the aromatic ring by electron‐withdrawing ...
Darren Poole +2 more
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Nucleophilic Aromatic Substitution of Polyfluoroarene to Access Highly Functionalized 10-Phenylphenothiazine Derivatives [PDF]
Molecules, 2021 Nucleophilic aromatic substitution (SNAr) reactions can provide metal-free access to synthesize monosubstituted aromatic compounds. We developed efficient SNAr conditions for p-selective substitution of polyfluoroarenes with phenothiazine in the presence
Kotaro Kikushima +3 more
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A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles [PDF]
Molecules, 2018 A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as ...
Joana F. Campos +3 more
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Dynamic Nucleophilic Aromatic Substitution of Tetrazines. [PDF]
Angew Chem Int Ed Engl, 2021 AbstractA dynamic nucleophilic aromatic substitution of tetrazines (SNTz) is presented herein. It combines all the advantages of dynamic covalent chemistry with the versatility of the tetrazine moiety. Indeed, libraries of compounds or sophisticated molecular structures can be easily obtained, which are susceptible to post‐functionalization by inverse ...
Santos T +6 more
europepmc +7 more sources
Tuning Covalent Organic Frameworks via Nucleophilic Aromatic Substitution [PDF]
Small ScienceA family of covalent organic frameworks (COFs) with tuned properties has been prepared through nucleophilic aromatic substitution (SNAr) from a fluorinated imine‐linked COF (COF‐F).
Óscar González‐Rosell +8 more
doaj +2 more sources
Iterative Exponential Growth of Oxygen-Linked Aromatic Polymers Driven by Nucleophilic Aromatic Substitution Reactions [PDF]
Frontiers in Chemistry, 2021 This work presents the first transition metal-free synthesis of oxygen-linked aromatic polymers by integrating iterative exponential polymer growth (IEG) with nucleophilic aromatic substitution (SNAr) reactions.
Tyler J. Jaynes +10 more
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Synthesis and nucleophilic aromatic substitution of 3-fluoro-5-nitro-1-(pentafluorosulfanyl)benzene [PDF]
Beilstein Journal of Organic Chemistry, 2016 3-Fluoro-5-nitro-1-(pentafluorosulfanyl)benzene was prepared by three different ways: as a byproduct of direct fluorination of 1,2-bis(3-nitrophenyl)disulfane, by direct fluorination of 4-nitro-1-(pentafluorosulfanyl)benzene, and by fluorodenitration of ...
Javier Ajenjo +3 more
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A mechanistic continuum of nucleophilic aromatic substitution reactions with azole nucleophiles. [PDF]
Chem SciNucleophilic aromatic substitution reactions between indoles and aryl fluorides proceed by a general-base-catalyzed borderline mechanism and appear to lie on a mechanistic continuum.
Toll HW +8 more
europepmc +3 more sources
A new platform for the synthesis of diketopyrrolopyrrole derivatives via nucleophilic aromatic substitution reactions [PDF]
Beilstein Journal of Organic ChemistryDiketopyrrolopyrroles (DPPs) are a versatile group of dyes and pigments with valuable optoelectronic properties. In this work we report the synthesis of highly fluorescent DPP derivatives through straightforward nucleophilic aromatic substitution ...
Vitor A. S. Almodovar, Augusto C. Tomé
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On the Frontier Between Nucleophilic Aromatic Substitution and Catalysis [PDF]
Chemistry - A European Journal, 2014 AbstractA study on the arylation of heteroatom nucleophiles by using activated haloarenes, with or without metal catalysts, is reported. A discussion concerning the involvement of traces of metals is presented, supported by an unexpected ''ligand'' effect in the absence of added metal catalysts.
Thierry Ollevier, Marc Taillefer
exaly +3 more sources