Results 1 to 10 of about 699,324 (261)
Transetherification of 2,4-dimethoxynitrobenzene by aromatic nucleophilic substitution. [PDF]
PLoS ONE, 2017 In view of the few reports concerning aromatic nucleophilic substitution reactions featuring an alkoxy group as a leaving group, the aromatic nucleophilic substitution of 2,4-dimethoxynitrobenzene was investigated with a bulky t-butoxide nucleophile ...
Jiho Song +7 more
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Concerted Nucleophilic Aromatic Substitution Reactions [PDF]
Angewandte Chemie - International Edition, 2019 AbstractRecent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cSNAr) rather than classical, two‐step, SNAr mechanisms. Whereas traditional SNAr reactions require substantial activation of the aromatic ring by electron‐withdrawing ...
Darren L Poole +2 more
exaly +11 more sources
Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution [PDF]
Journal of the Serbian Chemical Society, 2016 A novel and efficient route has been developed to afford 5H-dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-di-ylbis(4-chloropyridine).
Božinović Nina +2 more
doaj +4 more sources
Molecules, 2021 Nucleophilic aromatic substitution (SNAr) reactions can provide metal-free access to synthesize monosubstituted aromatic compounds. We developed efficient SNAr conditions for p-selective substitution of polyfluoroarenes with phenothiazine in the presence
Kotaro Kikushima +3 more
doaj +3 more sources
Molecules, 2006 The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by fluoride anion via nucleophilic aromatic substitution to give the 3-fluoro- pyridine-4-carboxylate 2.
Anne Fiksdahl, Freddy Tjosaas
doaj +3 more sources
Molecules, 2018 A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as ...
Joana F. Campos +3 more
doaj +3 more sources
Concerted nucleophilic aromatic substitutions [PDF]
Nature Chemistry, 2018 Nucleophilic aromatic substitution (SNAr) is one of the most widely applied reaction classes in pharmaceutical and chemical research, providing a broadly useful platform for the modification of aromatic ring scaffolds. The generally accepted mechanism for SNAr reactions involves a two-step addition-elimination sequence via a discrete, non-aromatic ...
Eugene E. Kwan +3 more
openaire +4 more sources
Molbank, 2021 Here we describe the preparation of 2-(4-((1H-benzo[d]imidazol-2-yl)thio)-benzylidene)-hydrazine-1-carbothioamide in two steps. In the first step, 1,3-dihydro-2H-1,3-benzimidazole-2-thione was reacted with 4-fluorobenzaldehyde in DMSO to get 4-[(1H ...
Mustafa Turki Ubeid +2 more
doaj +1 more source
Dynamic Nucleophilic Aromatic Substitution of Tetrazines [PDF]
Angewandte Chemie International Edition, 2021 AbstractA dynamic nucleophilic aromatic substitution of tetrazines (SNTz) is presented herein. It combines all the advantages of dynamic covalent chemistry with the versatility of the tetrazine moiety. Indeed, libraries of compounds or sophisticated molecular structures can be easily obtained, which are susceptible to post‐functionalization by inverse ...
Tanausú Santos +6 more
openaire +5 more sources
Perfluoropyridine: Discovery, Chemistry, and Applications in Polymers and Material Science
Molecules, 2022 Perfluoropyridine (PFPy) is an organofluorine compound that has been employed for a variety of applications, from straightforward chemical synthesis to more advanced functions, such as fluorinated networks and polymers. This can be directly attributed to
Ritesh Gautam +4 more
doaj +1 more source