Results 11 to 20 of about 597,754 (265)

Preparation of Indolenines via Nucleophilic Aromatic Substitution [PDF]

Organic Letters, 2019
An unusual aromatic substitution to access indolenines is described. 2-(2-Methoxyphenyl)acetonitrile derivatives are reacted with various alkyl and aryl Li reagents to furnish the corresponding indolenine products, constituents of natural products, and cyanine dyes such as indocyanine green.
Huber, Florian, Roesslein, Joel, Gademann, Karl   +2 more
core   +7 more sources

Application Progress of N-Heterocyclic Carbene-mediated Concerted Nucleophilic Aromatic Substitution in 18F Labeling Reaction [PDF]

Journal of Isotopes
Concerted nucleophilic aromatic (CSNAr) substitution reactions play an important role in nuclear chemistry synthesis, and are now used to develop positron radiotracers.
WANG Hui1, SHAN Chongwei1, HE Yulin2
doaj   +2 more sources

Predicting Regioselectivity in Nucleophilic Aromatic Substitution

The Journal of Organic Chemistry, 2012
We have investigated practical and computationally efficient methods for the quantitative prediction of regioisomer distribution in kinetically controlled nucleophilic aromatic substitution reactions. One of the methods is based on calculating the relative stabilities of the isomeric σ-complex intermediates using DFT. We show that predictions from this
Magnus, Liljenberg, Tore, Brinck, Björn, Herschend, Tobias, Rein, Simone, Tomasi, Mats, Svensson   +5 more
openaire   +3 more sources

Concerted nucleophilic aromatic substitutions [PDF]

Nature Chemistry, 2018
Nucleophilic aromatic substitution (SNAr) is one of the most widely applied reaction classes in pharmaceutical and chemical research, providing a broadly useful platform for the modification of aromatic ring scaffolds. The generally accepted mechanism for SNAr reactions involves a two-step addition-elimination sequence via a discrete, non-aromatic ...
Eugene E. Kwan, Yuwen Zeng, Harrison A. Besser, Eric N. Jacobsen   +3 more
openaire   +4 more sources

Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen [PDF]

, 2022
An open-air method for the transition metal-free direct amination of nitro(hetero)arenes by anilines is disclosed. In this methodology, an aromatic C-H bond is substituted via oxidative nucleophilic aromatic substitution of hydrogen (ONSH).
Amy, Sarjeant, Bruce A., Ellsworth, Merrill L., Davies, Antonio, Ramirez, Darpandeep, Aulakh, Sarah C., Traeger, Nina, Suss, Alicia, Regueiro-Ren, Michael D., Mandler, Christopher A., Farley, Yeheng, Zhu   +10 more
core   +2 more sources

Dynamic Nucleophilic Aromatic Substitution of Tetrazines [PDF]

Angewandte Chemie International Edition, 2021
AbstractA dynamic nucleophilic aromatic substitution of tetrazines (SNTz) is presented herein. It combines all the advantages of dynamic covalent chemistry with the versatility of the tetrazine moiety. Indeed, libraries of compounds or sophisticated molecular structures can be easily obtained, which are susceptible to post‐functionalization by inverse ...
Tanausú Santos, David S. Rivero, Yaiza Pérez‐Pérez, Endika Martín‐Encinas, Jorge Pasán, Antonio Hernández Daranas, Romen Carrillo   +6 more
openaire   +5 more sources

Cation Radical-Accelerated Nucleophilic Aromatic Substitution for Amination of Alkoxyarenes [PDF]

, 2020
Nucleophilic aromatic substitution (SNAr) is a common method for arene functionalization; however, reactions of this type are typically limited to electron-deficient aromatic halides.
Nicewicz, David A., Venditto, Nicholas J.   +1 more
core   +1 more source

A generally applicable quantitative reactivity model for nucleophilic aromatic substitution built from simple descriptors [PDF]

, 2022
We report a multivariate linear regression model able to make accurate predictions for the rate and regioselectivity of nucleophilic aromatic substitution (SNAr) reactions based on the electrophile structure.
Jingru, Lu, Irina, Paci, David, Leitch
core   +2 more sources

Transition-Metal-Mediated Nucleophilic Aromatic Substitution with Acids [PDF]

, 2016
Transition-metal-mediated nucleophilic aromatic substitution (S_NAr) reactions prefer that a suitably strong nucleophile be in an aprotic medium. Usually, using protic nucleophile/medium requires high reaction temperatures (>180 °C) to overcome the ...
Nielsen, Robert J., Johnson, Samantha I., O’Reilly, Matthew E., Gunnoe, T. Brent, Goddard, William A., III   +4 more
core   +2 more sources

Preparação de N-alquil derivados do 1-bromo-2,4-dinitrobenzeno e do 1-cloro-2-nitrobenzeno: Uma alternativa às aulas práticas de substituição nucleofílica aromática Preparation of N-alkyl derivatives of 1-bromo-2,4-dinitrobenzene and 1-chloro-2-nitrobenzene: An alternative to nucleophilic aromatic substitution practices

Química Nova, 2008
Preparation of the title compounds are described as an alternative nucleophilic aromatic substitution for practices in the graduate laboratory. The low toxicity and disponibility of the reagents make a suitable procedure approach to experiments regarding
Ayres Guimarães Dias, Felipe Martins Alves Pereira, Renato de Oliveira Soares   +2 more
doaj   +1 more source