Results 11 to 20 of about 699,324 (261)

Preparation of Indolenines via Nucleophilic Aromatic Substitution [PDF]

Organic Letters, 2019
An unusual aromatic substitution to access indolenines is described. 2-(2-Methoxyphenyl)acetonitrile derivatives are reacted with various alkyl and aryl Li reagents to furnish the corresponding indolenine products, constituents of natural products, and cyanine dyes such as indocyanine green.
Huber, Florian, Roesslein, Joel, Gademann, Karl   +2 more
core   +7 more sources

Application Progress of N-Heterocyclic Carbene-mediated Concerted Nucleophilic Aromatic Substitution in 18F Labeling Reaction [PDF]

Journal of Isotopes
Concerted nucleophilic aromatic (CSNAr) substitution reactions play an important role in nuclear chemistry synthesis, and are now used to develop positron radiotracers.
WANG Hui1, SHAN Chongwei1, HE Yulin2
doaj   +2 more sources

Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen [PDF]

, 2022
An open-air method for the transition metal-free direct amination of nitro(hetero)arenes by anilines is disclosed. In this methodology, an aromatic C-H bond is substituted via oxidative nucleophilic aromatic substitution of hydrogen (ONSH).
Amy, Sarjeant, Bruce A., Ellsworth, Merrill L., Davies, Antonio, Ramirez, Darpandeep, Aulakh, Sarah C., Traeger, Nina, Suss, Alicia, Regueiro-Ren, Michael D., Mandler, Christopher A., Farley, Yeheng, Zhu   +10 more
core   +2 more sources

Cation Radical-Accelerated Nucleophilic Aromatic Substitution for Amination of Alkoxyarenes [PDF]

, 2020
Nucleophilic aromatic substitution (SNAr) is a common method for arene functionalization; however, reactions of this type are typically limited to electron-deficient aromatic halides.
Nicewicz, David A., Venditto, Nicholas J.   +1 more
core   +1 more source

New opportunities for the synthesis of quinoxaline derivatives

Chimica Techno Acta, 2019
Convenient methods for the synthesis of quinoxaline derivatives with the use of nucleophilic aromatic substitution of hydrogen in heteroaromatic part of molecule in conditions of the acid catalysis were elaborated.
Olga S. Koptyaeva, Yuriy A. Azev, Yuriy M. Shafran, Tatyana A. Pospelova, Oleg N. Chupakhin   +4 more
doaj   +1 more source

1-(2,5-Dimethoxy-4-nitrophenyl)piperidine

Molbank, 2023
Treatment of the non-purified mixture of dinitro isomers obtained from the nitration of 1,4-dimethoxybenzene with piperidine led to the isolation of novel but minor adduct, 1-(2,5-dimethoxy-4-nitrophenyl)piperidine (2b) in 15% yield.
Tanjia M. Syeda, Muadh R. Al-Shaidi, Ibtihal Basri, Mahboub Merzouk, Fawaz Aldabbagh   +4 more
doaj   +1 more source

Transition-Metal-Mediated Nucleophilic Aromatic Substitution with Acids [PDF]

, 2016
Transition-metal-mediated nucleophilic aromatic substitution (S_NAr) reactions prefer that a suitably strong nucleophile be in an aprotic medium. Usually, using protic nucleophile/medium requires high reaction temperatures (>180 °C) to overcome the ...
Nielsen, Robert J., Johnson, Samantha I., O’Reilly, Matthew E., Gunnoe, T. Brent, Goddard, William A., III   +4 more
core   +2 more sources

Mechanisms of Nucleophilic Aromatic and Hetero-aromatic Substitution. Recent Developments

CHIMIA, 1980
There are now at least five well defined mechanisms of nucleophilic aromatic and heteroaromatic substitution. Three of them, the SNAr, the benzyne and the SN1 mechanism, have been known for a long time, whereas the SRN1and the SN (ANRORC) mechanisms are
Claude F. Bernasconi
doaj   +1 more source

Preparação de N-alquil derivados do 1-bromo-2,4-dinitrobenzeno e do 1-cloro-2-nitrobenzeno: Uma alternativa às aulas práticas de substituição nucleofílica aromática Preparation of N-alkyl derivatives of 1-bromo-2,4-dinitrobenzene and 1-chloro-2-nitrobenzene: An alternative to nucleophilic aromatic substitution practices

Química Nova, 2008
Preparation of the title compounds are described as an alternative nucleophilic aromatic substitution for practices in the graduate laboratory. The low toxicity and disponibility of the reagents make a suitable procedure approach to experiments regarding
Ayres Guimarães Dias, Felipe Martins Alves Pereira, Renato de Oliveira Soares   +2 more
doaj   +1 more source

Synthesis of Azuleno[2,1-b]quinolones and Quinolines via Brønsted Acid-Catalyzed Cyclization of 2-Arylaminoazulenes

Molecules, 2023
Quinolone and quinoline derivatives are frequently found as substructures in pharmaceutically active compounds. In this paper, we describe a procedure for the synthesis of azuleno[2,1-b]quinolones and quinolines from 2-arylaminoazulene derivatives, which
Taku Shoji, Mutsumi Takeuchi, Mayumi Uda, Yukino Ariga, Akari Yamazaki, Ryuta Sekiguchi, Shunji Ito   +6 more
doaj   +1 more source