Transetherification of 2,4-dimethoxynitrobenzene by aromatic nucleophilic substitution. [PDF]
PLoS ONE, 2017 In view of the few reports concerning aromatic nucleophilic substitution reactions featuring an alkoxy group as a leaving group, the aromatic nucleophilic substitution of 2,4-dimethoxynitrobenzene was investigated with a bulky t-butoxide nucleophile ...
Jiho Song +7 more
doaj +2 more sources
Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution [PDF]
Journal of the Serbian Chemical Society, 2016 A novel and efficient route has been developed to afford 5H-dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-di-ylbis(4-chloropyridine).
Božinović Nina +2 more
doaj +4 more sources
Preparation of Indolenines via Nucleophilic Aromatic Substitution [PDF]
Organic Letters, 2019 An unusual aromatic substitution to access indolenines is described. 2-(2-Methoxyphenyl)acetonitrile derivatives are reacted with various alkyl and aryl Li reagents to furnish the corresponding indolenine products, constituents of natural products, and cyanine dyes such as indocyanine green.
Huber, Florian +2 more
core +7 more sources
Application Progress of N-Heterocyclic Carbene-mediated Concerted Nucleophilic Aromatic Substitution in 18F Labeling Reaction [PDF]
Journal of IsotopesConcerted nucleophilic aromatic (CSNAr) substitution reactions play an important role in nuclear chemistry synthesis, and are now used to develop positron radiotracers.
WANG Hui1, SHAN Chongwei1, HE Yulin2
doaj +2 more sources
Cation Radical-Accelerated Nucleophilic Aromatic Substitution for Amination of Alkoxyarenes. [PDF]
Org Lett, 2020 Nucleophilic aromatic substitution (SNAr) is a common method for arene functionalization; however, reactions of this type are typically limited to electron-deficient aromatic halides.
Venditto NJ, Nicewicz DA.
europepmc +2 more sources
Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis. [PDF]
J Am Chem Soc, 2020 Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented.
Pistritto VA +2 more
europepmc +2 more sources
Concerted nucleophilic aromatic substitutions [PDF]
Nature Chemistry, 2018 Nucleophilic aromatic substitution (SNAr) is one of the most widely applied reaction classes in pharmaceutical and chemical research, providing a broadly useful platform for the modification of aromatic ring scaffolds. The generally accepted mechanism for SNAr reactions involves a two-step addition-elimination sequence via a discrete, non-aromatic ...
Eugene E. Kwan +3 more
openaire +4 more sources
Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen [PDF]
, 2022 An open-air method for the transition metal-free direct amination of nitro(hetero)arenes by anilines is disclosed. In this methodology, an aromatic C-H bond is substituted via oxidative nucleophilic aromatic substitution of hydrogen (ONSH).
Amy, Sarjeant +10 more
core +2 more sources
Molbank, 2021 Here we describe the preparation of 2-(4-((1H-benzo[d]imidazol-2-yl)thio)-benzylidene)-hydrazine-1-carbothioamide in two steps. In the first step, 1,3-dihydro-2H-1,3-benzimidazole-2-thione was reacted with 4-fluorobenzaldehyde in DMSO to get 4-[(1H ...
Mustafa Turki Ubeid +2 more
doaj +1 more source
Ruthenium-mediated nucleophilic aromatic substitution of hydrogen in benzene. [PDF]
Chem SciThe direct functionalization of unactivated hydrocarbons remains a significant challenge in modern chemistry. In this study, we demonstrate that a simple ruthenium complex featuring a chelating tBuPN ligand can mediate the nucleophilic aromatic ...
Melnikov S +6 more
europepmc +3 more sources