Results 11 to 20 of about 23,008 (222)

Dynamic Nucleophilic Aromatic Substitution of Tetrazines. [PDF]

Angew Chem Int Ed Engl, 2021
AbstractA dynamic nucleophilic aromatic substitution of tetrazines (SNTz) is presented herein. It combines all the advantages of dynamic covalent chemistry with the versatility of the tetrazine moiety. Indeed, libraries of compounds or sophisticated molecular structures can be easily obtained, which are susceptible to post‐functionalization by inverse ...
Santos T, Rivero DS, Pérez-Pérez Y, Martín-Encinas E, Pasán J, Daranas AH, Carrillo R.   +6 more
europepmc   +7 more sources

Concerted nucleophilic aromatic substitutions [PDF]

Nature Chemistry, 2018
Nucleophilic aromatic substitution (SNAr) is one of the most widely applied reaction classes in pharmaceutical and chemical research, providing a broadly useful platform for the modification of aromatic ring scaffolds. The generally accepted mechanism for SNAr reactions involves a two-step addition-elimination sequence via a discrete, non-aromatic ...
Eugene E. Kwan, Yuwen Zeng, Harrison A. Besser, Eric N. Jacobsen   +3 more
openaire   +4 more sources

Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution [PDF]

Journal of the Serbian Chemical Society, 2016
A novel and efficient route has been developed to afford 5H-dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-di-ylbis(4-chloropyridine).
Božinović Nina, Šolaja Bogdan A., Opsenica Igor M.   +2 more
doaj   +1 more source

Perfluoropyridine: Discovery, Chemistry, and Applications in Polymers and Material Science

Molecules, 2022
Perfluoropyridine (PFPy) is an organofluorine compound that has been employed for a variety of applications, from straightforward chemical synthesis to more advanced functions, such as fluorinated networks and polymers. This can be directly attributed to
Ritesh Gautam, Ian Geniza, Scott T. Iacono, Chadron M. Friesen, Abby R. Jennings   +4 more
doaj   +1 more source

New opportunities for the synthesis of quinoxaline derivatives

Chimica Techno Acta, 2019
Convenient methods for the synthesis of quinoxaline derivatives with the use of nucleophilic aromatic substitution of hydrogen in heteroaromatic part of molecule in conditions of the acid catalysis were elaborated.
Olga S. Koptyaeva, Yuriy A. Azev, Yuriy M. Shafran, Tatyana A. Pospelova, Oleg N. Chupakhin   +4 more
doaj   +1 more source

1-(2,5-Dimethoxy-4-nitrophenyl)piperidine

Molbank, 2023
Treatment of the non-purified mixture of dinitro isomers obtained from the nitration of 1,4-dimethoxybenzene with piperidine led to the isolation of novel but minor adduct, 1-(2,5-dimethoxy-4-nitrophenyl)piperidine (2b) in 15% yield.
Tanjia M. Syeda, Muadh R. Al-Shaidi, Ibtihal Basri, Mahboub Merzouk, Fawaz Aldabbagh   +4 more
doaj   +1 more source

Mechanisms of Nucleophilic Aromatic and Hetero-aromatic Substitution. Recent Developments

CHIMIA, 1980
There are now at least five well defined mechanisms of nucleophilic aromatic and heteroaromatic substitution. Three of them, the SNAr, the benzyne and the SN1 mechanism, have been known for a long time, whereas the SRN1and the SN (ANRORC) mechanisms are
Claude F. Bernasconi
doaj   +1 more source

Preparação de N-alquil derivados do 1-bromo-2,4-dinitrobenzeno e do 1-cloro-2-nitrobenzeno: Uma alternativa às aulas práticas de substituição nucleofílica aromática Preparation of N-alkyl derivatives of 1-bromo-2,4-dinitrobenzene and 1-chloro-2-nitrobenzene: An alternative to nucleophilic aromatic substitution practices

Química Nova, 2008
Preparation of the title compounds are described as an alternative nucleophilic aromatic substitution for practices in the graduate laboratory. The low toxicity and disponibility of the reagents make a suitable procedure approach to experiments regarding
Ayres Guimarães Dias, Felipe Martins Alves Pereira, Renato de Oliveira Soares   +2 more
doaj   +1 more source

Synthesis of Azuleno[2,1-b]quinolones and Quinolines via Brønsted Acid-Catalyzed Cyclization of 2-Arylaminoazulenes

Molecules, 2023
Quinolone and quinoline derivatives are frequently found as substructures in pharmaceutically active compounds. In this paper, we describe a procedure for the synthesis of azuleno[2,1-b]quinolones and quinolines from 2-arylaminoazulene derivatives, which
Taku Shoji, Mutsumi Takeuchi, Mayumi Uda, Yukino Ariga, Akari Yamazaki, Ryuta Sekiguchi, Shunji Ito   +6 more
doaj   +1 more source

A mechanistic continuum of nucleophilic aromatic substitution reactions with azole nucleophiles. [PDF]

Chem Sci
Nucleophilic aromatic substitution reactions between indoles and aryl fluorides proceed by a general-base-catalyzed borderline mechanism and appear to lie on a mechanistic continuum.
Toll HW, Zhang X, Gao T, Dal Poggetto G, Reibarkh M, Lee JJ, Yang KJ, Kwan EE, Turek AK.   +8 more
europepmc   +3 more sources