Molbank, 2023 A monosubstituted benzene-1,2-diamine building block, N1-(3,5-bis(trifluoromethyl)benzyl)benzene-1,2-diamine, was prepared in two steps from commercially available 3,5-bis(trifluoromethyl)benzylamine and 1-fluoro-2-nitrobenzene, while the use of 3,5-bis ...
Luka Ciber +5 more
doaj +1 more source
Specific nucleophile–electrophile interactions in nucleophilic aromatic substitutions
Organic & Biomolecular Chemistry, 2013 We herein report results obtained from an integrated experimental and theoretical study on aromatic nucleophilic substitution (S(N)Ar) reactions of a series of amines towards 1-fluoro-2,4-dinitrobenzene in water. Specific nucleophile-electrophile interactions in the title reactions have been kinetically evaluated.
Ormazábal Toledo, R. +3 more
openaire +7 more sources
Nucleophilic substitution reactions of some polyhalogenated compounds [PDF]
, 1987 Rate measurements for the reactions of a series of polyfluoro - and polychloro - pyridines with aniline and ammonia in 60/40 dioxan/water at 25ºC has shown that chlorine, when ortho and para to the position of attack, is activating with respect to ...
Martin, Peter Arnold
core
Substituição nucleofílica aromática em 1,2-dicloro-4,5-dinitrobenzeno com aminas [PDF]
, 2006 TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.O 1,2-dicloro-4,5-dinitrobenzeno, DCDNB, reage com aminas primárias em condições de temperatura e pressão ambientes, formando produtos ...
Ricardo, Juan
core
Regioselective Tele‐Substitution of Aroyl Chlorides via Activation by an Al/P Frustrated Lewis Pair
ChemistryEuropeThe development of tele‐substitution reactions is significant in organic synthesis. However, most reported tele‐substitutions have been limited to nucleophilic aromatic substitution.
Hirotaka Okamoto +2 more
doaj +1 more source
4,4′-(((Perfluoropropane-2,2-diyl)bis(4,1-phenylene))bis(oxy))-bis(2,3,5,6-tetrafluoropyridine)
Molbank, 2023 The title compound was synthesized in near-quantitative yield using nucleophilic aromatic substitution of 4,4′-(hexafluoroisopropylidene)diphenol (BPAF) with perfluoropyridine (PFP). The purity and structure were determined by NMR (1H, 13C, 19F), GC–EIMS,
Katelyn D. Thompson +3 more
doaj +1 more source
Some studies of the reactions of carbon nucleophiles with aromatic nitro compounds [PDF]
, 1996 Some reactions of aromatic nitro-compounds with carbon nucleophiles have been investigated. The techniques used include NMR spectroscopy, UV-visible spectroscopy and stopped-flow spectrophotometry.
Duffield, Gaynor Louise
core
Identification and removal of a cryptic impurity in pomalidomide-PEG based PROTAC
Beilstein Journal of Organic ChemistryChemically induced dimerization is a powerful tool for studying protein function, wherein the IMiD (the “immunomodulatory drug”) class of PROTAC molecules with a PEG linker is frequently used to promote targeted protein degradation. The standard protocol
Bingnan Wang, Yong Lu, Chuo Chen
doaj +1 more source
Reaction-Based Amine and Alcohol Gases Detection with Triazine Ionic Liquid Materials
Molecules, 2019 We demonstrated in this work the use of affinity ionic liquids, AIL 1 and AIL 2, for chemoselective detection of amine and alcohol gases on a quartz crystal microbalance (QCM). These detections of gaseous amines and alcohols were achieved by nucleophilic
Hsin-Yi Li, Yen-Ho Chu
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Synthesis of Polynitroxides Based on Nucleophilic Aromatic Substitution
, 2016 The scope and limitations of the synthesis of polynitroxides by nucleophilic substitution of electron-deficient fluorinated aromatic compounds are described. The method provides a facile route to the formation of polynitroxides exhibiting strong electron
Olaf Zeika (1273029) +6 more
core +2 more sources