Results 21 to 30 of about 23,008 (222)

Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues

Molecules, 2005
An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir ...
H.-G. Schmalz, A. Lanver
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Unravelling nucleophilic aromatic substitution pathways with bimetallic nucleophiles [PDF]

Chemical Communications, 2019
Reaction of nucleophiles containing polar (Fe–Mg) and apolar (Mg–Mg) bonds with 2-(pentafluorophenyl)pyridine are calculated to proceed by stepwise and concerted S N Ar pathways respectively.
Martí Garçon, Clare Bakewell, Andrew J. P. White, Mark R. Crimmin   +3 more
openaire   +4 more sources

Allylic cross-coupling using aromatic aldehydes as α-alkoxyalkyl anions

Beilstein Journal of Organic Chemistry, 2020
The allylic cross-coupling using aromatic aldehydes as α-alkoxyalkyl anions is described. The synergistic palladium/copper-catalyzed reaction of aromatic aldehydes, allylic carbonates, and a silylboronate produces the corresponding homoallylic alcohol ...
Akihiro Yuasa, Kazunori Nagao, Hirohisa Ohmiya   +2 more
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Application Progress of N-Heterocyclic Carbene-mediated Concerted Nucleophilic Aromatic Substitution in 18F Labeling Reaction

Journal of Isotopes
Concerted nucleophilic aromatic (CSNAr) substitution reactions play an important role in nuclear chemistry synthesis, and are now used to develop positron radiotracers.
WANG Hui1, SHAN Chongwei1, HE Yulin2
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How Do Aromatic Nitro Compounds React with Nucleophiles? Theoretical Description Using Aromaticity, Nucleophilicity and Electrophilicity Indices

Molecules, 2020
In this study, we present a complete description of the addition of a model nucleophile to the nitroaromatic ring in positions occupied either by hydrogen (the first step of the SNAr-H reaction) or a leaving group (SNAr-X reaction) using theoretical ...
Kacper Błaziak, Witold Danikiewicz, Mieczysław Mąkosza   +2 more
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Activation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a SNAr Reaction

Frontiers in Chemistry, 2018
Nucleophilic aromatic substitution reactions of 4-chloroquinazoline toward aniline and hydrazine were used as a model system to experimentally show that a substrate bearing heteroatoms on the aromatic ring as substituent is able to establish ...
Bruno Sánchez, Cristian Calderón, Ricardo A. Tapia, Renato Contreras, Paola R. Campodónico   +4 more
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From porphyrin benzylphosphoramidate conjugates to the catalytic hydrogenation of 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin

Beilstein Journal of Organic Chemistry, 2014
Three new porphyrin aminoalkyl dibenzylphosphoramidates were synthesized by nucleophilic aromatic substitution of one p-fluorine atom of 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (TPPF20) by primary aminoalkyl dibenzylphosphoramidates.
Marcos C. de Souza, Leandro F. Pedrosa, Géssica S. Cazagrande, Vitor F. Ferreira, Maria G. P. M. S. Neves, José A. S. Cavaleiro   +5 more
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Crystal structure of 4-(4-methoxyphenoxy)benzaldehyde

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C14H12O3, was synthesized via the nucleophilic addition of 4-methoxyphenol to 4-fluorobenzaldehyde. The dihedral angle between the least-squares planes of the benzene rings is 71.52 (3)° and the C—O—C angle at the central O atom is ...
Andreas Schäfer, Ljuba Iovkova-Berends, Stefan Gilke, Paul Kossmann, Hans Preut, Martin Hiersemann   +5 more
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Three-Component Condensation of β-Ketonitriles, 4-Fluorobenzaldehyde, and Secondary Cyclic Amines

Reactions, 2022
A new three-component condensation of β-ketonitriles, 4-fluorobenzaldehyde, and secondary cyclic amines was developed. A possible reaction mechanism has been proposed including Knoevenagel condensation followed by aromatic nucleophilic substitution.
Dmitry V. Osipov, Kirill S. Korzhenko, Vitaly A. Osyanin   +2 more
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Synthesis of N¹-(3,5-Bis(trifluoromethyl)benzyl)benzene-1,2-diamine and N,N-Bis(2-nitrophenyl)-3,5-bis(trifluoromethyl)aniline

Molbank, 2023
A monosubstituted benzene-1,2-diamine building block, N1-(3,5-bis(trifluoromethyl)benzyl)benzene-1,2-diamine, was prepared in two steps from commercially available 3,5-bis(trifluoromethyl)benzylamine and 1-fluoro-2-nitrobenzene, while the use of 3,5-bis ...
Luka Ciber, Helena Brodnik, Franc Požgan, Jurij Svete, Bogdan Štefane, Uroš Grošelj   +5 more
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