Results 81 to 90 of about 1,071,960 (344)
Understanding Challenges to High-quality Pediatric Out-of-Hospital Cardiac Arrest Resuscitation Performance [PDF]
, 2023 Amanda O’Halloran, Akira Nishisaki
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
أصداء الثورة في الشعر السوريّ – دراسة تحليليّة
Rize İlahiyat Dergisiقامت الثورة السورية منتصف آذار 2011 بعد سلسلة من الثورات العربيّة في تونس ومصر وليبيا واليمن، وقد كان السبب الرئيس لها هو الظلم والذل والقهر والاعتقال والتعذيب الذي تعرض له الشعب السوري خلال أكثر من نصف قرن على يد السلطة الحاكمة الدكتاتورية، وقد انطلقت ...
Ahmet Onur
doaj +1 more source
Journal of Family Medicine and Primary Care, 2020 Silver diamine fluoride (SDF) has been extensively researched and proven effective for caries prevention and arrest in children. Limited studies support its effectiveness in primary dentition at 38%.
Zohra Jabin +5 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Out-of-hospital cardiac arrest: prehospital management.
The Lancet, 2018 Sudden out-of-hospital cardiac arrest is the most time-critical medical emergency. In the second paper of this Series on out-of-hospital cardiac arrest, we considered important issues in the prehospital management of cardiac arrest.
M. Ong, G. Perkins, A. Cariou
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury
Critical Care, 2013 IntroductionAcute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit.
K. Kashani +40 more
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Veterinary EvidenceIntroduction: The RECOVER guidelines (2012) on veterinary cardiopulmonary resuscitation (CPR) suggest refresher training every 3–6 months. This audit was undertaken to see if this can impact veterinary professionals’ psychomotor skills and knowledge ...
Clare Jones
doaj +1 more source