Results 41 to 50 of about 12,640 (288)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
AC Flashover Performance of 10 kV Rod-Plane Air-Gapped Arresters under Rain Conditions
Energies, 2018 According to operational experience of power systems, the outdoor insulation strength can be reduced due to the effect of rain. Till now, little work has been done to investigate the flashover performance of air gapped arresters under rain conditions ...
Jiazheng Lu +4 more
doaj +1 more source
Evaluation of the EMC environment generated by a static var compensator [PDF]
, 2009 Describes an evaluation of the EMC environment generated by a static var ...
Li, Q., Siew, W.H., Wang, W., Zhang, L.
core
Trends in Genetics, 2017 Evolution in the form of selective breeding has long been harnessed as a useful tool by humans. However, rapid evolution can also be a danger to our health and a stumbling block for biotechnology. Unwanted evolution can underlie the emergence of drug and pesticide resistance, cancer, and weeds.
James J, Bull, Jeffrey E, Barrick
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Improving safety of runway overrun through the correct numerical evaluation of rutting in Cleared and Graded Areas [PDF]
, 2014 Aircraft overrun is potentially very dangerous to human life. Statistics show that overrun is mainly due to human errors causing loss of control in wheel alignment, high approach speed, and long touchdown.
Benedetto, Andrea +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
DC‐presaturated fault current limiter for high voltage direct current transmission systems
High Voltage, 2021 The authors present a 500 kV real‐dimension DC‐presaturated fault current limiter (PFCL) with a steady‐state rated current of 2 kA for limiting large fault current of 8 kA with high rate of rise. These characteristics of the fault current can be a threat
Mohamed Eladawy +2 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source