Results 61 to 70 of about 8,973 (298)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

EVALUATION OF ENERGY STRESS ON LINE ARRESTERS [PDF]

, 2011
Line Surge Arresters (LSAs) are efficient means for the improvement of the lightning performance of transmission lines. Determination of optimal LSA number, location and rating is important for the improvement of the reliability and availability of a ...
Filipović-Grčić, B., Tokić, A., Uglešić, I., Milardić, V.   +3 more
core   +1 more source

Study on the lightning overvoltage protection of a 500 kV unified power flow controller station

The Journal of Engineering, 2018
The unified power flow controller (UPFC) is the third generation of flexible AC transmission systems. It can control the power flow and voltage of the power system quickly and flexibly that has an advantage in compensating the AC transmission system in ...
Ting Ding, Fengbo Tao, Hengxin He, Jiqun Zhong, Junjia He, Huiwen He   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Lightning Flashover Characteristic and Effective Protection Measures of 10 kV Distribution Line Network

Energies
Among various failure causes, lightning overvoltage represents the most significant threat to overhead distribution lines, which serve as critical components in power systems.
Song Zhang, Xiaobin Xiao, Lei Jia, Huaifei Chen, Lu Qu, Chakhung Yeung, Yuxuan Ding, Yaping Du   +7 more
doaj   +1 more source

Characteristics of Overvoltage Protection with Cascade Application of Surge Protective Devices in Low-Voltage AC Power Circuits

Advances in Electrical and Computer Engineering, 2015
Surge Protective Devices (SPDs) are widely used for protection of the equipment in low-voltage AC power circuits against wide variety of surges. Cascade application of SPDs starting at the service entrance of a building and downstream toward near ...
RADULOVIC, V., MUJOVIC, S., MILJANIC, Z.
doaj   +1 more source

Research on key technologies in ±1100 kV ultra-high voltage DC transmission

High Voltage, 2018
Based on completely mastering ±800 kV transmission technologies, the first ±1100 kV direct current (DC) transmission demonstration project is being constructed in China.
Zehong Liu, Fuxuan Zhang, Jun Yu, Keli Gao, Weimin Ma   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Diagnostics of middle voltage arresters [PDF]

, 2011
W pracy przedstawiono metody oceny stanu technicznego warystorowych ograniczników przepięć średniego napięcia stosowane w badaniach laboratoryjnych oraz w eksploatacji - wykonywane bez wyłączania ograniczników z sieci.
Hasse, L., Olesz, M.
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source