Results 41 to 50 of about 438,424 (336)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Desenvolvimento de subsídios para aplicação em testes de avaliação de para-raios de ZnO [PDF]

open access: yes, 2012
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Elétrica, Florianópolis, 2011Este trabalho apresenta como proposta principal verificar as influências externas, como a ...
Videira, André Gomes
core  

Arresting Evolution [PDF]

open access: yesTrends in Genetics, 2017
Evolution in the form of selective breeding has long been harnessed as a useful tool by humans. However, rapid evolution can also be a danger to our health and a stumbling block for biotechnology. Unwanted evolution can underlie the emergence of drug and pesticide resistance, cancer, and weeds.
James J, Bull, Jeffrey E, Barrick
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Polymer Surge Arresters: Degradation Versus Electrical Performance

open access: yes, 2015
This research presents the electrical performance of metal-oxide surge arresters with polymeric housing, applied on the power distribution network, as a function of the physical-chemical degradation which over the time they are exposed.
Jesus R.C.   +6 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Diagnostic of Silicon Carbide Surge Arresters using Leakage Current Measurement

open access: yes, 2011
Nowadays, the zinc oxide surge arresters (ZnO) are widely used in power systems, however, a large number of silicon carbide surge arresters (SiC) are still in service in the utilities.
Arnaldo Gakiya Kanashiro   +7 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Lightning Protection of Distribution Substations by Using Metal Oxide Gapless Surge Arresters Connected in Parallel

open access: yes, 2017
The adequate protection of the distribution transformers is a critical issue, in an effort to avoid interruption of the power supply and damages of the equipment. The installation of metal oxide gapless surge arresters at the entrance of the transformers
C. Christodoulou, V. Vita, T. Maris
semanticscholar   +1 more source

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