Results 51 to 60 of about 8,973 (298)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
DC‐presaturated fault current limiter for high voltage direct current transmission systems
High Voltage, 2021 The authors present a 500 kV real‐dimension DC‐presaturated fault current limiter (PFCL) with a steady‐state rated current of 2 kA for limiting large fault current of 8 kA with high rate of rise. These characteristics of the fault current can be a threat
Mohamed Eladawy +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Journal of Engineering, 2018 High-voltage DC arrester is one of the key equipment for overvoltage protection of ultra-high voltage DC (UHVDC) transmission system. This device plays a decisive role in the insulation level of the whole process.
Dianlang Wang +10 more
doaj +1 more source
Characteristics of lightning‐induced voltages based on experimental data
High Voltage, 2021 This paper presents an analysis of 64 lightning‐induced voltage waveforms recorded in an experimental system implemented in the campus of the University of São Paulo, Brazil.
Michele N. N. Santos, Alexandre Piantini
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Development of online monitor for substation 10 kV MOA
The Journal of Engineering, 2019 Metal oxide arresters (MOA) are widely used for over-voltage protection of power facilities in 10 kV distribution networks, and it is hard to determine the failure ones. This study presented an online monitor for 10 kV MOA used in substation.
Xinming Song +4 more
doaj +1 more source