Results 151 to 160 of about 24,311 (208)

Functional characterisation of obesity-associated MRAP2 variants on MC4R and GHSR signalling. [PDF]

open access: yesHum Mol Genet
Rodríguez Rondón AV   +9 more
europepmc   +1 more source

β-Arrestin 1 Differentially Modulates cAMP and ERK Pathways Downstream of the FSH Receptor. [PDF]

open access: yesCurr Issues Mol Biol
Park SH   +8 more
europepmc   +1 more source

Single-position ligand modifications tune CB<sub>2</sub>R activity by targeting the toggle switch. [PDF]

open access: yesChem Sci
Ganzoni RLZ   +23 more
europepmc   +1 more source
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Arrestins in Bone

2013
Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis.
Brittany N, Bohinc, Diane, Gesty-Palmer
openaire   +2 more sources

Diversity in arrestin function

Cellular and Molecular Life Sciences, 2009
The termination of heptahelical receptor signaling is a multilevel process coordinated, in large part, by members of the arrestin family of proteins. Arrestin binding to agonist-occupied receptors promotes desensitization by interrupting receptor-G protein coupling, while simultaneously recruiting machinery for receptor endocytosis, vesicular ...
Ryan T, Kendall, Louis M, Luttrell
openaire   +2 more sources

Phosphorylation-dependent conformational changes of arrestin in the rhodopsin–arrestin complex

Physical Chemistry Chemical Physics, 2020
Conformations of GPCR-bound arrestin depend on the phosphorylation patterns of the GPCR C-loop.
Dali Wang   +3 more
openaire   +2 more sources

Arrestins lie in wait

Science Signaling, 2023
Preassociation of β-arrestins with the plasma membrane facilitates their interactions with GPCRs.
openaire   +2 more sources

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