Results 161 to 170 of about 24,588 (216)

Mechanisms limiting the long-term anabolic effects of teriparatide (PTH 1-34) on bone. [PDF]

JBMR Plus
Schmal C, Wu JY, Jafari A.
europepmc   +1 more source

Cell-Type-Dependent Metabolic Compensation Preserves Photoreceptor Survival Through Pyruvate Kinase Isoform Balance. [PDF]

FASEB J
Rajala A, Trevino LJ, Black TM, Rajala RVS.   +3 more
europepmc   +1 more source

Protease-Activated Receptor-2 Promotes Metastasis: An Emerging Therapeutic Target. [PDF]

Mol Cancer Res
Strong AA, Buzza MS, Antalis TM.
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GPCR kinase 3 phosphorylates atypical chemokine receptor 4 independent of G proteins

Lamme TD, Sánchez Arroyo IB, Smit MJ, Schafer CT.   +3 more
europepmc   +1 more source

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Arrestins in Bone

2013
Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis.
Brittany N, Bohinc, Diane, Gesty-Palmer
openaire   +2 more sources

Diversity in arrestin function

Cellular and Molecular Life Sciences, 2009
The termination of heptahelical receptor signaling is a multilevel process coordinated, in large part, by members of the arrestin family of proteins. Arrestin binding to agonist-occupied receptors promotes desensitization by interrupting receptor-G protein coupling, while simultaneously recruiting machinery for receptor endocytosis, vesicular ...
Ryan T, Kendall, Louis M, Luttrell
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Phosphorylation-dependent conformational changes of arrestin in the rhodopsin–arrestin complex

Physical Chemistry Chemical Physics, 2020
Conformations of GPCR-bound arrestin depend on the phosphorylation patterns of the GPCR C-loop.
Dali Wang, Xiangdong Liu, Jianqiang Liu, Chen Song   +3 more
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Arrestins lie in wait

Science Signaling, 2023
Preassociation of β-arrestins with the plasma membrane facilitates their interactions with GPCRs.
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The Role of Arrestins in Development

2013
β-Arrestins are versatile scaffolding proteins that are involved in orchestrating a large number of signaling cascades. Because β-arrestin 1 and β-arrestin 2 are individually dispensable during development, it has long been assumed that β-arrestins do not play an important role during embryogenesis.
Melanie, Philipp, Tama, Evron, Marc G, Caron   +2 more
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Arrestins in the Cardiovascular System

2013
Of the four mammalian arrestins, only the β-arrestins (βarrs; Arrestin2 and -3) are expressed throughout the cardiovascular system, where they regulate, as either desensitizers/internalizers or signal transducers, several G-protein-coupled receptors (GPCRs) critical for cardiovascular homeostasis.
Anastasios, Lymperopoulos, Ashley, Bathgate   +1 more
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