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Characterization of arrestin expression and function
2002Publisher Summary Arrestins mediate the desensitization and trafficking of numerous G protein coupled receptors (GPCRs). Agonist-dependent phosphorylation of GPCRs by GPCR kinases (GRKs) promotes high-affinity binding of arrestins that in turn sterically inhibit G protein interaction with the agonist-activated GPCR. There are currently four mammalian
Stuart J, Mundell +2 more
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Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
Cell, 2022Brian Kobilka, John Janetzko
exaly
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision
Cell, 2022Li-Yin Huang +2 more
exaly
The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation.
Cell, 1999G protein-coupled signaling is utilized by a wide variety of eukaryotes for communicating information from the extracellular environment. Signal termination is achieved by the action of the arrestins, which bind to activated, phosphorylated G protein-coupled receptors.
J A, Hirsch +3 more
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Plasma membrane preassociation drives β-arrestin coupling to receptors and activation
Cell, 2023Davide Calebiro, Maria Makarova
exaly
Arrestin Pathways as Drug Targets
2013Our growing appreciation of the pluridimensionality of G protein-coupled receptor (GPCR) efficacy, coupled with the phenomenon of orthosteric ligand "bias," offers the prospect of drugs that selectively modulate different aspects of GPCR function for therapeutic benefit.
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