Results 201 to 210 of about 46,183 (248)
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The Role of Arrestins in Development
2013β-Arrestins are versatile scaffolding proteins that are involved in orchestrating a large number of signaling cascades. Because β-arrestin 1 and β-arrestin 2 are individually dispensable during development, it has long been assumed that β-arrestins do not play an important role during embryogenesis.
Melanie, Philipp +2 more
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Arrestins in the Cardiovascular System
2013Of the four mammalian arrestins, only the β-arrestins (βarrs; Arrestin2 and -3) are expressed throughout the cardiovascular system, where they regulate, as either desensitizers/internalizers or signal transducers, several G-protein-coupled receptors (GPCRs) critical for cardiovascular homeostasis.
Anastasios, Lymperopoulos +1 more
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Arrestins and Protein Ubiquitination
2013The adaptor proteins, β-arrestins 1 and 2, were originally identified as inhibitors of G protein signaling at the seven-transmembrane receptors (7TMRs, also called G protein-coupled receptors or GPCRs). Subsequent studies have established β-arrestins as critical multifunctional 7TMR adaptors that mediate receptor trafficking and activate G protein ...
Reddy Peera, Kommaddi, Sudha K, Shenoy
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Arrestins in Metabolic Regulation
2013This review summarizes the regulatory roles of β-arrestins in whole-body energy balance, body weight control, and carbohydrate and lipid homeostasis. Much research has pointed in the direction of the functions of β-arrestins in mediating desensitization and endocytosis of G protein-coupled receptors as well as in activating the receptor/β-arrestin/ERK ...
Jian, Zhao, Gang, Pei
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Cone Arrestin: Deciphering the Structure and Functions of Arrestin 4 in Vision
2013Cone arrestin (Arr4) was discovered 20 years ago as a human X-chromosomal gene that is highly expressed in pinealocytes and cone photoreceptors. Subsequently, specific antibodies were developed to identify Arr4 and to distinguish cone photoreceptor morphology in health and disease states.
Cheryl Mae, Craft, Janise D, Deming
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Biochemistry, 1999
The sulfhydryl groups of the three cysteines in bovine arrestin react with DTNB very slowly (over a period of several hours). In the presence of the synthetic phosphopeptide comprising the fully phosphorylated carboxyl-terminal 19 amino acids of bovine rhodopsin, the reactivity of one of the sulfhydryls was enhanced while that of another was greatly ...
J H, McDowell +6 more
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The sulfhydryl groups of the three cysteines in bovine arrestin react with DTNB very slowly (over a period of several hours). In the presence of the synthetic phosphopeptide comprising the fully phosphorylated carboxyl-terminal 19 amino acids of bovine rhodopsin, the reactivity of one of the sulfhydryls was enhanced while that of another was greatly ...
J H, McDowell +6 more
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Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin
Cellular Signalling, 2015The G-protein coupled receptor (GPCR) Dopamine Receptor D4 (DRD4) plays an essential role in cAMP regulation and gap junctional coupling in the photoreceptors, where DRD4 expression is under circadian control. Previous in vitro transfection studies of human DRD4 desensitization have reported that DRD4 is not internalized upon dopamine stimulation when ...
Janise D, Deming +5 more
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Science's STKE, 2004
The G protein-coupled receptors (GPCRs) transduce signals elicited by many different factors, including hormones, neurotransmitters, and cytokines. Negative and positive regulation of signaling for a majority of GPCRs is controlled by receptor association with the cytoplasmic protein arrestin.
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The G protein-coupled receptors (GPCRs) transduce signals elicited by many different factors, including hormones, neurotransmitters, and cytokines. Negative and positive regulation of signaling for a majority of GPCRs is controlled by receptor association with the cytoplasmic protein arrestin.
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Permanently biased toward arrestins
Science Signaling, 2021The seven-transmembrane receptors D6R and C5aR2 are natural examples of β-arrestin–biased receptors.
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Arrestins as rheostats of GPCR signalling
Nature Reviews Molecular Cell Biology, 2018G protein-coupled receptors (GPCRs) have a central role in a myriad of physiological functions and their dysregulation underlies some of the most prevalent human diseases. They control cell behaviour and cell fate by recruiting and activating intracellular molecules such as heterotrimeric G proteins and arrestins, both of which take active roles in ...
J Silvio, Gutkind, Evi, Kostenis
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