Results 201 to 210 of about 45,700 (234)

Sulfhydryl Reactivity Demonstrates Different Conformational States for Arrestin, Arrestin Activated by a Synthetic Phosphopeptide, and Constitutively Active Arrestin

Biochemistry, 1999
The sulfhydryl groups of the three cysteines in bovine arrestin react with DTNB very slowly (over a period of several hours). In the presence of the synthetic phosphopeptide comprising the fully phosphorylated carboxyl-terminal 19 amino acids of bovine rhodopsin, the reactivity of one of the sulfhydryls was enhanced while that of another was greatly ...
J H, McDowell, W C, Smith, R L, Miller, M P, Popp, A, Arendt, G, Abdulaeva, P A, Hargrave   +6 more
openaire   +2 more sources

Arrestin Regulation of Small GTPases

2013
The regulation of small GTPases by arrestins is a relatively new way by which arrestin can exert influence over cell signalling cascades, hence, molecular interactions and specific binding partners are still being discovered. A pathway showcasing the regulation of GTPase activity by β-arrestin was first elucidated in 2001.
Ryan T, Cameron, George S, Baillie
openaire   +2 more sources

Quantifying Biased β-Arrestin Signaling

2013
It is now established that agonists do not uniformly activate pleiotropic signaling mechanisms initiated by receptors but rather can bias signals according to the unique receptor conformations they stabilize. One of the important emerging signaling systems where this can occur is through β-arrestin.
openaire   +2 more sources

Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics

Cell, 2022
John Janetzko, Brian K Kobilka
exaly  

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation

Cell, 2023
Davide Calebiro
exaly  

GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision

Cell, 2022
Wesley B Asher, Daniel S Terry, Alem W Kahsai   +2 more
exaly  

Arrestins

2022
openaire   +1 more source

Splice Variants of Arrestins

Experimental Eye Research, 1996
K, Palczewski, W C, Smith
openaire   +2 more sources

Arrestins

2013
Cornelia Walther, Stephen S.G. Ferguson
openaire   +1 more source

Arrestin Pathways as Drug Targets

2013
Our growing appreciation of the pluridimensionality of G protein-coupled receptor (GPCR) efficacy, coupled with the phenomenon of orthosteric ligand "bias," offers the prospect of drugs that selectively modulate different aspects of GPCR function for therapeutic benefit.
openaire   +2 more sources