Results 201 to 210 of about 31,759 (252)

Arrestins in Bone

2013
Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis.
Brittany N, Bohinc, Diane, Gesty-Palmer
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Diversity in arrestin function

Cellular and Molecular Life Sciences, 2009
The termination of heptahelical receptor signaling is a multilevel process coordinated, in large part, by members of the arrestin family of proteins. Arrestin binding to agonist-occupied receptors promotes desensitization by interrupting receptor-G protein coupling, while simultaneously recruiting machinery for receptor endocytosis, vesicular ...
Ryan T, Kendall, Louis M, Luttrell
openaire   +2 more sources

Arrestins lie in wait

Science Signaling, 2023
Preassociation of β-arrestins with the plasma membrane facilitates their interactions with GPCRs.
openaire   +2 more sources

Phosphorylation-dependent conformational changes of arrestin in the rhodopsin–arrestin complex

Physical Chemistry Chemical Physics, 2020
Conformations of GPCR-bound arrestin depend on the phosphorylation patterns of the GPCR C-loop.
Dali Wang, Xiangdong Liu, Jianqiang Liu, Chen Song   +3 more
openaire   +2 more sources

The Role of Arrestins in Development

2013
β-Arrestins are versatile scaffolding proteins that are involved in orchestrating a large number of signaling cascades. Because β-arrestin 1 and β-arrestin 2 are individually dispensable during development, it has long been assumed that β-arrestins do not play an important role during embryogenesis.
Melanie, Philipp, Tama, Evron, Marc G, Caron   +2 more
openaire   +2 more sources

Arrestins in Metabolic Regulation

2013
This review summarizes the regulatory roles of β-arrestins in whole-body energy balance, body weight control, and carbohydrate and lipid homeostasis. Much research has pointed in the direction of the functions of β-arrestins in mediating desensitization and endocytosis of G protein-coupled receptors as well as in activating the receptor/β-arrestin/ERK ...
Jian, Zhao, Gang, Pei
openaire   +2 more sources

Arrestins in the Cardiovascular System

2013
Of the four mammalian arrestins, only the β-arrestins (βarrs; Arrestin2 and -3) are expressed throughout the cardiovascular system, where they regulate, as either desensitizers/internalizers or signal transducers, several G-protein-coupled receptors (GPCRs) critical for cardiovascular homeostasis.
Anastasios, Lymperopoulos, Ashley, Bathgate   +1 more
openaire   +2 more sources

Arrestins and Protein Ubiquitination

2013
The adaptor proteins, β-arrestins 1 and 2, were originally identified as inhibitors of G protein signaling at the seven-transmembrane receptors (7TMRs, also called G protein-coupled receptors or GPCRs). Subsequent studies have established β-arrestins as critical multifunctional 7TMR adaptors that mediate receptor trafficking and activate G protein ...
Reddy Peera, Kommaddi, Sudha K, Shenoy
openaire   +2 more sources

Cone Arrestin: Deciphering the Structure and Functions of Arrestin 4 in Vision

2013
Cone arrestin (Arr4) was discovered 20 years ago as a human X-chromosomal gene that is highly expressed in pinealocytes and cone photoreceptors. Subsequently, specific antibodies were developed to identify Arr4 and to distinguish cone photoreceptor morphology in health and disease states.
Cheryl Mae, Craft, Janise D, Deming
openaire   +2 more sources