Results 241 to 250 of about 49,677 (283)

Steric control of signaling bias in the immunometabolic receptor GPR84

Wang P, Zhang X, Guseinov A, Jenkins L, von Hallerstein C, Colburn JD, Ives R, Luscombe VB, Marsango S, Oktavia L, Raja A, Greaves DR, Biggin PC, Milligan G, Zhang C, Tikhonova I, Russell AJ.   +16 more
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Permanently biased toward arrestins

Science Signaling, 2021
The seven-transmembrane receptors D6R and C5aR2 are natural examples of β-arrestin–biased receptors.
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Arrestins in Bone

2013
Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis.
Brittany N, Bohinc, Diane, Gesty-Palmer
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Phosphorylation-dependent conformational changes of arrestin in the rhodopsin–arrestin complex

Physical Chemistry Chemical Physics, 2020
Conformations of GPCR-bound arrestin depend on the phosphorylation patterns of the GPCR C-loop.
Dali Wang, Xiangdong Liu, Jianqiang Liu, Chen Song   +3 more
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Arrestins lie in wait

Science Signaling, 2023
Preassociation of β-arrestins with the plasma membrane facilitates their interactions with GPCRs.
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Arrestin's Nemesis

Science, 2004
The G protein-coupled receptors (GPCRs) transduce signals elicited by many different factors, including hormones, neurotransmitters, and cytokines. Negative and positive regulation of signaling for a majority of GPCRs is controlled by receptor association with the cytoplasmic protein arrestin.
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Diversity in arrestin function

Cellular and Molecular Life Sciences, 2009
The termination of heptahelical receptor signaling is a multilevel process coordinated, in large part, by members of the arrestin family of proteins. Arrestin binding to agonist-occupied receptors promotes desensitization by interrupting receptor-G protein coupling, while simultaneously recruiting machinery for receptor endocytosis, vesicular ...
Ryan T, Kendall, Louis M, Luttrell
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Arrestins in Metabolic Regulation

2013
This review summarizes the regulatory roles of β-arrestins in whole-body energy balance, body weight control, and carbohydrate and lipid homeostasis. Much research has pointed in the direction of the functions of β-arrestins in mediating desensitization and endocytosis of G protein-coupled receptors as well as in activating the receptor/β-arrestin/ERK ...
Jian, Zhao, Gang, Pei
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Arrestins and Protein Ubiquitination

2013
The adaptor proteins, β-arrestins 1 and 2, were originally identified as inhibitors of G protein signaling at the seven-transmembrane receptors (7TMRs, also called G protein-coupled receptors or GPCRs). Subsequent studies have established β-arrestins as critical multifunctional 7TMR adaptors that mediate receptor trafficking and activate G protein ...
Reddy Peera, Kommaddi, Sudha K, Shenoy
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Sulfhydryl Reactivity Demonstrates Different Conformational States for Arrestin, Arrestin Activated by a Synthetic Phosphopeptide, and Constitutively Active Arrestin

Biochemistry, 1999
The sulfhydryl groups of the three cysteines in bovine arrestin react with DTNB very slowly (over a period of several hours). In the presence of the synthetic phosphopeptide comprising the fully phosphorylated carboxyl-terminal 19 amino acids of bovine rhodopsin, the reactivity of one of the sulfhydryls was enhanced while that of another was greatly ...
J H, McDowell, W C, Smith, R L, Miller, M P, Popp, A, Arendt, G, Abdulaeva, P A, Hargrave   +6 more
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