Results 61 to 70 of about 2,626,293 (190)

Genetic Architecture of Pediatric Cardiomyopathies Assessed by Whole‐Exome Sequencing: Insights Into Early‐Onset and Syndromic Forms

Clinical Genetics, EarlyView.
Pediatric cardiomyopathies (CM) are a heterogeneous group of disorders. Their genetic basis remains poorly defined, particularly in children with early‐onset and apparently isolated forms. With a diagnostic yield of 62.7%, our findings suggest that whole‐exome sequencing could improve the diagnosis, genetic counseling, and clinical management of ...
Luana Giovannangeli, Elise Daire, Kahia Messaoudi, Didier Herent, Nathalie Desjeux, Emilie Lacot‐Leriche, Sarah Sauval, Sabine Dirani, Pascal De Groote, Didier Klug, Jean‐Benoit Baudelet, Alexandre Delarue, Olivia Domanski, Pierre‐Alexandre Fontanges, Jamal Ghoumid, Luisa Marsili, Alexis Hermida, Florence Jobic, Guillaume Jedraszak   +18 more
wiley   +1 more source

Relationship Between Electrocardiographic Findings and Cardiac Magnetic Resonance Phenotypes in Arrhythmogenic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background The new designation of arrhythmogenic cardiomyopathy defines a broader spectrum of disease phenotypes, which include right dominant, biventricular, and left dominant variants. We evaluated the relationship between electrocardiographic findings
Manuel De Lazzari, Alessandro Zorzi, Alberto Cipriani, Angela Susana, Giulio Mastella, Alessandro Rizzo, Ilaria Rigato, Barbara Bauce, Benedetta Giorgi, Carmelo Lacognata, Sabino Iliceto, Domenico Corrado, Martina Perazzolo Marra   +12 more
doaj   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Arrhythmogenic right ventricular cardiomyopathy/dysplasia

, 2016
Arrhythmogenic right ventricular cardiomyopathy (dysplasia) is discussed. Diagnosis and indications for ICD therapy are presented.
Bernard J. Gersh, Demosthenes G. Katritsis, A. John Camm   +2 more
core   +1 more source

Clinical Outcomes After Catheter Ablation in Patients With Structural Heart Disease and Ventricular Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction In patients with ischemic cardiomyopathy (ICM), recurrent VF may be treated with catheter ablation by targeting triggering premature ventricular complexes (PVCs) and/or ventricular scar homogenization. Data on optimal ablation strategies in patients with non‐ischemic cardiomyopathy (NICM) remain limited.
Kenji Hashimoto, Samual Turnbull, Saurabh Kumar   +2 more
wiley   +1 more source

The disease mutation A77V in Ryanodine receptor RyR2 induces changes in energy conduction pathways in the protein [PDF]

, 2011
Energetically responsive residues of the 217 amino acid N-terminal domain of the cardiac Ryanodine receptor RyR2 are identified by a simple elastic net model. These residues lie along a hydrogen bonded path through the protein.
Nazan Walpoth, Burak Erman
core  

First United States Experience With Focal Pulsed‐Field Ablation Using the FARAPOINT Catheter for Refractory Ventricular Tachycardia

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Drug‐refractory ventricular tachycardia (VT) after failed radiofrequency (RF) ablation remains a clinical challenge. Pulsed‐field ablation (PFA) is expanding to ventricular applications, but United States experience with focal pulsed‐field‐only catheters in VT is sparse, and pulsed‐field platforms are not equivalent across ...
Jorge L. Reyes, Rezwan Munshi, Collin Goebel, Venkat Tholakanahalli   +3 more
wiley   +1 more source

Arrhythmogenic right ventricular cardiomyopathy: diagnosis

, 2018
Arrhythmogenic cardiomyopathy is a heart muscle disease clinically characterized by life-threatening ventricular arrhythmias and pathologically by an acquired and progressive dystrophy of the ventricular myocardium with fibrofatty replacement.
Gaetano Thiene, Cristina Bass, Barbara Bauce   +2 more
core   +1 more source

Sudden cardiac death in patients with nonischemic cardiomyopathy

Indian Heart Journal, 2014
Sudden cardiac death (SCD) is an important cause of mortality worldwide. Although SCD is most often associated with coronary heart disease, the risk of SCD in patients without ischemic heart disease is well-established.
Brian P. Betensky, Sanjay Dixit
doaj   +1 more source

Feasibility, Safety, and Efficacy of Pulsed Field Ablation for Ventricular Arrhythmias: Insights From a Large Health System Registry in the United States

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Pulsed field ablation (PFA) is an emerging non‐thermal ablation modality with proven safety in atrial arrhythmia ablation. However, data on its performance for ventricular arrhythmias (VA) remain limited. Objective To evaluate the feasibility, safety, and efficacy of PFA for complex VA in a multicenter real‐world US registry ...
Narut Prasitlumkum, Juan F. Rodriguez‐Riascos, Hema Vemulapalli, Aakash Somappa, Camilo A. Estrada‐Vargas, Olubadewa A. Fatunde, Carlos A. Rojas, Poojan Prajapati, Keerthika Vijayakumar, Suraj Kapa, Duy Nguyen, Samuel Asirvatham, Malini Madhavan, Christopher McLeod, Hicham Z. El Masry, Abhishek J. Deshmukh, Danesh K. Kella, Ammar M. Killu, Siva K. Mulpuru, Mayank Sardana, Luis R. Scott, Alan M. Sugrue, Komandoor Srivathsan   +22 more
wiley   +1 more source