Results 91 to 100 of about 11,960 (207)

Development of the RP-HPLC Method for Simultaneous Determination and Quantification of Artemether and Lumefantrine in Fixed-Dose Combination Pharmaceutical Dosage Forms

Advances in Pharmacological and Pharmaceutical Sciences
Developing countries face enormous challenges with substandard and falsified antimalarial drugs. One specific issue is the lack of a simple, cost-effective, and robust HPLC method to simultaneously determine and quantify the active pharmaceutical ...
Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Desmond Asamoah Bruce Otu, Denis Dekugmen Yar, Yaa Asantewaa Osei   +6 more
doaj   +1 more source

Malaria drug shortages in Kenya: a major failure to provide access to effective treatment. [PDF]

, 2009
A key bench mark of successful therapeutic policy implementation, and thus effectiveness, is that the recommended drugs are available at the point of care.
Zurovac, D, Kangwana, Beth B, Snow, RW, Njogu, Julius, Kedenge, Sarah V, Kedenge, SV, Wasunna, B, Njogu, J, Snow, Robert, Kangwana, BB, Zurovac, Dejan, Memusi, Dorothy N, Goodman, Catherine A, Goodman, CA, Snow, Robert W, Wasunna, Beatrice, Memusi, DN   +16 more
core   +1 more source

Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial

Malaria Journal, 2008
Background Due to increasing drug resistance, artemisinin-based combination chemotherapy (ACT) has become the first-line treatment of falciparum malaria in many endemic countries. However, irreversible ototoxicity associated with artemether/lumefantrine (
Krause Eike, Girma Tsinuel, Mamo Yoseph, Berens-Riha Nicole, Miranda Isabel, Eshetu Teferi, Gürkov Robert, Schmidt Michael, Hempel John-Martin, Löscher Thomas   +9 more
doaj   +1 more source

Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania. [PDF]

, 2006
Artemisinin-based combination therapies (ACTs) are recommended for use against uncomplicated malaria in areas of multi-drug resistant malaria, such as sub-Saharan Africa.
Mugittu, Kefas, Beck, Hans Peter, Mugittu Kefas, Hassan Mshinda, Hans Beck, Mshinda Hassan, Blaise Genton, Kefas Mugittu, Genton Blaise, Beck Hans, Mshinda, Hassan, Genton, Blaise   +11 more
core   +1 more source

Assessment of the therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in northern KwaZulu-Natal: an observational cohort study

Malaria Journal, 2012
Background Recent malaria epidemics in KwaZulu-Natal indicate that effective anti-malarial therapy is essential for malaria control. Although artemether-lumefantrine has been used as first-line treatment for uncomplicated Plasmodium falciparum malaria in
Vaughan-Williams Charles H, Raman Jaishree, Raswiswi Eric, Immelman Etienne, Reichel Holger, Gate Kelly, Knight Steve   +6 more
doaj   +1 more source

Correct Dosing of Artemether-Lumefantrine for Management of Uncomplicated Malaria in Rural Tanzania: Do facility and Patient Characteristics Matter? [PDF]

, 2013
Use of artemisinin-based combination therapy (ACT), such as artemether-lumefantrine (AL), requires a strict dosing schedule that follows the drugs' pharmacokinetic properties.
Amuri, Baraka, de Savigny, Don, Kachur, S. Patrick, Irene M Masanja, Kajungu, Dan, Dan Kajungu, S Kachur, Selemani, Majige, Khatib, Rashid A., Kuepfer, Irene, Jacek Skarbinski, Rashid A Khatib, Kachur, S Patrick, Irene Kuepfer, Masanja, Irene M, Skarbinski, Jacek, Baraka Amuri, Don de Savigny, Masanja, Irene M., Majige Selemani, Khatib, Rashid A   +20 more
core   +1 more source

Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial.

PLoS Medicine, 2014
BackgroundArtemisinin combination therapies (ACTs) with broad efficacy are needed where multiple Plasmodium species are transmitted, especially in children, who bear the brunt of infection in endemic areas.
Moses Laman, Brioni R Moore, John M Benjamin, Gumul Yadi, Cathy Bona, Jonathan Warrel, Johanna H Kattenberg, Tamarah Koleala, Laurens Manning, Bernadine Kasian, Leanne J Robinson, Naomi Sambale, Lina Lorry, Stephan Karl, Wendy A Davis, Anna Rosanas-Urgell, Ivo Mueller, Peter M Siba, Inoni Betuela, Timothy M E Davis   +19 more
doaj   +1 more source

Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial. [PDF]

, 2011
BACKGROUND: The use of artemisinin-based combination therapy (ACT) is currently recommended for treating uncomplicated malaria. The objective was to assess the efficacy and safety of repeated administrations of two fixed-dose presentations of ACT ...
Gaye Oumar, Ali Gueye, Corinne Tchania, Cissé, Badara, Tchania Corinne, Ibrahima Ndiaye, Barry Aichatou, Tine Roger, Gueye Ali, Tine, Roger, Ndiaye Daouda, Ndiaye, Ibrahima, Ndiaye, Daouda, Daouda Ndiaye, Valérie Lameyre, Gueye, Ali, Ndiaye Jean-Louis A, Roger Tine, Aichatou Barry, Tchania, Corinne, Faye, Babacar, Babacar Faye, Lameyre, Valérie, Cissé Badara, Ndiaye Ibrahima, Barry, Aichatou, Gaye, Oumar, Oumar Gaye, Faye Babacar, Ndiaye, Jean-Louis A, Jean-Louis A Ndiaye, Lameyre Valérie, Badara Cissé   +32 more
core   +1 more source

PHARMACOKINETICS OF LUMEFANTRINE IN HEALTHY PAKISTANI VOLUNTEERS

Pakistan Armed Forces Medical Journal, 2011
Objective: To study the pharmacokinetics of lumefantrine in healthy Pakistani volunteers so as to see the adequacy of the regimen in vogue for the treatment of malaria and prevention of recrudescence.
Nusrat Jafery, Muzammil Hassan Najmi
doaj   +2 more sources

Clinical Pharmacokinetics and Pharmacodynamics of Artemether-Lumefantrine

Clinical Pharmacokinetics, 1999
The combination of artemether and lumefantrine (benflumetol) is a new and very well tolerated oral antimalarial drug effective even against multidrug-resistant falciparum malaria. The artemether component is absorbed rapidly and biotransformed to dihydroartemisinin, and both are eliminated with terminal half-lives of around 1 hour.
White, N, van Vugt, M, Ezzet, F
openaire   +2 more sources