Results 71 to 80 of about 11,960 (207)

A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand

Malaria Journal, 2005
Background The use of antimalarial drug combinations with artemisinin derivatives is recommended to overcome drug resistance in Plasmodium falciparum.
McGready Rose, Ashley Elizabeth A, Paiphun Lucy, Hutagalung Robert, Brockman Alan, Thwai Kaw L, Singhasivanon Pratap, Jelinek Thomas, White Nicholas J, Nosten François H   +9 more
doaj   +1 more source

Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India

Malaria Journal, 2021
Background Malaria is a major public health problem in India and accounts for about 88% of malaria burden in South-East Asia. India alone accounted for 2% of total malaria cases globally.
Sri Krishna, Sweta Mishra, Prakash Tiwari, Anup K. Vishwakarma, Sushrikanta Khandai, Suyesh Shrivastava, Anil K. Verma, Shashikant Tiwari, Hari Barman, Surendra Jhariya, Pradeep Tiwari, Anup S. Tidgam, Brij M. Varun, Sunil Singh, Naresh Yerane, Chintaman R. Tembhurne, Prem L. Mandavi, Shyam S. Tekam, Manas Malik, Kali P. Behera, Himanshu Jayswar, Khemraj Sonwani, Mukund S. Diggikar, Madan M. Pradhan, Sher S. Khasotiya, Avdhesh Kumar, Neeraj Dhingra, Maria Dorina G. Bustos, Eva-Maria Christophel, Pascal Ringwald, Roop Kumari, Man M. Shukla, Neeru Singh, Aparup Das, Praveen K. Bharti   +34 more
doaj   +1 more source

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, Volume 31, Issue 3, Page 254-273, March 2026.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

A Comparison of Pharmacokinetics of two Tablet Formulations Containing Artemether / Lumefantrine – Quality Criteria for Malaria Treatment Assurance [PDF]

, 2012
\ud Treatment of non-severe malaria remains a challenge to endemic areas including Tanzania. Since November 2006, Coartem® an artemisinin based combination therapy (ACT) containing artemether-lumefantrine (ALu), replaced sulphadoxine/pyrimethamine (SP ...
Alphonce, Ignace
core  

Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. [PDF]

, 2004
Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its ...
Bajunirwe, F, Bajunirwe, Francis, Guthmann, J P, Piola, P, Musabe, Joy, Namiiro, P, Piola, Patrice, Biraro, S, Checchi, F, Namiiro, Proscovia, Checchi, Francesco, Guthmann, Jean-Paul, Biraro, Samuel, Kyomugisha, A, Musabe, J, Kiguli, James, Kiguli, J, Kyomugisha, Agnes, Fogg, C, Fogg, Carole   +19 more
core   +1 more source

The clinical efficacy of artemether/lumefantrine (Coartem®) [PDF]

Malaria Journal, 2009
Las directrices actuales de la Organización Mundial de la Salud (OMS) para el tratamiento de la malaria falciparum no complicada recomiendan el uso de la terapia combinada basada en artemisinina (ACT). Arteméter/lumefantrina es un ACTO precalificado por la OMS por su eficacia, seguridad y calidad, aprobado por Swissmedic en diciembre de 2008 y ...
Michael Makanga, Srivicha Krudsood
openaire   +2 more sources

Antimalarial Polyethylene Glycol–Lumefantrine Conjugates: Synthesis and Effect of Linker Chemistry on Drug Release

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Research into advanced therapeutics for malaria are rare. We investigate how linker chemistry governs the release kinetics of the antimalarial lumefantrine from polyethylene glycol conjugates. A clear correlation between diacid linker length and drug release rate is established, enabling rational design of conjugates with controlled release.
Thenesia R. Govender, William M. R. Matshe, Nokuthula Dube, Zamani E. D. Cele, Aurelia A. Williams, Lynne A. Pilcher, Mohammed O. Balogun   +6 more
wiley   +1 more source

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Rosalba Lepore, LEPORE, ROSALBA, Pillai, DR, Via Allegra, K. Khairnar, Khairnar Krishna, Rachel Lau, Pillai Dylan R, D. R. Pillai, VIA, ALLEGRA, Dylan R Pillai, Henry M Staines, Krishna Sanjeev, S. Krishna, Lau, R, Khairnar, K, Lau Rachel, Via, A, Staines, HM, H. M. Staines, Krishna, S, Sanjeev Krishna, Krishna Khairnar, Lepore, R, Allegra Via, R. Lau, Lepore Rosalba, Staines Henry M   +27 more
core   +1 more source

Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 317-322, January 2026.
In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Meg K. Tully, Robert J. Commons, Julie A. Simpson, David J. Price   +3 more
wiley   +1 more source

Paediatric malaria case-management with artemether-lumefantrine in Zambia: a repeat cross-sectional study

Malaria Journal, 2007
Background Zambia was the first African country to change national antimalarial treatment policy to artemisinin-based combination therapy – artemether-lumefantrine.
Chanda Pascalina, Hamer Davidson H, Sipilanyambe Nawa, Ndhlovu Mickey, Zurovac Dejan, Simon Jon L, Snow Robert W   +6 more
doaj   +1 more source