Results 51 to 60 of about 7,763 (163)

Therapeutic efficacy of artemether-lumefantrine for Plasmodium vivax infections in a prospective study in Guyana

Malaria Journal, 2012
Background In Guyana, chloroquine + primaquine is used for the treatment of vivax malaria. A worldwide increase of chloroquine resistance in Plasmodium vivax led to questioning of the current malaria treatment guidelines. A therapeutic efficacy study was
Eibach Daniel, Ceron Nicolas, Krishnalall Karanchand, Carter Keith, Bonnot Guillaume, Bienvenu Anne-Lise, Picot Stéphane   +6 more
doaj   +1 more source

Severe Plasmodium knowlesi Malaria in a Tertiary Care Hospital, Sabah, Malaysia

Emerging Infectious Diseases, 2011
The simian parasite Plasmodium knowlesi causes severe human malaria; the optimal treatment remains unknown. We describe the clinical features, disease spectrum, and response to antimalarial chemotherapy, including artemether-lumefantrine and artesunate ...
Timothy William, Jayaram Menon, Giri S. Rajahram, Leslie Chan, Gordon Ma, Samantha Donaldson, Serena Khoo, Charlie Fredrick, Jenarun Jelip, Nicholas M. Anstey, Tsin Wen Yeo   +10 more
doaj   +1 more source

Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 317-322, January 2026.
In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Meg K. Tully, Robert J. Commons, Julie A. Simpson, David J. Price   +3 more
wiley   +1 more source

Malaria Screening and Treatment in Hematopoietic Cell Transplant Donors and Sickle Cell Disease Candidates/Recipients: A Case Series Using Malaria Polymerase Chain Reaction Testing and a Literature Review

Transplant Infectious Disease, Volume 28, Issue 1, January/February 2026.
Malaria polymerase chain reaction (PCR) testing is more sensitive than conventional diagnostics. Routine PCR screening of at‐risk asymptomatic hematopoietic cell donors and transplant candidates may prevent unnecessary deferrals or treatment. In our experience, PCR negativity during screening or after treatment supports donor/candidate eligibility ...
Mary M. Czech, Sanchita Das, Emily Limerick, Courtney Fitzhugh, Matthew Hsieh, Jennifer Cuellar‐Rodriguez   +5 more
wiley   +1 more source

Artemether/Lumefantrine for the Treatment of P. malariae in a Patient on Hemodialysis

Case Reports in Medicine, 2019
The combination of artemether/lumefantrine is indicated for the treatment of acute uncomplicated Plasmodium falciparum malaria. There have been no clinical trials to assess the efficacy of this medication in patients with renal impairment.
Rita Patrocínio-Jesus, João Cunha, Diva Trigo, Bárbara Flor-de-Lima, Patrícia Pacheco   +4 more
doaj   +1 more source

Development of the RP-HPLC Method for Simultaneous Determination and Quantification of Artemether and Lumefantrine in Fixed-Dose Combination Pharmaceutical Dosage Forms

Advances in Pharmacological and Pharmaceutical Sciences
Developing countries face enormous challenges with substandard and falsified antimalarial drugs. One specific issue is the lack of a simple, cost-effective, and robust HPLC method to simultaneously determine and quantify the active pharmaceutical ...
Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Desmond Asamoah Bruce Otu, Denis Dekugmen Yar, Yaa Asantewaa Osei   +6 more
doaj   +1 more source

Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial

Malaria Journal, 2008
Background Due to increasing drug resistance, artemisinin-based combination chemotherapy (ACT) has become the first-line treatment of falciparum malaria in many endemic countries. However, irreversible ototoxicity associated with artemether/lumefantrine (
Krause Eike, Girma Tsinuel, Mamo Yoseph, Berens-Riha Nicole, Miranda Isabel, Eshetu Teferi, Gürkov Robert, Schmidt Michael, Hempel John-Martin, Löscher Thomas   +9 more
doaj   +1 more source

Assessment of the therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in northern KwaZulu-Natal: an observational cohort study

Malaria Journal, 2012
Background Recent malaria epidemics in KwaZulu-Natal indicate that effective anti-malarial therapy is essential for malaria control. Although artemether-lumefantrine has been used as first-line treatment for uncomplicated Plasmodium falciparum malaria in
Vaughan-Williams Charles H, Raman Jaishree, Raswiswi Eric, Immelman Etienne, Reichel Holger, Gate Kelly, Knight Steve   +6 more
doaj   +1 more source

Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial.

PLoS Medicine, 2014
BackgroundArtemisinin combination therapies (ACTs) with broad efficacy are needed where multiple Plasmodium species are transmitted, especially in children, who bear the brunt of infection in endemic areas.
Moses Laman, Brioni R Moore, John M Benjamin, Gumul Yadi, Cathy Bona, Jonathan Warrel, Johanna H Kattenberg, Tamarah Koleala, Laurens Manning, Bernadine Kasian, Leanne J Robinson, Naomi Sambale, Lina Lorry, Stephan Karl, Wendy A Davis, Anna Rosanas-Urgell, Ivo Mueller, Peter M Siba, Inoni Betuela, Timothy M E Davis   +19 more
doaj   +1 more source

PHARMACOKINETICS OF LUMEFANTRINE IN HEALTHY PAKISTANI VOLUNTEERS

Pakistan Armed Forces Medical Journal, 2011
Objective: To study the pharmacokinetics of lumefantrine in healthy Pakistani volunteers so as to see the adequacy of the regimen in vogue for the treatment of malaria and prevention of recrudescence.
Nusrat Jafery, Muzammil Hassan Najmi
doaj   +2 more sources