Results 41 to 50 of about 11,960 (207)

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. [PDF]

, 2007
OBJECTIVES: To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda. DESIGN: Randomized single-blinded clinical trial.
Staedke Sarah G, Wabwire-Mangen, F, Yeka Adoke, Rwakimari, JB, Dorsey, Grant, Rwakimari John B, Nosten François, Talisuna, Ambrose O, Dorsey Grant, Kamya, MR, Greenhouse Bryan, Rosenthal, PJ, Greenhouse, B, Rosenthal Philip J, Staedke, SG, Nosten, F, Lugemwa, Myers, Rosenthal, Philip J, Yeka, Adoke, Dorsey, G, Staedke, Sarah G, Greenhouse, Bryan, Rwakimari, John B, Bukirwa, H, Bukirwa, Hasifa, Lugemwa, M, Kamya Moses R, Lugemwa Myers, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Talisuna Ambrose O, Wabwire-Mangen, Fred, Talisuna, AO, Nosten, François, Yeka, A   +35 more
core   +1 more source

The Content of African Diets is Adequate to Achieve Optimal Efficacy with Fixed-Dose Artemether-Lumefantrine: A Review of the Evidence. [PDF]

, 2008
A fixed-dose combination of artemether-lumefantrine (AL, Coartem(R)) has shown high efficacy, good tolerability and cost-effectiveness in adults and children with uncomplicated malaria caused by Plasmodium falciparum.
Nathan Mulure, Abdulla, Salim, Kokwaro, Gilbert, Salim Abdulla, Mulure, Nathan, Ndong, A, Zulfiqarali G Premji, Ndong, A., Alice Ndong, Gilbert Kokwaro, Abdulla, S., Ndong, Alice, Mulure, N., Nwaiwu, Obiyo, Premji, Zul, Nwaiwu, O., Ogutu, Bernhards, Falade, C.O., Premji, Zulfiqarali G, Falade, Catherine O, Catherine O Falade, Sagara, Issaka, Sagara, I., Obiyo Nwaiwu, Ogutu, B., Bernhards Ogutu, Premji, Z.G., Kokwaro, G., Issaka Sagara   +28 more
core   +1 more source

Malaria‐Associated Secondary Hematophagocytic Lymphohistocytosis—A Case Report and Comprehensive Literature Review (sHLH)

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Malaria‐associated secondary HLH, though rare, is often overlooked. Clinicians should maintain a high‐index of suspicion in travelers returning from malaria‐endemic regions who develop severe to rapidly worsening inflammatory illness, as early recognition is critical for survival.
Indresh Yadav, Sulav Kumar Jha, Sweta Singh, Dipesh Kumar Mandal, Saurav Jha   +4 more
wiley   +1 more source

Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia. [PDF]

, 2011
BACKGROUND: Chlorproguanil-dapsone (Lapdap), developed as a low-cost antimalarial, was withdrawn in 2008 after concerns about safety in G6PD deficient patients.
Njie, Fanta, Bisseye, C, Nwakanma, D, Snell, P., Walton, Robert T., Conway D., Nwakanma, Davis, Cyrille Bisseye, Joof F., Sesay, Sanie, Milligan P., Walton, R, Sanie Sesay, Snell Paul, Joof, F., Snell P., Cheung, Yin Bun, Milligan Paul, Sesay S., Sesay, S, Bisseye C., Diatta Mathurin, Bisseye, Cyrille, Njie, F, Dunyo, Samuel, Janha, R., Adiamoh, M, Adiamoh, Majidah, Njie F., Janha, Ramatoulie, Temple B., Temple, B., Diatta, Mathurin, Cheung Yin Bun, Ramatoulie Janha, Yin Bun Cheung, Nwakanma, D., Diatta M., David Conway, Temple, Beth, Snell, P, Walton R., Janha, R, Sisay Joof Fatou, Robert Walton, Sisay Joof, F, Samuel Dunyo, Conway, D., Sirugo, G, Sirugo, G., Dunyo, S., Nwakanma D., Temple, B, Sirugo, Giorgio, Janha Ramatoulie, Dunyo S., Njie, F., Dunyo, S, Nwakanma Davis, Paul Milligan, Walton Robert, Beth Temple, Conway, David, Mathurin Diatta, Paul Snell, Bisseye Cyrille, Sesay, S., Cheung, YB, Temple Beth, Janha R., Adiamoh, M., Milligan, Paul, Milligan, P., Cheung Y.B., Bisseye, C., Fatou Sisay Joof, Walton, Robert, Sesay Sanie, Diatta, M., Conway David, Sirugo G., Diatta, M, Majidah Adiamoh, Davis Nwakanma, Njie Fanta, Adiamoh M., Snell, Paul, Milligan, P, Sisay Joof, Fatou, Sirugo Giorgio, Dunyo Samuel, Conway, D, Fanta Njie, Adiamoh Majidah, Giorgio Sirugo, Cheung, Y. B.   +95 more
core   +1 more source

Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania

Malaria Journal, 2012
Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa.
Färnert Anna, Ursing Johan, Tolfvenstam Thomas, Rono Josea, Karlsson Lillemor, Sparrelid Elda, Lindegårdh Niklas   +6 more
doaj   +1 more source

Age‐Related and Seasonal Variation in Malaria and Other Causes of Fever and Their Association With Clinical Outcomes in Southern Angola: A Hospital‐Based Study

Tropical Medicine &International Health, Volume 31, Issue 9, Page 1273-1283, September 2026.
ABSTRACT Background Acute febrile illnesses in sub‐Saharan Africa are often attributed to malaria, yet many patients test negative for malaria parasites. The aetiology of nonmalarial fevers remains understudied. Here, we examine likely causes of febrile illnesses and their association with poor clinical outcomes in Angola.
Helga E. M. Gonçalves, Maria Lina Antunes, Jorge Seixas, Marcelo U. Ferreira   +3 more
wiley   +1 more source

Coartem: the Journey to the Clinic. [PDF]

, 2009
Artemisinin, from which the artemether component of Coartem (artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chinese herbal remedy.
Premji, Zulfiqarali G, Premji, Z.G., Premji, Zul   +2 more
core   +1 more source

Usefulness of combined screening methods for rapid detection of falsified and/or substandard medicines in the absence of a confirmatory method

Malaria Journal, 2019
Background The influx of substandard and falsified medicines is a global public health challenge and its rapid detection is a key solution to the menace. This study used three screening methods and one confirmatory method for the quality assessment of 25
Kwabena Frimpong-Manso Opuni, Henry Nettey, Marvin Adjei Larbi, Salome Naa Amerley Amartey, Gifty Nti, Abraham Dzidonu, Patrick Owusu-Danso, Nicholas Amoah Owusu, Alexander Kwadwo Nyarko   +8 more
doaj   +1 more source

Green Chiral HPLC Method for Lumefantrine Analysis: Method Development, Greenness Assessment, and Computational Studies

Chirality, Volume 38, Issue 8, August 2026.
A green chiral HPLC method was developed and validated for the determination of lumefantrine enantiomers. The method employs ethanol as a mobile phase as a sustainable and efficient alternative to hexane. The chiral recognition mechanism and elution order of the enantiomers were investigated using electronic circular dichroism and molecular docking ...
Amanda Mohr, Gustavo Machado das Neves, Érika Segala, Vera Lucia Eifler‐Lima, Martin Steppe   +4 more
wiley   +1 more source

Simultaneous Estimation of Artemether and Lumefantrine by RP-HPLC Method Development in Pharmaceutical Tablet Dosage Form

RGUHS Journal of Pharmaceutical Sciences
Background Artemether and Lumefantrine are widely used antimalarial agents whose simultaneous quantification in tablet formulations is essential for quality control.Objectives To develop and validate a simple accurate and robust ...
Lekhana A M, Paul Richards M, Vishwanath BA   +2 more
doaj   +1 more source