Results 91 to 100 of about 63,940 (276)

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Adjuik, M, Barnes, K, Day, N P J, Farrar, J, Guthmann, J P, Hien, T T, Looareesuwan, S, Mayxay, M, Myint, H Y, Nosten, F, Olliaro, P, Price, R, Pukrittayakamee, S, Smithuis, F, Stepniewska, K, Taylor, W R J, White, N J   +16 more
core   +3 more sources

Metabolomic and Single‐Cell Transcriptomic Analyses Shed Light on Secondary Metabolite Profiling and Potential Developmental Dynamics of Glandular Trichomes in Artemisia argyi

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant glandular trichomes (GTs) are characterised by their ability to synthesise and store abundant secondary metabolites of significant biological importance. The medicinal plant Artemisia argyi exhibits a dense covering of GTs, yet the precise metabolic compositions and the developmental molecular dynamics of A.
Shuting Dong, Hongyu Chen, Sijie Sun, Miaoxian Guo, Chao Sun, Shilin Chen, Hongmei Luo   +6 more
wiley   +1 more source

Automatic differential analysis of NMR experiments in complex samples

, 2017
Liquid state NMR is a powerful tool for the analysis of complex mixtures of unknown molecules. This capacity has been used in many analytical approaches: metabolomics, identification of active compounds in natural extracts, characterization of species ...
Bourjot, Mélanie, Chiron, Lionel, Delsuc, Marc-André, Margueritte, Laure, Markov, Petar, Starck, Jean-Philippe, Vonthron-Sénécheau, Catherine   +6 more
core   +2 more sources

Potential P-Glycoprotein-Mediated Drug-Drug Interactions of Antimalarial Agents in Caco-2 cells [PDF]

, 2012
Antimalarials are widely used in African and Southeast Asian countries, where they are combined with other drugs for the treatment of concurrent ailments.
Horie, Toshiharu, Oga, Enoche, Shitara, Yoshihisa, Shuichi, Sekine   +3 more
core   +1 more source

The Potential of Artemisinins as Novel Treatment for Thyroid Eye Disease by Inhibiting Adipogenesis in Orbital Fibroblasts [PDF]

, 2023
Yan Guo, Yanglei Cheng, Hai Li, Hongyu Guan, Haipeng Xiao, Yanbing Li   +5 more
openalex   +1 more source

Jasmonate‐Activated AaWRKY9–AabHLH93/AabHLH93–AaMYB7 Complexes Balance Artemisinin Biosynthesis in Artemisia annua

Plant Biotechnology Journal, EarlyView.
ABSTRACT Artemisinin, an antimalarial sesquiterpene lactone, is biosynthesized in glandular trichomes of Artemisia annua. Although numerous transcription factors have been demonstrated to regulate artemisinin biosynthesis, the molecular mechanisms underlying the high expression of artemisinin‐associated biosynthetic enzyme and transcription factor ...
Xueqing Fu, Han Zheng, Yaojie Zhang, Muyao Yu, Shu Li, Hang Liu, Pin Liu, Ling Li, Xiaofen Sun, Jingya Zhao, Yuliang Wang, Kexuan Tang   +11 more
wiley   +1 more source

Construction of an uricase/catalase/curcumin-co-loaded drug delivery system and its effect on hyper-uric acid-induced kidney injury

Smart Materials in Medicine
Hyper-uric acid (UA)-induced kidney injury (HAKI) is caused by the deposition of excess blood UA into the kidneys. We confined molecules of uricase (URI), catalase (CAT), and curcumin (Cur) to a single structure (UC/Cur) while retaining their enzymatic ...
Yang Zhang, Xiaobo Li, Chunling Liang, Jianjia Feng, Chuyi Yu, Weichi Jiang, Keneng Cai, Wanying Chen, Wenli Cai, Feng Zeng, Qin Xu, Peng Chen, Jianming Liang   +12 more
doaj   +1 more source

Artemisinin

HIMALAYA, 2019
Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material. The ‘active principle’ was first extracted in 1820 and named quinine.
openaire   +1 more source

Heterologous Production of Forskolin in Tobacco (Nicotiana tabacum) via Glandular Trichome Specific Engineering and Metabolic Flux Redirection

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plants are promising bioreactor for the sustainable and scalable production of high‐value natural bioactive compounds, because they can synthesise phytochemicals from CO2, light, water and minerals through their innate photosynthetic carbon assimilation machinery.
Xuan Sun, Xiuming Wu, Xun Jiang, Hongmei Huang, Aiguo Yang, Yiting Li, Zhenjun Fan, Aixia Chang, Changqing Yang   +8 more
wiley   +1 more source

A non-randomized, open-label study to assess the impact of rounds of mass drug administration with artemisinin-piperaquine plus primaquine on malaria in São Tomé Island

Parasites & Vectors
Background The aim of this study was to explore the effect of mass drug administration (MDA) on malaria transmission in low-endemic malaria areas. Methods Mass drug administration of artemisinin-piperaquine (AP) + primaquine (PMQ) was targeted to 17,438 ...
Mingqiang Li, Ruixiang Tan, Peiting Chen, Herodes Sacramento Rampao, Carlos Alberto Bandeira D’almeida, Guoming Li, Jingwen Liu, Guozhuang Shi, Fei Chen, Lei Shu, Xinan Huang, Changsheng Deng, Wenfeng Guo, Jianping Song   +13 more
doaj   +1 more source