Results 91 to 100 of about 74,638 (327)

AaWRKY17, a positive regulator of artemisinin biosynthesis, is involved in resistance to Pseudomonas syringae in Artemisia annua

Horticulture Research, 2021
Artemisia annua , a traditional Chinese medicinal plant, remains the only plant source for artemisinin production, yet few genes have been identified to be involved in both the response to biotic stresses, such as pathogens, and artemisinin biosynthesis.
Tiantian Chen, Yongpeng Li, Lihui Xie, Xiaolong Hao, Hang Liu, W. Qin, Chen Wang, Xin Yan, Kuanyu Wu-Zhang, Xinghao Yao, B. Peng, Yaojie Zhang, Xueqing Fu, Ling Li, K. Tang   +14 more
semanticscholar   +1 more source

Artemisinin: From Chinese Herbal Medicine to Modern Chemotherapy [PDF]

, 2019
Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material.
Butler, Anthony
core   +1 more source

Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission [PDF]

, 2012
<p>Background: Artemisinin-based combination therapy (ACT) for treating malaria has activity against immature gametocytes. In theory, this property may complement the effect of terminating otherwise lengthy malaria infections and reducing the ...
Abdulla, S.K., Charlwood, D.J., Ferguson, H., Huho, B.J., Kachur, S.P., Kihonda, A., Kihonda, J., Killeen, G.F., Lengeler, C., Smith, T., Tami, A.   +10 more
core   +6 more sources

A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers

Journal of Pharmaceutical Analysis, 2022
The composition of serum is extremely complex, which complicates the discovery of new pharmacodynamic biomarkers via serum proteome for disease prediction and diagnosis.
Yuqing Meng, Jiayun Chen, Yanqing Liu, Yongping Zhu, Yin-Kwan Wong, Haining Lyu, Qiaoli Shi, Fei Xia, Liwei Gu, Xinwei Zhang, Peng Gao, Huan Tang, Qiuyan Guo, Chong Qiu, Chengchao Xu, Xiao He, Junzhe Zhang, Jigang Wang   +17 more
doaj  

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

Socially-marketed rapid diagnostic tests and ACT in the private sector: ten years of experience in Cambodia. [PDF]

, 2011
Whilst some populations have recently experienced dramatic declines in malaria, the majority of those most at risk of Plasmodium falciparum malaria still lack access to effective treatment with artemisinin combination therapy (ACT) and others are already
A Marriot, A Talisuna, AM Dondorp, C Whitty, Cambodia National Institute of Public Health, Cambodia National Institute of Public Health, Cambodia National Institute of Public Health and Malaria Consortium, Cambodia National Institute of Public Health and National Institute of Statistics and ORC Macro, CG Kone, CIR Chandler, CS Molyneux, D Montagu, Duong Socheat, E Patouillard, E Patouillard, E Patouillard, E Rutebemberwa, Edith Patouillard, European Commission Cambodian Malaria Control Programme, G Yamey, GFATM, WHO, H Noedl, Henrietta Allen, IA Agyepong, Institute of Medicine, J Rozendaal, JD Njau, L Bury, LA Salako, Ministry of Health Department of Planning and Health Information, Ministry of Health National Centre for Parasitology, Ministry of Health National Centre for Parasitology Entomology and Malaria Control Programme, MJ Hamel, N Kikumbih, National Institute of Statistics Ministry of Planning of the Kingdom of Cambodia, O Sabot, OJ Sabot, PSI, PSI, PSI, Cambodia, RBM Task Force, RW Snow, S Incardona, S Yeung, SC McCombie, SD Foster, Shunmay Yeung, TK Ruebush, URC-MCC, WHO, World Health Organization, World Health Organization   +51 more
core   +4 more sources

Differentially expressed genes during contrasting growth stages of Artemisia annua for artemisinin content. [PDF]

PLoS ONE, 2013
Artemisia annua is the source of antimalarial phytomolecule, artemisinin. It is mainly produced and stored in the glandular secretory trichomes present in the leaves of the plant.
Priya Nair, Amita Misra, Alka Singh, Ashutosh K Shukla, Madan M Gupta, Anil K Gupta, Vikrant Gupta, Suman P S Khanuja, Ajit K Shasany   +8 more
doaj   +1 more source

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs

Advanced NanoBiomed Research, EarlyView.
Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng   +11 more
wiley   +1 more source

Antimalarial-agent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine: potential repurposing of artenimol for COVID-19

Journal of Biomolecular Structure and Dynamics, 2020
Medicinal herbs have proved along history to be a source of multiple cures. In this paper, we demonstrate how hydroxychloroquine can act as a good inhibitor of SARS-CoV-2 Spike protein receptor-binding-domain using molecular docking studies.
M. Sehailia, S. Chemat
semanticscholar   +1 more source

Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]

, 2013
The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
core   +1 more source