Results 101 to 110 of about 74,638 (327)

In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACT In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 μM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E ...
Spicher, M., Roethlisberger, C., Lany, C., Stadelmann, B., Keiser, J., Ortega-Mora, L. M., Gottstein, B., Hemphill, A.   +7 more
openaire   +3 more sources

Artemisinin Inhibits the Migration and Invasion in Uveal Melanoma via Inhibition of the PI3K/AKT/mTOR Signaling Pathway

Oxidative Medicine and Cellular Longevity, 2021
Uveal melanoma is the most common primary ocular neoplasm in adults, with many patients ending up developing liver metastasis and facing a significant reduction of their life expectancy due to the lack of efficient treatments.
Mohd Farhan, Marta Silva, Xing Xingan, Zhiwei Zhou, Wenhua Zheng   +4 more
semanticscholar   +1 more source

PNAS plus: plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state [PDF]

, 2012
The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids. Its amino acid needs are met largely through the degradation of host erythrocyte hemoglobin; however the parasite must acquire isoleucine exogenously, because this ...
Baertl, Bozdech, Brennand, C. Doerig, C. Fennell, Callebaut, Codd, D. E. Goldberg, Daily, Dever, Divo, Dyer, E. S. Istvan, Fennell, Fidock, Francis, Functional Genomics Workshop Group, Harris, Hinnebusch, Hinnebusch, Kafsack, Kilberg, Kim, Kourtis, L. Altenhofen, Lambros, Llinas, Lu, Lu, M. Llinas, Olszewski, Payne, Pfaller, Roth, Russo, S. A. Cobbold, S. E. Babbitt, Sharma, Sherman, Sims, Soeters, Towbin, Trager, van Werven, Wek, Zaborske, Zolg   +46 more
core   +1 more source

Effect and mechanisms of shikonin on breast cancer cells in vitro and in vivo

BMC Complementary Medicine and Therapies
Background Breast cancer seriously affects physical and mental health of women. Despite advances in the clinical use of different treatments, breast cancer remains a major cause of mortality.
Chuyi Yu, Haoyu Xing, Xiaguo Fu, Yingying Zhang, Xiufang Yan, Jianjia Feng, Zhouqin He, Li Ru, Chunlong Huang, Jianming Liang   +9 more
doaj   +1 more source

Biosynthese des Rotalgen‐Diterpens Peyssonnosol in Bakterien

Angewandte Chemie, EarlyView.
Zwei Terpensynthasen aus Anaerolineae‐Bakterien katalysieren die Biosynthese von Peyssonnosen‐artigen Diterpenen aus Rotalgen. Ortsgerichtete Mutagenese ermöglichte einen partiellen Funktionswechsel, der zur Bildung zusätzlicher Nebenprodukte führte.
Zhiyong Yin, Zhehui Hu, Kexin Yang, Guihu Lu, Georges B. Tabekoueng, Pingping Wu, Qi Luo, Juan Xu, Bernd Goldfuss, Jeroen S. Dickschat, Guangkai Bian   +10 more
wiley   +1 more source

Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in Southeast of Tanzania

Scientific Reports, 2020
In Tanzania, chloroquine was replaced by sulphadoxine- pyrimethamine (SP) as a first-line for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP lasted for only 5 years and by the end of 2006 it was replaced with the ...
G. Bwire, B. Ngasala, W. Mikomangwa, Manase Kilonzi, A. Kamuhabwa   +4 more
semanticscholar   +1 more source

Simultaneous Quantitative Determination of Six Caffeoylquinic Acids in Matricaria chamomilla L. with High-Performance Liquid Chromatography

Journal of Chemistry, 2019
A simple and effective method for the simultaneous quantitative analysis of six caffeoylquinic acids (CAs) in Matricaria chamomilla L. (M. chamomilla) using high-performance liquid chromatography (HPLC) with diode-array detection (DAD) was established ...
Yifan Zhao, Peng Sun, Yue Ma, Kun Wang, Xiaoqiang Chang, Yue Bai, Dong Zhang, Lan Yang   +7 more
doaj   +1 more source

Discovery of Artemisinin (Qinghaosu) [PDF]

Molecules, 2009
Artemisinin (Qinghaosu), a new antimalarial drug, was discovered in China in the early 1970s. The discovery of artemisinin is attributed to You-You Tu, at that time a middle-aged phytochemist working in the Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine.
openaire   +3 more sources

Interfacial Photoelectrochemistry in Organic Synthesis

Angewandte Chemie International Edition, Accepted Article.
Photoelectrodes have traditionally enjoyed widespread attention as heterogeneous catalysts for the activation of water and CO2 in energy research, while photoelectrochemistry with homogeneous molecular catalysts dominates the activations of more complex molecules in organic synthesis.
Gabriel Chan, Daria Corsi, Oleksandr Savateev, Paolo Giusto, Joshua Philip Barham   +4 more
wiley   +1 more source

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources