Results 111 to 120 of about 74,638 (327)
Science of Traditional Chinese Medicine. Background. Neuroblastoma (NB) is a malignant pediatric tumor requiring new therapies. Accumulating evidence has confirmed that microRNAs play critical roles in NB metastasis.
Lina Chen +11 more
doaj +1 more source
Neurotoxic Mode of Action of Artemisinin [PDF]
Antimicrobial Agents and Chemotherapy, 2002 ABSTRACT We recently described a screening system designed to detect neurotoxicity of artemisinin derivatives based on primary neuronal brain stem cell cultures (G. Schmuck and R. K. Haynes, Neurotoxicity Res. 2:37-49, 2000). Here, we probe possible mechanisms of this brain stem-specific neurodegeneration, in which artemisinin-sensitive ...
Schmuck, G. +3 more
openaire +4 more sources
Costing Artemisinin-based Combination Therapy for Malaria in Tanzania [PDF]
, 2005 Malaria continues to be a major contributor to the burden of disease in Tanzania, with a prevalence of 33.39 percent nationally. As antimalarial resistance to sulfadoxine-pyrimethamine in Tanzania continues to grow, the government is in the process of ...
Derriennic, Yann, Wolf, Katherine
core
Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin [PDF]
, 2012 A four compartment mechanistic mathematical model is developed for the pharmacokinetics of the commonly used anti-malarial drug artesunate and its principle metabolite dihydroartemisinin following oral administration of artesunate.
Adam J. Hall +36 more
core +2 more sources
Global Health Journal, 2021 From providing funds for the global fight against infectious diseases, to actively participating in global health security actions, to strengthening mutual cooperation in the field of health, and providing medical treatment, training and scholarships to ...
Qi Wang +5 more
doaj
Biosynthesis of the Red Algal Diterpene Peyssonnosol in Bacteria
Angewandte Chemie International Edition, EarlyView.Two terpene synthases derived from Anaerolineae bacteria catalyse the biosynthesis of peyssonnosene‐type diterpenes from red algae. Site‐directed mutagenesis enabled a partial functional switch, resulting in the formation of additional byproducts. The intricate cyclisation mechanisms were investigated through isotopic labelling experiments and density ...
Zhiyong Yin +10 more
wiley +1 more source
Automatic differential analysis of NMR experiments in complex samples
, 2017 Liquid state NMR is a powerful tool for the analysis of complex mixtures of unknown molecules. This capacity has been used in many analytical approaches: metabolomics, identification of active compounds in natural extracts, characterization of species ...
Bourjot, Mélanie +6 more
core +2 more sources
Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review [PDF]
, 2018 Increasing drug resistance in gastrointestinal (GI) parasites of livestock and concerns about chemical residues in animal products and the environment are driving the development of alternative control strategies that are less reliant on the use of ...
Boas, Ulrik +7 more
core +4 more sources
Total synthesis of (+) artemisinin
Arkivoc, 2003 (+) Artemisinin is a sesquiterpene endoperoxide lactone with an unprecedented structure is a natural medicine for the treatment of malaria in particular drug against drug resistant malaria and cerebral malaria. The total synthesis of this novel sesquiterpene is described using an intermolecular radical reaction on important intermediate iodolactone ...
G. Sabitha +2 more
openaire +4 more sources