Results 131 to 140 of about 62,998 (285)
Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum
Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo +16 more
wiley +1 more source
Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance [PDF]
, 2018 Matthew J. Grigg +12 more
openalex +1 more source
A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum
Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo +16 more
wiley +1 more source
Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions
MedComm, Volume 6, Issue 12, December 2025.A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu +4 more
wiley +1 more source
Characterisation of Early Biosynthetic Steps of Atractylon via an Integrative Strategy
Plant Biotechnology Journal, Volume 23, Issue 12, Page 5728-5744, December 2025.ABSTRACT Atractylodes lancea, a vital medicinal plant, is renowned for its bioactive sesquiterpenoids, particularly atractylon. Despite its therapeutic importance, the genetic and biosynthetic pathways underlying atractylon production remain insufficiently understood.
Juan Zhu +12 more
wiley +1 more source
Screening for K13-Propeller Mutations Associated with Artemisinin Resistance in Plasmodium falciparum in Yambio County (Western Equatoria State, South Sudan) [PDF]
, 2023 Irene Molina‐de la Fuente +11 more
openalex +1 more source
Clinical Microbiology ReviewsSUMMARY The artemisinin antimalarials are the cornerstone of current malaria treatment. The development of artemisinin resistance in Plasmodium falciparum poses a major threat to malaria control and elimination.
N. J. White, K. Chotivanich
openaire +3 more sources
Plant Biotechnology Journal, Volume 23, Issue 12, Page 5817-5832, December 2025.ABSTRACT Salvia miltiorrhiza produces pharmacologically bioactive diterpenoid tanshinones which are regulated by jasmonate (JA) and abscisic acid (ABA) signalling, while their crosstalk in this process remains unclear. Here, we demonstrated that MeJA and ABA acted synergistically to enhance tanshinone biosynthesis.
Tingyao Liu +8 more
wiley +1 more source
The Plant Journal, Volume 124, Issue 5, December 2025.Significance Statement We find the unique evolutionary path of an autotetraploid Artemisia argyi involving gametic chromosome fusion preceding a species‐specific whole‐genome duplication and the functional divergence of an ADS tandem cluster that produces α‐bisabolol instead of the artemisinin precursor amorpha‐4,11‐diene, elucidating the genomic basis
Xinlian Chen +7 more
wiley +1 more source